NCT01334749Active, not recruiting
Observational Study on Determinants of Dementia After Stroke
Determinants of Dementia After Stroke
Source: ClinicalTrials.gov · Last updated 20 Mar 2024
Brief summary (registry, in English)
The primary aim of the DEDEMAS (Determinants of Dementia After Stroke) study is to identify predictors of post stroke dementia (PSD). A particular focus will be on biological markers (neuroimaging, biochemical markers derived from blood) and on interactions between vascular and neurodegenerative mechanisms. For this purpose patients with an acute stroke and without prior dementia will be followed for 10 years. Note: Starting from 01.01.2014 this study is expanded to a multi-centric design funded by the German Center for Neurodegenerative Diseases (The DZNE - Mechanisms of Dementia After Stroke (DEMDAS) Study). This includes the following study sites: DZNE/München - Institute for Stroke and Dementia Research, Klinikum der Universität München (Coordinator); DZNE/Berlin - Neuroscience Research Center - Campus Mitte Charité; DZNE/Bonn - Klinik und Poliklinik für Neurologie, Universitätsklinikum Bonn; DZNE/Göttingen - University Medical Center Göttingen; DZNE/Magdeburg - Universitätsklinikum Magdeburg.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 736 (actual)
- First submitted
- 12 Apr 2011
- Start date
- Apr 2011
- Primary completion date
- Jan 2029
- Lead sponsor
- Ludwig-Maximilians - University of Munich
- Diseases
- Stroke, Alzheimer disease
- NCT number
- NCT01334749
What you commit to
- Study type: Observational
- Participants enrolled: 736
- From Apr 2011 to the primary completion date, Jan 2029
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- IQCODE \> 64 or diagnosis of dementia
- Patients transferred from an outside stroke unit (to avoid possible selection bias)
- Patients presenting a stroke going back more than 120 hours
- Patients presenting one of the following diseases: cerebral venous thrombosis, traumatic cerebral haemorrhage, intracerebral haemorrhage because of a known or image-guided assumed vascular malformation, pure meningeal or intraventricular haemorrhage
Age
- Patients presenting a malignant disease with life expectancy \< 3years
Other
- Contraindication for MRI
- Participation in an intervention/AMG-study at baseline
Who the study is looking for
- Age ≥ 18 years
- Language: German
- Acute stroke that occurred within the last 5 days as defined by:
- acute focal neurological deficit in combination with one of the following:
- An acute ischemic infarct as documented by either a DWI positive lesion on MR imaging or a new lesion on a delayed CT scan
- An intracerebral hemorrhage as documented on CT or MRI
- An informant of the patient is available
- Written informed consent by patient prior to study participation
- Willingness to participate in follow-up
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| DZNE/Berlin - Neuroscience Research Center - Campus Mitte Charité Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| DZNE/Bonn - Klinik und Poliklinik für Neurologie, Universitätsklinikum Bonn Coordinator of this site? Confirm its status | Bonn | Germany | Unknown status |
| DZNE/Göttingen - University Medical Center Göttingen Coordinator of this site? Confirm its status | Göttingen | Germany | Unknown status |
| DZNE/Magdeburg - Universitätsklinikum Magdeburg Coordinator of this site? Confirm its status | Magdeburg | Germany | Unknown status |
| DZNE/Munich-Interdisciplinary Stroke Center Munich, Klinikum der Universität München, Campus Großhadern Coordinator of this site? Confirm its status | Munich | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.