NCT01251861CompletedPhase 2
Bicalutamide With or Without Akt Inhibitor MK2206 in Treating Patients With Previously Treated Prostate Cancer
Androgen Receptor Modulation Phase II, Randomized Study of MK-2206 - Bicalutamide Combination in Patients With Rising PSA at High-Risk of Progression After Primary Therapy
Source: ClinicalTrials.gov · Last updated 25 Jun 2026
Brief summary (registry, in English)
This phase II trial studies how well giving bicalutamide with or without Akt inhibitor MK2206 works in treating patients with previously treated prostate cancer. Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as bicalutamide, may lessen the amount of androgens made by the body. Akt inhibitor MK2206 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether bicalutamide is more effective with or without Akt inhibitor MK2206 in treating prostate cancer.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 108 (actual)
- First submitted
- 1 Dec 2010
- Start date
- 17 Mar 2011
- Primary completion date
- 17 Jul 2018
- Lead sponsor
- National Cancer Institute (NCI)
- Diseases
- Prostate cancer
- NCT number
- NCT01251861
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 108
- From 17 Mar 2011 to the primary completion date, 17 Jul 2018
- 198 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Patient must have histologically confirmed diagnosis of prostate cancer
- Patient must have had previous treatment with definitive surgery or radiation therapy or cryoablation
- Patient may have prior salvage therapy (surgery, radiation or other local ablative procedures) within 4 weeks prior to randomization if the intent was for cure; prophylactic radiotherapy to prevent gynecomastia within 4 weeks prior to randomization is allowed
- Patient must have no evidence of metastatic disease on physical exam, computed tomography (CT) abdomen/pelvis (or magnetic resonance imaging \[MRI\]), chest x-ray (or CT chest) and bone scan within 8 weeks prior to randomization
- Patient may have had prior neoadjuvant and/or adjuvant therapy (chemotherapy, vaccines or experimental agents) within 4 weeks prior to randomization, if the PSA rise and PSA doubling time (PSADT) were documented after the testosterone level was \> 150 ng/dL
- Patient may not have had therapy modulating testosterone levels (such as luteinizing-hormone, releasing-hormone agonists/antagonists and antiandrogens) within 1 year prior to randomization, unless it was in the neoadjuvant and/or adjuvant setting; agents such as 5 alpha reductase inhibitors, ketoconazole, abiraterone, systemic steroids, or herbal supplements known to decrease PSA levels including any dose of megestrol acetate, finasteride (e.g., Saw Palmetto and PC-SPES, African pygeum extract, lycopene, alanine, glutamic acid and glycine, beta-sitosterol, lycopene, nettle root extract, quercitin, Belizian Man Vine extract, mulra puama extract and epimedium extract campesterol, beta-sitosterol, stigmasterol, sitostanol and brassicasterol) are not permitted at any time during the period that the PSA values are being collected
- Patient must have hormone-sensitive prostate cancer as evident by a serum total testosterone level \> 150 ng/dL within 12 weeks prior to randomization
- Patient must have evidence of biochemical failure after primary therapy and subsequent progression
- Biochemical failure is declared when the PSA reaches a threshold value after primary treatment and it differs for radical prostatectomy or radiation therapy
- For radical prostatectomy the threshold for this study is PSA \>= 0.4 ng/mL
- For radiation therapy the threshold is a PSA rise of 2 ng/mL above the nadir PSA achieved post radiation with or without hormone therapy (2006 Radiation Therapy Oncology Group \[RTOG\]-American Society for Radiation Oncology \[ASTRO\] Consensus definition)
- PSA progression requires a PSA rise above the threshold (PSA1) measured at any time point since the threshold was reached
- The PSADT must be \< 12 months; requires two consecutive PSA rises (PSA2 and PSA3) above the PSA1; PSA2 and PSA3 must be obtained within 6 months of study entry; all baseline PSAs should be obtained, preferably, at the same reference lab
- PSADT calculation needs 3 PSA values:
- PSA1 is any PSA value that is equal or greater than the threshold PSA (0.4 ng/mL for radical prostatectomy or 2 ng/mL above the nadir for primary radiation therapy) indicating biochemical relapse
- PSA2 must be higher than PSA1, obtained at least 2 weeks after PSA1 and within 6 months or less from randomization
- PSA3 must be higher than PSA2 and obtained at least 2 weeks after PSA2
- Baseline PSA must have reached a minimum of 2 ng/mL but be no greater than 50 ng/mL and equal or higher than PSA3; PSA3 may be used as baseline PSA if obtained within 1 week of randomization
- Patient's PSA doubling time (PSADT) must be less than 12 months
- Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Granulocytes \>= 1,500/mm\^3
- Platelet count \>= 100,000/mm\^3
- Serum creatinine within normal institutional limits or creatinine clearance \>= 50 ml/min for patients with creatinine levels above institutional normal
