NCT01533636Completed
CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment
CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment to Lung Mucin
Source: ClinicalTrials.gov · Last updated 10 Feb 2026
Brief summary (registry, in English)
The investigators will collect samples of sputum from healthy volunteers and patients with cystic fibrosis for the purpose of: a) purifying airway mucins for plate-based binding studies and; b) assessment of the effects of carbohydrates on the rheologic properties of the sputum. This study has two hypotheses: 1. Lectins from Pseudomonas aeruginosa and Aspergillus fumigatus bind to airway mucins in a fucose-dependent manner, and this binding can be inhibited by fucosyl glycomimetic compounds. 2. Fucosyl glycomimetics will compete with Pseudomonas aeruginosa lectin (PA-IIL) and Aspergillus fumigatus lectin (AFL) and disrupt lectin-driven mucin cross-linking in CF sputum.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 114 (actual)
- First submitted
- 10 Feb 2012
- Start date
- 17 Jul 2012
- Primary completion date
- 1 Mar 2020
- Lead sponsor
- University of California, San Francisco
- Diseases
- Cystic fibrosis
- NCT number
- NCT01533636
What you commit to
- Study type: Observational
- Participants enrolled: 114
- From 17 Jul 2012 to the primary completion date, 1 Mar 2020
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of recreational drugs within 30 days prior to enrollment
- Use of tobacco within 30 days prior to enrollment, or \> 10 pack-year tobacco history
Other
- Pregnant or lactating females
Who the study is looking for
- Healthy control subjects:
- Age 18-65
- No history of lung disease
- Cystic fibrosis subjects:
- Age 18-65
- No history of lung disease other than cystic fibrosis
- Diagnosis of CF if sweat chloride values \> 60 mM on two separate pilocarpine iontophoresis sweat tests and/or two allelic CF-producing mutations in genetic analysis
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of California San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.