NCT00869817Recruiting
Dominantly Inherited Alzheimer Network (DIAN)
Source: ClinicalTrials.gov · Last updated 5 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 700 (estimated)
- First submitted
- 25 Mar 2009
- Start date
- 1 Jan 2009
- Primary completion date
- 30 Sept 2031
- Lead sponsor
- Washington University School of Medicine
- Diseases
- Alzheimer disease
- NCT number
- NCT00869817
What you commit to
- Study type: Observational
- Planned participants: 700
- From 1 Jan 2009 to the primary completion date, 30 Sept 2031
- 26 sites in 13 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Medical or psychiatric illness that would interfere in completing initial and follow-up visits
Age
- Under age 18
Other
- Requires nursing home level care
- Has no one who can serve as a study informant
Who the study is looking for
- Written informed consent obtained from participant and collateral source prior to any study-related procedures.
- Aged 18 (inclusive) or older and the child of an affected individual (clinically or by testing) in a pedigree with a known mutation for ADAD.
- Cognitively normal to very mild or mild cognitive impairment (CDR score range 0-1.0). Primary enrollment will focus on the recruitment of asymptomatic adult children who are more than 15 years younger than the estimated age of symptom onset. Enrollment of new participants with moderate cognitive impairment is allowed with the prior approval of the DIAN Coordinating Center.
- Has two persons who are not their full-blooded siblings who can serve as collateral sources for the study.
- Fluent in a language approved by the DIAN Coordinating Center at about the 6th grade level (international equivalent) or above.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (26)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia" (FLENI) Instituto de Investigaciones Neurológicas Raúl Correa Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Recruiting |
| Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Coordinator of this site? Confirm its status | Salta | Argentina | Recruiting |
| Mental Health Research Institute, University of Melbourne Coordinator of this site? Confirm its status | Melbourne | Australia | Suspended |
| Sir James McCusker Alzheimer's Disease Research Unit, Edith Cowan University Coordinator of this site? Confirm its status | Perth | Australia | Recruiting |
| Neuroscience Research Australia Coordinator of this site? Confirm its status | Sydney | Australia | Recruiting |
| Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo Coordinator of this site? Confirm its status | São Paulo | Brazil | Recruiting |
| McGill University Research Centre for Studies in Aging Coordinator of this site? Confirm its status | Verdun | Canada | Not yet recruiting |
| Grupo Neurociencias de Antioquia Coordinator of this site? Confirm its status | Medellín | Colombia | Recruiting |
| German Center for Neurodegenerative Diseases (DZNE) Munich, and University Hospital Ludwig-Maximilians-Universitat (LMU) Munich Coordinator of this site? Confirm its status | Munich | Germany | Recruiting |
| German Center for Neurodegenerative Diseases (DZNE) Tübingen and Hertie-Institute for Clinical Brain Research, University of Tübingen Coordinator of this site? Confirm its status | Tübingen | Germany | Recruiting |
| Hospital Clinic Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Suspended |
| Institute of Neurology, Queen Square Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Niigata University Coordinator of this site? Confirm its status | Niigata | Japan | Recruiting |
| Osaka City University Coordinator of this site? Confirm its status | Osaka | Japan | Suspended |
| Tokyo University Coordinator of this site? Confirm its status | Tokyo | Japan | Recruiting |
| Asan Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
| Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suarez" Coordinator of this site? Confirm its status | Mexico City | Mexico | Recruiting |
| Amsterdam UMC Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| Indiana University-Indiana Alzheimer Disease Center Coordinator of this site? Confirm its status | Indianapolis | United States | Recruiting |
| Mayo Clinic- Jacksonville Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
| Columbia University Coordinator of this site? Confirm its status | New York | United States | Suspended |
| University of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
| Butler Hospital Coordinator of this site? Confirm its status | Providence | United States | Recruiting |
| University of Washington Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Washington University in St. Louis, School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.