NCT00993460Active, not recruiting
Study of Changes in Skeletal Muscle After Caloric Restriction
Diacylglycerols and Insulin Action in Skeletal Muscle Upon Caloric Restriction
Source: ClinicalTrials.gov · Last updated 10 Jul 2026
Brief summary (registry, in English)
Research has shown that fat stored within muscles affects the muscle's sensitivity to insulin and ability to handle blood glucose. The purpose of this study is to examine the effects of weight loss surgery-induced caloric restriction on the accumulation and types of fats within skeletal muscle, as well as the effects of such caloric restriction on insulin sensitivity and inflammatory responses in skeletal muscle. The investigator proposes that caloric restriction will result in decreases in diacylglycerols enriched with saturated fat and increases in diacylglycerols enriched with monounsaturated fats.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 24 (estimated)
- First submitted
- 7 Oct 2009
- Start date
- Mar 2011
- Primary completion date
- Nov 2013
- Lead sponsor
- Vanderbilt University
- Diseases
- Obesity
- NCT number
- NCT00993460
What you commit to
- Study type: Observational
- Planned participants: 24
- From Mar 2011 to the primary completion date, Nov 2013
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Clinically significant heart disease
- Clinically significant hepatic or renal disease
Lab values
- Use of thiazide or furosemide diuretics, beta blockers, or other chronic medications with known adverse effects on glucose tolerance levels unless subject has been on stable dose of such medications for the past 3 months before entering the study
Other
- Pregnancy
- Breastfeeding
- Any abnormality that would preclude safe completion of study
- Use of statins
Who the study is looking for
- For Normal Weight Subjects:
- Age 21-65 years
- BMI of 21 to 27 kg/m2
- Normal glucose tolerance as determined by OGTT on day of screening
- No family history of diabetes
- For Morbidly Obese Subjects:
- Age 21-65 years
- BMI of 30 to 65 kg/m2
- Scheduled for Roux-en-Y gastric bypass at Vanderbilt Medical Center
- Insulin resistant as determined by OGTT on day of screening
Age in the registry: 21 years to 65 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.