NCT01104220Completed
Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to learn more about how the body stores fat in and around organs (for example in the liver) and why this affects some people's health more than others. Understanding this may lead to better treatments for diseases such as diabetes and cardiovascular disease.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 144 (estimated)
- First submitted
- 13 Apr 2010
- Start date
- Apr 2010
- Primary completion date
- 7 Dec 2025
- Lead sponsor
- Washington University School of Medicine
- Diseases
- Obesity, Fatty liver disease (MASLD/MASH)
- NCT number
- NCT01104220
What you commit to
- Study type: Interventional
- Planned participants: 144
- From Apr 2010 to the primary completion date, 7 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- active or previous history of liver diseases other than NAFLD
- cancer diagnosis within the previous 5 years
- medications that might confound the study results
Other illness
- history of alcohol abuse
Lab values
- severe hypertriglyceridemia (\>300 mg/dL)
Other
- currently consuming ≥20 g alcohol/day
- smoke tobacco
- pregnancy or lactation
- exercise \>2 h/week
Who the study is looking for
- Lean, metabolically healthy group - Body mass index (BMI) 18.5-24.9 kg/m2, HbA1C ≤5.6%, fasting plasma glucose concentration \<100 mg/dl, 2-h OGTT plasma glucose concentration \<140 mg/dl and intrahepatic triglyceride (IHTG) content ≤5%.
- Obese, metabolically healthy group - BMI ≥30 kg/m2, HHbA1C ≤5.6%, fasting plasma glucose concentration \<100 mg/dl, 2-h OGTT plasma glucose concentration \<140 mg/dl and intrahepatic triglyceride (IHTG) content ≤5%.
- Obese, metabolically healthy group - BMI ≥30 kg/m2, IHTG content ≥5.6% and HbA1C ≥5.7% or fasting plasma glucose concentration ≥100 mg/dl or 2-h OGTT plasma glucose concentration ≥140 mg/dl.
- Lean, scheduled for inguinal hernia, hysterectomy or myomectomy surgery - BMI 18.5-24.9 kg/m2, HbA1C ≤5.6%, fasting plasma glucose concentration \<100 mg/dl, 2-h OGTT plasma glucose concentration \<140 mg/dl and IHTG content ≤5%.
- Obese, scheduled for bariatric and gallbladder surgery - BMI ≥35.0kg/m2
Age in the registry: 18 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Washington University School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.