- Serum total bilirubin =\< 1.5 times upper limit of normal (ULN)
- Alkaline phosphatase (ALP) =\< 2.5 x ULN
- Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase \[AST\]) and serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase \[ALT\]) \< 2.5 x institutional upper limit of normal
- Human immunodeficiency virus (HIV)-positive patients are excluded from this study
- Patient cannot receive concurrent therapeutic administration of anticoagulant therapy; low dosage aspirin =\< 325 mg per day is allowed
- Patients with impaired cardiac function including any one of the following will be excluded from entry on study:
- Baseline corrected QT interval (QTc) \> 450 msec (male) (patients with QTc 450-480 msec will be allowed to participate in this trial if they do not have any of the other cardiac conditions mentioned in this section)
- Patients with congenital long QT syndrome
- History of sustained ventricular tachycardia
- Any history of ventricular fibrillation or torsades de pointes
- Concomitant use of drugs with a risk of causing torsades de pointes
- Bradycardia defined as heart rate \< 50 beats per minute; patients with a pacemaker and heart rate \>= 50 beats per minute are eligible
- Myocardial infarction or unstable angina within 6 months of study entry
- Congestive heart failure (New York Heart Association class III or IV)
- Right bundle branch block and left anterior hemi-block (bifascicular block)
- Patient must not have gastrointestinal (GI) tract disease resulting in an inability to take oral medication, malabsorption syndrome, a requirement for intravenous (IV) alimentation, prior surgical procedures affecting absorption, uncontrolled inflammatory GI disease (e.g., Crohn's, ulcerative colitis)
- Patient may not be receiving any other investigational agents or receiving concurrent anticancer therapy (chemotherapy, immunotherapy, radiation therapy, surgery for cancer, or experimental medications) at time of randomization
- Patient may not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-2206 or bicalutamide
- Patient must not have any uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Patients with diabetes or at risk for hyperglycemia MUST not be excluded from trials with MK-2206, but the hyperglycemia should be well controlled before the patient enters the trial
- Patients receiving any medications or substances that are inhibitors or inducers of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) are ineligible
- Patient must NOT have previous or concurrent malignancy; exceptions are made for patients who meet any of the following conditions:
- Basal cell or squamous cell carcinoma of the skin OR
- Prior malignancy has been adequately treated and patient has been continuously disease free for \>= 2 years
- Patient must agree to use barrier contraception during and for 3 months after discontinuation of study treatment; if patient impregnates a woman while on treatment or within 3 months of discontinuing treatment, he should inform his treating physician immediately
- Patients must discontinue use of enzyme-inducing anti-epileptic drugs (EIAEDs) \>= 14 days prior to study enrollment; the investigator may prescribe non-EIAEDs; patients who must begin EIAED therapy while on study will be allowed to remain
- Patients must not be taking cytochrome P450 enzyme-inducing antiepileptic drugs (phenytoin, carbamazepine or phenobarbital), St John's Wort, ketoconazole, dexamethasone, the dysrhythmic drugs (terfenadine, quinidine, procainamide, sotalol, probucol, bepridil, indapamide or flecainide), haloperidol, risperidone, rifampin, grapefruit, or grapefruit juice within two weeks of randomization and during the course of therapy
- Patients may have received targeted agents (angiogenesis inhibitors, epidermal growth factor receptor \[EGFR\] inhibitors, mammalian target of rapamycin \[mTOR\] inhibitors, phosphatidylinositol 3 kinase \[PI3K\] inhibitors, etc.), however patients must have discontinued treatment with the targeted agent(s) at least 4 weeks prior to enrollment; if the patient stopped targeted agent(s) due to unresolved or persistent grade 3 or 4 toxicity, patient cannot be enrolled onto the study regardless of the length of time since discontinuation of treatment with targeted agent(s)
Age in the registry: 18 years to - · Sex: Male · Does not accept healthy volunteers
Sites (198)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cork University Hospital Coordinator of this site? Confirm its status | Cork | Ireland | Unknown status |
| Tallaght University Hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Unknown status |
| Mater Misericordiae University Hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Unknown status |
| Mater Private Hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Unknown status |
| Saint Vincent's University Hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Unknown status |
| University College Hospital Galway Coordinator of this site? Confirm its status | Galway | Ireland | Unknown status |
| Hickman Cancer Center Coordinator of this site? Confirm its status | Adrian | United States | Unknown status |
