NCT00804583Active, not recruiting
Genetic Modifiers of Cystic Fibrosis (CF) Liver Disease
Genetic Modifiers of CF Liver Disease
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
This study examines "modifier genes" that may play a role in the development of CF liver disease. Modifier genes are genes, other than the CF gene (CFTR), which may directly or indirectly have an affect on how the body responds to the conditions that develop as the result of the defective CFTR gene. Scientists have wondered why some patients with CF develop CF liver disease and why some patients with CF do not. To better understand the problem, this study was designed to examine the genetic makeup of CF patients who are considered to have severe liver disease to see if they can identify any modifier genes. Researchers will study blood samples, pulmonary function tests, and other medical information in hopes that a connection can be made between genetic make-up and how severe the liver disease is. The identification of modifier genes that influence disease severity may ultimately lead to a better understanding of CF liver disease, and may be useful in the development of new treatments.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 154 (actual)
- First submitted
- 8 Dec 2008
- Start date
- Mar 2004
- Primary completion date
- Jul 2028
- Lead sponsor
- University of North Carolina, Chapel Hill
- Diseases
- Cystic fibrosis
- NCT number
- NCT00804583
What you commit to
- Study type: Observational
- Participants enrolled: 154
- From Mar 2004 to the primary completion date, Jul 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of Alcohol Abuse
- History of Biliary Atresia
- History of Clinically Significant Hepatitis Infection
- History of Hepatic Vein Thrombosis
- History of Liver Cancer
- History of Portal Vein Thrombosis
- History of Clinically Significant use of total parenteral nutrition (TPN)
- History of Wilson's Disease
Who the study is looking for
- Volunteers with CF, regardless of genotype and age, who have "severe" liver disease with portal hypertension (big spleen, i.e. "splenomegaly" and/or presence of enlarged vessels in the esophagus, i.e. esophageal varices) may be eligible to participate. This would include any person who has been evaluated for a liver transplant, or has already received a liver transplant.
Age in the registry: 2 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University of North Carolina at Chapel Hill Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.