NCT01449149Completed
Proton Radiation for Chordomas and Chondrosarcomas
Source: ClinicalTrials.gov · Last updated 5 Dec 2025
Brief summary (registry, in English)
The objectives of this study are 1) To evaluate the feasibility and acute side effects of proton therapy for chordomas and chondrosarcomas and 2) To evaluate clinical outcomes and long term side effects of proton beam radiation for treatment of chordomas and chondrosarcomas.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 54 (actual)
- First submitted
- 4 Oct 2011
- Start date
- 1 Mar 2010
- Primary completion date
- 31 Jul 2025
- Lead sponsor
- Abramson Cancer Center at Penn Medicine
- Diseases
- Sarcoma
- NCT number
- NCT01449149
What you commit to
- Study type: Interventional
- Participants enrolled: 54
- From 1 Mar 2010 to the primary completion date, 31 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior or simultaneous malignancies within the past two years (other than cutaneous squamous or basal cell carcinoma, melanoma in situ or thyroid carcinoma)
Other
- Patients with the following histologies are excluded: melanoma , other soft tissue or bony sarcomas, giant cell tumor aneurismal bone cyst or metastatic lesions from other histologies.
- Pregnant women.
- Actively being treated on any other therapeutic research study.
- Tumors arising outside of the CNS.
Who the study is looking for
- Histologically confirmed diagnosis of chordoma or chondrosarcoma.
- Patients must have no evidence of metastatic disease based on routine imaging (CT or MRI of the chest/abdomen/pelvis, bone scan, etc.)
- Patients must have an ECOG score equal to or less than 2.
- Age ≥ 18 years.
- Patients must be able to provide informed consent.
- Adequate bone marrow function: WBC ≥ 4000/mm3, platelets ≥ 100, 000mm3
- Women of child-bearing potential as long as she agrees to use a recognized method of birth control (e.g. oral contraceptive , IUD, condoms or other barrier methods etc.) Hysterectomy or menopause must be clinically documented.
- Tumors arising in the skull and spine.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Abramson Cancer Center of the University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.