NCT01353547Recruiting
Genes and Environment in Multiple Sclerosis
Integrating Genetic and Environmental Risk Scores Into an Algorithm to Predict Multiple Sclerosis Susceptibility
Source: ClinicalTrials.gov · Last updated 14 May 2026
Brief summary (registry, in English)
The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 5000 (estimated)
- First submitted
- 11 May 2011
- Start date
- 1 Oct 2017
- Primary completion date
- Oct 2040
- Lead sponsor
- Columbia University
- Diseases
- Multiple sclerosis
- NCT number
- NCT01353547
What you commit to
- Study type: Observational
- Planned participants: 5000
- From 1 Oct 2017 to the primary completion date, Oct 2040
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Does not match any of the inclusion criteria
Who the study is looking for
- First Degree Relatives of Patients with MS, or
- Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or
- Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS
- Live in the United States
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Institute of Neurological Disorders and Stroke Coordinator of this site? Confirm its status | Bethesda | United States | Recruiting |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Terminated |
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Terminated |
| Columbia University Irving Center Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| University of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
Related publications
- A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies.Ann Clin Transl Neurol · 2026 · PMID 41700751
This page is information, not medical advice. Discuss any trial with your doctor.