NCT01590862Completed
ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators
Source: ClinicalTrials.gov · Last updated 28 Apr 2026
Brief summary (registry, in English)
We propose to study approach/avoidance behavior as measured by the Approach Avoidance task in 20 epilepsy patients undergoing implementation of depth electrodes for seizure monitoring in the Epilepsy Monitoring Unit at MGH. We will also study the effects of VC/VS electrical stimulation on approach-avoidance conflict in 20 adult patients who have undergone DBS implantation for severe MDD and/or OCD. There are 100-200 patients in the world with DBS electrodes in the VC/VS, and our research team cares for more than any other institution. Both participant groups will be assessed with respect to reward-aversion decision conflict using the task. The task will be performed with concurrent EEG recordings in DBS patients, and with continuous recording through our invasive neurophysiology rig in EMU subjects.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 13 (actual)
- First submitted
- 27 Apr 2012
- Start date
- 23 Jan 2021
- Primary completion date
- 31 Mar 2026
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Epilepsy, Depression
- NCT number
- NCT01590862
What you commit to
- Study type: Interventional
- Participants enrolled: 13
- From 23 Jan 2021 to the primary completion date, 31 Mar 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Dementia or other known cognitive deficit
- Psychiatric Patients:
- Clinical history of bipolar disorder
- Current or past psychotic disorder
- Cognitive impairment that would affect a participant's ability to give informed consent
- Clinical history of severe personality disorder
- Evidence of dementia or other significant cognitive impairment on neuropsychological evaluation
Other
- Subjects unable to visualize stimulus objects with correction
- Gross structural brain damage
- Current substance abuse, or abuse within the past 3 months
- Imminent risk of suicide or an inability to control suicide attempts
Who the study is looking for
- Deep brain stimulator implantation performed at least three months prior to study
- Right-handed (as determined by the Handedness Inventory; Oldfield,1971)
- Normal or corrected-to normal vision and hearing
- Current diagnosis of MDD or OCD
Criteria the registry did not label
- DBS Patients:
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Charlestown | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.