| Bixby Medical Center Coordinator of this site? Confirm its status | Adrian | United States | Unknown status |
| University of New Mexico Cancer Center Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| Hematology Oncology Associates Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| McFarland Clinic - Ames Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| Michigan Cancer Research Consortium NCORP Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Emory University Hospital/Winship Cancer Institute Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| The Medical Center of Aurora Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Rush-Copley Medical Center Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Johns Hopkins University/Sidney Kimmel Cancer Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| OSF Saint Joseph Medical Center Coordinator of this site? Confirm its status | Bloomington | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Boise Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| Tufts Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Boulder Community Foothills Hospital Coordinator of this site? Confirm its status | Boulder | United States | Unknown status |
| Toledo Clinic Cancer Centers-Bowling Green Coordinator of this site? Confirm its status | Bowling Green | United States | Unknown status |
| Essentia Health Saint Joseph's Medical Center Coordinator of this site? Confirm its status | Brainerd | United States | Unknown status |
| Fairview Ridges Hospital Coordinator of this site? Confirm its status | Burnsville | United States | Unknown status |
| Butler Memorial Hospital Coordinator of this site? Confirm its status | Butler | United States | Unknown status |
| Cooper Hospital University Medical Center Coordinator of this site? Confirm its status | Camden | United States | Unknown status |
| Graham Hospital Association Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Saint Francis Medical Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Memorial Hospital Coordinator of this site? Confirm its status | Carthage | United States | Unknown status |
| John H Stroger Jr Hospital of Cook County Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| MetroHealth Medical Center Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Coordinator of this site? Confirm its status | Clive | United States | Unknown status |
| North Coast Cancer Care-Clyde Coordinator of this site? Confirm its status | Clyde | United States | Unknown status |
| Penrose-Saint Francis Healthcare Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Mercy Hospital Coordinator of this site? Confirm its status | Coon Rapids | United States | Unknown status |
| UT Southwestern/Simmons Cancer Center-Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Parkland Memorial Hospital Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Geisinger Medical Center Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| Corewell Health Dearborn Hospital Coordinator of this site? Confirm its status | Dearborn | United States | Unknown status |
| Heartland Cancer Research NCORP Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Atlanta VA Medical Center Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Decatur Memorial Hospital Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Saint Joseph Hospital - Cancer Centers of Colorado Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Western States Cancer Research NCORP Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Rose Medical Center Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Presbyterian - Saint Lukes Medical Center - Health One Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| AdventHealth Porter Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Iowa-Wide Oncology Research Coalition NCORP Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Iowa Methodist Medical Center Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Mercy Medical Center - Des Moines Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Iowa Lutheran Hospital Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Henry Ford Health Saint John Hospital Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| Essentia Health Saint Mary's Medical Center Coordinator of this site? Confirm its status | Duluth | United States | Unknown status |
| Essentia Health Cancer Center Coordinator of this site? Confirm its status | Duluth | United States | Unknown status |
| Miller-Dwan Hospital Coordinator of this site? Confirm its status | Duluth | United States | Unknown status |
| University of Maryland Shore Medical Center at Easton Coordinator of this site? Confirm its status | Easton | United States | Unknown status |
| Veterans Adminstration New Jersey Health Care System Coordinator of this site? Confirm its status | East Orange | United States | Unknown status |
| Fairview Southdale Hospital Coordinator of this site? Confirm its status | Edina | United States | Unknown status |
| Elkhart General Hospital Coordinator of this site? Confirm its status | Elkhart | United States | Unknown status |
