NCT01051895Active, not recruiting
Colposcopy Versus HPV Testing to Identify Persistent Cervical Precancers
Randomized Controlled Trial Comparing Routine Colposcopy to HPV Testing to Identify Persistent or Recurrent High Grade Cervical Cancer Precursors
Source: ClinicalTrials.gov · Last updated 18 Mar 2026
Brief summary (registry, in English)
This trial will compare HPV testing to the routine colposcopy in the follow-up of women treated for cervical high grade lesions. Women will be assigned randomly (by chance) after treatment of cervical pre-cancer to be either (1) followed-up by colposcopy, or (2) undergo HPV testing. Women found to have disease by either strategy will be offered re-treatment. For the next 2 years participants will undergo yearly, in depth, evaluation to assess the cervix for precancer. We will then be able to compare which of the 2 follow-up strategies worked best.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 2253 (actual)
- First submitted
- 18 Jan 2010
- Start date
- Jan 2010
- Primary completion date
- Sept 2015
- Lead sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
- Diseases
- Cervical cancer
- NCT number
- NCT01051895
What you commit to
- Study type: Interventional
- Participants enrolled: 2253
- From Jan 2010 to the primary completion date, Sept 2015
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participant is receiving or has received one of the following treatment :
- Immunosuppressive therapy in the three months prior to enrollment
- Corticosteroid therapy in the two weeks prior to enrollment
- Two or more courses of corticosteroids (orally or parenterally) lasting at least one week in duration in the year prior to enrollment (inhalation, nasal or topical corticosteroids are permitted)
Other illness
- has been treated for cervical cancer or pre-cancer in the past
Other
- Participant has known immunosuppression or immunodeficiency
- Planned hysterectomy
- There is a strong probability that the participant will not follow the procedures of study, will not come to its appointment, or plans a delocalization throughout study.
Who the study is looking for
- Woman ≥ 18 years old 19 in British Columbia, Nova Scotia and Newfoundland)
- Understands English or French (for sites where French speaking coordinator is available)
- Is treated for biopsy proven CIN II, III or AIS
- Understands study procedures, available alternatives treatment, risks related to study, and accepts voluntarily to participate by signing the ICF.
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre de Recherche du CHUM Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.