NCT01545999Active, not recruiting
Paired Associative Stimulation in the Dorsolateral Prefrontal Cortex in Patients With Schizophrenia
Paired Associative Stimulation in the Dorsolateral Prefrontal Cortex in Patients With Schizophrenia: a Combined Transcranial Magnetic Stimulation and Electroencephalography Study Across the Life Span
Source: ClinicalTrials.gov · Last updated 9 Apr 2026
Brief summary (registry, in English)
The purpose of this study is to 1. assess the effect of PAS in schizophrenia in the dorsolateral prefrontal cortex (DLPFC) 2. assess the effect of PAS induced long-term potentiation (LTP) on the performance of patients with schizophrenia on a cognitive task related to DLFPC.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 72 (estimated)
- First submitted
- 17 Jan 2012
- Start date
- Mar 2012
- Primary completion date
- Dec 2026
- Lead sponsor
- Centre for Addiction and Mental Health
- Diseases
- Schizophrenia
- NCT number
- NCT01545999
What you commit to
- Study type: Interventional
- Planned participants: 72
- From Mar 2012 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Meets diagnostic criteria for current alcohol or other drug dependence within 6 months of testing
- Electroconvulsive Therapy (ECT) within 6 months of testing.
- Psychotropic medication except for sedative /hypnotics at a stable dose for at least 4 weeks.
Other illness
- Meets criteria for a cognitive disorder secondary to a neurological or other medical disorder affecting the central nervous system (for example, multiple sclerosis, history of traumatic brain injury, stroke, untreated hypothyroidism).
- Diagnosis of bipolar disorder or current major depressive episode.
- DSM IV TR psychiatric diagnosis except for simple phobias or an adjustment disorder.
- Other neurological disorder affecting central nervous system.
- Family history of a primary psychotic disorder in a first-degree relative.
Other
- Mini Mental Status Examination score of 17 and less because a subject with a very low MMSE score is unlikely to be able to compete the NP battery.
- Left handedness.
- Incompetency to consent
- Left handedness.
Who the study is looking for
- Age 18 or above
- All races and ethnicities.
- Females and males.
- Meet DSM-IV TR criteria for a current diagnosis of schizophrenia or schizoaffective disorder.
- Clinically stable as operationalized by (1) either having not been hospitalized within 3 months or having been hospitalized for 3 months or more prior to assessment, and (2) having had no change in antipsychotic medication dosage within the 4 weeks prior to assessment.
- Willingness and ability to speak English
- Willingness to provide informed consent
- Corrected visual ability that enables reading of newspaper headlines and corrected hearing capacity that is adequate to respond to a raised conversational voice.
- Age 18 or above
- Willingness and ability to speak English
- Willingness to provide informed consent
- Corrected visual ability that enables reading of newspaper headlines and corrected hearing capacity that is adequate to respond to a raised conversational voice.
Age in the registry: 18 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre for Addiction and Mental Health Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.