| Christiana Care - Union Hospital Coordinator of this site? Confirm its status | Elkton | United States | Unknown status |
| Mercy Cancer Center-Elyria Coordinator of this site? Confirm its status | Elyria | United States | Unknown status |
| Hematology Oncology Center Incorporated Coordinator of this site? Confirm its status | Elyria | United States | Unknown status |
| Swedish Medical Center Coordinator of this site? Confirm its status | Englewood | United States | Unknown status |
| Eureka Hospital Coordinator of this site? Confirm its status | Eureka | United States | Unknown status |
| NorthShore University HealthSystem-Evanston Hospital Coordinator of this site? Confirm its status | Evanston | United States | Unknown status |
| Lake Region Healthcare Corporation-Cancer Care Coordinator of this site? Confirm its status | Fergus Falls | United States | Unknown status |
| Genesys Regional Medical Center-West Flint Campus Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Genesys Hurley Cancer Institute Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Hurley Medical Center Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Poudre Valley Hospital Coordinator of this site? Confirm its status | Fort Collins | United States | Unknown status |
| Fredericksburg Oncology Inc Coordinator of this site? Confirm its status | Fredericksburg | United States | Unknown status |
| Unity Hospital Coordinator of this site? Confirm its status | Fridley | United States | Unknown status |
| Illinois CancerCare-Galesburg Coordinator of this site? Confirm its status | Galesburg | United States | Unknown status |
| Saint Mary's Hospital and Regional Medical Center Coordinator of this site? Confirm its status | Grand Junction | United States | Unknown status |
| Banner North Colorado Medical Center Coordinator of this site? Confirm its status | Greeley | United States | Unknown status |
| Saint Vincent Hospital Cancer Center Green Bay Coordinator of this site? Confirm its status | Green Bay | United States | Unknown status |
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus Coordinator of this site? Confirm its status | Harrisburg | United States | Unknown status |
| Smilow Cancer Hospital Care Center at Saint Francis Coordinator of this site? Confirm its status | Hartford | United States | Unknown status |
| Mason District Hospital Coordinator of this site? Confirm its status | Havana | United States | Unknown status |
| Geisinger Medical Center-Cancer Center Hazleton Coordinator of this site? Confirm its status | Hazleton | United States | Unknown status |
| Hinsdale Hematology Oncology Associates Incorporated Coordinator of this site? Confirm its status | Hinsdale | United States | Unknown status |
| Hutchinson Area Health Care Coordinator of this site? Confirm its status | Hutchinson | United States | Unknown status |
| Indiana University/Melvin and Bren Simon Cancer Center Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| IU Health Methodist Hospital Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Sidney and Lois Eskenazi Hospital Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Richard L. Roudebush Veterans Affairs Medical Center Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| IU Health Central Indiana Cancer Centers-East Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Allegiance Health Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| Mayo Clinic in Florida Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Bronson Methodist Hospital Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| West Michigan Cancer Center Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| Beacon Kalamazoo Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| Community Howard Regional Health Coordinator of this site? Confirm its status | Kokomo | United States | Unknown status |
| Horizon Oncology Research LLC Coordinator of this site? Confirm its status | Lafayette | United States | Unknown status |
| CommonSpirit Saint Anthony Hospital Cancer Center Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| Saint Mary Medical and Regional Cancer Center Coordinator of this site? Confirm its status | Langhorne | United States | Unknown status |
| University of Michigan Health - Sparrow Lansing Coordinator of this site? Confirm its status | Lansing | United States | Unknown status |
| IU Health La Porte Hospital Coordinator of this site? Confirm its status | La Porte | United States | Unknown status |
| Memorial Medical Center-Las Cruces Coordinator of this site? Confirm its status | Las Cruces | United States | Unknown status |
| Nevada Cancer Research Foundation NCORP Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Beebe Medical Center Coordinator of this site? Confirm its status | Lewes | United States | Unknown status |
| Lima Memorial Hospital Coordinator of this site? Confirm its status | Lima | United States | Unknown status |
| AdventHealth Littleton Coordinator of this site? Confirm its status | Littleton | United States | Unknown status |
| Trinity Health Saint Mary Mercy Livonia Hospital Coordinator of this site? Confirm its status | Livonia | United States | Unknown status |
| Sky Ridge Medical Center Coordinator of this site? Confirm its status | Lone Tree | United States | Unknown status |
| Longmont United Hospital Coordinator of this site? Confirm its status | Longmont | United States | Unknown status |
| Banner North Colorado Medical Center - Loveland Campus Coordinator of this site? Confirm its status | Loveland | United States | Unknown status |
| Mcdonough District Hospital Coordinator of this site? Confirm its status | Macomb | United States | Unknown status |
| Holy Family Memorial Hospital Coordinator of this site? Confirm its status | Manitowoc | United States | Unknown status |
| Minnesota Oncology Hematology PA-Maplewood Coordinator of this site? Confirm its status | Maplewood | United States | Unknown status |
| Saint John's Hospital - Healtheast Coordinator of this site? Confirm its status | Maplewood | United States | Unknown status |
| Bay Area Medical Center Coordinator of this site? Confirm its status | Marinette | United States | Unknown status |
| Toledo Clinic Cancer Centers-Maumee Coordinator of this site? Confirm its status | Maumee | United States | Unknown status |
| Saint Luke's Hospital Coordinator of this site? Confirm its status | Maumee | United States | Unknown status |
| Franciscan Saint Anthony Health-Michigan City Coordinator of this site? Confirm its status | Michigan City | United States | Unknown status |
| Hennepin County Medical Center Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Abbott-Northwestern Hospital Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Saint Joseph Regional Medical Center-Mishawaka Coordinator of this site? Confirm its status | Mishawaka | United States | Unknown status |
| Trinity Medical Center Coordinator of this site? Confirm its status | Moline | United States | Unknown status |
| Mercy Memorial Hospital Coordinator of this site? Confirm its status | Monroe | United States | Unknown status |
| Toledo Clinic Cancer Centers-Monroe Coordinator of this site? Confirm its status | Monroe | United States | Unknown status |
| Christiana Care Health System-Christiana Hospital Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Rutgers Cancer Institute of New Jersey Coordinator of this site? Confirm its status | New Brunswick | United States | Unknown status |
| Cancer Center of Western Wisconsin Coordinator of this site? Confirm its status | New Richmond | United States | Unknown status |
| New Ulm Medical Center Coordinator of this site? Confirm its status | New Ulm | United States | Unknown status |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Mount Sinai Union Square Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Carle Cancer Institute Normal Coordinator of this site? Confirm its status | Normal | United States | Unknown status |
| Carle BroMenn Medical Center Coordinator of this site? Confirm its status | Normal | United States | Unknown status |
| Fisher-Titus Medical Center Coordinator of this site? Confirm its status | Norwalk | United States | Unknown status |
| ProHealth Oconomowoc Memorial Hospital Coordinator of this site? Confirm its status | Oconomowoc | United States | Unknown status |
| Toledo Clinic Cancer Centers-Oregon Coordinator of this site? Confirm its status | Oregon | United States | Unknown status |
| Saint Charles Hospital Coordinator of this site? Confirm its status | Oregon | United States | Unknown status |
| Ottawa Regional Hospital and Healthcare Center Coordinator of this site? Confirm its status | Ottawa | United States | Unknown status |
| Stanford Cancer Institute Palo Alto Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| VA Palo Alto Health Care System Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| AdventHealth Parker Coordinator of this site? Confirm its status | Parker | United States | Unknown status |
| OSF Saint Francis Radiation Oncology at Pekin Coordinator of this site? Confirm its status | Pekin | United States | Unknown status |
| Methodist Medical Center of Illinois Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| OSF Saint Francis Medical Center Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Illinois CancerCare-Peoria Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Proctor Hospital Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Illinois Valley Hospital Coordinator of this site? Confirm its status | Peru | United States | Unknown status |
| University of Pennsylvania/Abramson Cancer Center Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Fox Chase Cancer Center Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Thomas Jefferson University Hospital Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| University of Pittsburgh Cancer Institute (UPCI) Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Trinity Health Saint Joseph Mercy Oakland Hospital Coordinator of this site? Confirm its status | Pontiac | United States | Unknown status |
| Lake Huron Medical Center Coordinator of this site? Confirm its status | Port Huron | United States | Unknown status |
| Perry Memorial Hospital Coordinator of this site? Confirm its status | Princeton | United States | Unknown status |
| Saint Mary Corwin Medical Center Coordinator of this site? Confirm its status | Pueblo | United States | Unknown status |
| North Memorial Medical Health Center Coordinator of this site? Confirm its status | Robbinsdale | United States | Unknown status |
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Swedish American Hospital Coordinator of this site? Confirm its status | Rockford | United States | Unknown status |
| MyMichigan Medical Center Saginaw Coordinator of this site? Confirm its status | Saginaw | United States | Unknown status |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Coordinator of this site? Confirm its status | Saint Joseph | United States | Unknown status |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital Coordinator of this site? Confirm its status | Saint Joseph | United States | Unknown status |
| Park Nicollet Clinic - Saint Louis Park Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| Metro-Minnesota Community Oncology Research Consortium Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| Regions Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| United Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| North Coast Cancer Care Coordinator of this site? Confirm its status | Sandusky | United States | Unknown status |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Coordinator of this site? Confirm its status | Savannah | United States | Unknown status |
| Saint Francis Regional Medical Center Coordinator of this site? Confirm its status | Shakopee | United States | Unknown status |
| HSHS Saint Nicholas Hospital Coordinator of this site? Confirm its status | Sheboygan | United States | Unknown status |
| Saint Luke's Regional Medical Center Coordinator of this site? Confirm its status | Sioux City | United States | Unknown status |
| Siouxland Regional Cancer Center Coordinator of this site? Confirm its status | Sioux City | United States | Unknown status |
| Mercy Medical Center-Sioux City Coordinator of this site? Confirm its status | Sioux City | United States | Unknown status |
| Memorial Hospital of South Bend Coordinator of this site? Confirm its status | South Bend | United States | Unknown status |
| South Bend Clinic Coordinator of this site? Confirm its status | South Bend | United States | Unknown status |
| Northern Indiana Cancer Research Consortium Coordinator of this site? Confirm its status | South Bend | United States | Unknown status |
| Baystate Medical Center Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Memorial Hospital Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Geisinger Medical Group Coordinator of this site? Confirm its status | State College | United States | Unknown status |
| Trinity's Tony Teramana Cancer Center Coordinator of this site? Confirm its status | Steubenville | United States | Unknown status |
| Lakeview Hospital Coordinator of this site? Confirm its status | Stillwater | United States | Unknown status |
| ProMedica Flower Hospital Coordinator of this site? Confirm its status | Sylvania | United States | Unknown status |
| North Suburban Medical Center Coordinator of this site? Confirm its status | Thornton | United States | Unknown status |
| Mercy Hospital of Tiffin Coordinator of this site? Confirm its status | Tiffin | United States | Unknown status |
| Mercy Health - Saint Anne Hospital Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| Toledo Clinic Cancer Centers-Toledo Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| University of Toledo Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| Mercy Health - Saint Vincent Hospital Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| Toledo Community Hospital Oncology Program CCOP Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| Carle Cancer Center Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| Ridgeview Medical Center Coordinator of this site? Confirm its status | Waconia | United States | Unknown status |
| Henry Ford Health Warren Hospital Coordinator of this site? Confirm its status | Warren | United States | Unknown status |
| Sibley Memorial Hospital Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| ProHealth Waukesha Memorial Hospital Coordinator of this site? Confirm its status | Waukesha | United States | Unknown status |
| Fulton County Health Center Coordinator of this site? Confirm its status | Wauseon | United States | Unknown status |
| Intermountain Health Lutheran Hospital Coordinator of this site? Confirm its status | Wheat Ridge | United States | Unknown status |
| Geisinger Wyoming Valley/Henry Cancer Center Coordinator of this site? Confirm its status | Wilkes-Barre | United States | Unknown status |
| Rice Memorial Hospital Coordinator of this site? Confirm its status | Willmar | United States | Unknown status |
| Aspirus Cancer Care - Wisconsin Rapids Coordinator of this site? Confirm its status | Wisconsin Rapids | United States | Unknown status |
| Minnesota Oncology Hematology PA-Woodbury Coordinator of this site? Confirm its status | Woodbury | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.