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NCT01712490CompletedPhase 3

A Frontline Therapy Trial in Participants With Advanced Classical Hodgkin Lymphoma

A Randomized, Open-label, Phase 3 Trial of A+AVD Versus ABVD as Frontline Therapy in Patients With Advanced Classical Hodgkin Lymphoma

Source: ClinicalTrials.gov · Last updated 27 Feb 2026

Brief summary (registry, in English)

This open-label, randomized, 2-arm, multicenter, phase 3 study has the primary objective of comparing the modified progression-free survival (mPFS) obtained with brentuximab vedotin (ADCETRIS®) plus AVD (doxorubicin \[Adriamycin\], vinblastine, and dacarbazine; abbreviated A+AVD) versus that obtained with ABVD (doxorubicin \[Adriamycin\],bleomycin, vinblastine, and dacarbazine) for the frontline treatment of advanced classical Hodgkin lymphoma(HL)

Status (registry)
Completed
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
1334 (actual)
First submitted
19 Oct 2012
Start date
Nov 2012
Primary completion date
Apr 2017
Lead sponsor
Takeda
NCT number
NCT01712490
EU CT number
2023-506419-16-00
EudraCT number
2011-005450-60

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 1334
  • From Nov 2012 to the primary completion date, Apr 2017
  • 212 sites in 21 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Prior immunosuppressive chemotherapy, therapeutic radiation, or any immunotherapy within 12 weeks of first study drug dose.

Other illness

  • Cerebral/meningeal disease, including signs and symptoms of progressive multifocalleukoencephalopathy (PML).
  • Known human immunodeficiency virus (HIV) positive.
  • Known hepatitis B surface antigen-positive, or known or suspected active hepatitis C infection.
    • Please note that there are additional exclusion criteria. The study center will determine if you meet all of the criteria.

Lab values

  • Nodular lymphocyte predominant Hodgkin lymphoma.

Other

  • Sensory or motor peripheral neuropathy.

Who the study is looking for

  • Treatment-naïve participants with Ann Arbor Stage III or IV HL.
  • Histologically confirmed classical Hodgkin Lymphoma (HL) according to the current World Health Organization (WHO) classification.
  • Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to (\<=) 2.
  • Bidimensional measurable disease as documented by radiographic technique per the International Working Group Revised Criteria for Response Assessment for Malignant Lymphoma.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (212)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
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Bedford ParkAustraliaUnknown status
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East MelbourneAustraliaUnknown status
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GeelongAustraliaUnknown status
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HeidelbergAustraliaUnknown status
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HobartAustraliaUnknown status
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KingswoodAustraliaUnknown status
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ParkvilleAustraliaUnknown status
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PerthAustraliaUnknown status
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South BrisbaneAustraliaUnknown status
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St LeonardsAustraliaUnknown status
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WestmeadAustraliaUnknown status
Het Ziekenhuisnetwerk Antwerpen
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AntwerpBelgiumCompleted
Az St-Jan Brugge-Oostende A.V.
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BruggeBelgiumCompleted
Universitair Ziekenhuis Gent
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GentBelgiumCompleted
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CuritibaBrazilUnknown status
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Porto AlegreBrazilUnknown status
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Rio de JaneiroBrazilUnknown status
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SalvadorBrazilUnknown status
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Santo AndréBrazilUnknown status
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São PauloBrazilUnknown status
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EdmontonCanadaUnknown status
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HalifaxCanadaUnknown status
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MontrealCanadaUnknown status
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SaskatoonCanadaUnknown status
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TorontoCanadaUnknown status
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VancouverCanadaUnknown status
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WinnipegCanadaUnknown status
Vseobecna fakultni nemocnice v Praze
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PragueCzechiaCompleted
Fakultní Nemocnice Královské Vinohrady
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Prague 10CzechiaCompleted
Aarhus Universitetshospital
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Aarhus NDenmarkCompleted
Rigshospitalet
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Copenhagen OeDenmarkCompleted
Region Sjaelland
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RoskildeDenmarkCompleted
Institut Catala d'Oncologia
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BadalonaSpainCompleted
Hospital de la Santa Creu i Sant Pau
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BarcelonaSpainCompleted
Hospital del Mar
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BarcelonaSpainCompleted
Hospital Universitari Dexeus Grupo Quironsalud
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BarcelonaSpainCompleted
Hospital Clinic de Barcelona
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BarcelonaSpainCompleted
Hospital Costa del Sol
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MarbellaSpainCompleted
Hospital Universitario de Navarra
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PamplonaSpainCompleted
Hospital Universitario De Salamanca
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SalamancaSpainCompleted
Complexo Hospitalario Universitario De Santiago
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Santiago de CompostelaSpainCompleted
Hospital Clinico Universitario de Valencia
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ValenciaSpainCompleted
Centre Hospitalier Victor Dupouy
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Argenteuil CedexFranceCompleted
Centre Hospitalier Universitaire Grenoble Alpes
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Grenoble Cedex 9FranceCompleted
Centre Hospitalier Et Universitaire de Limoges
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LimogesFranceCompleted
Assistance Publique Hopitaux de Paris
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ParisFranceCompleted
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AberdeenUnited KingdomUnknown status
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BirminghamUnited KingdomUnknown status
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CanterburyUnited KingdomUnknown status
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CardiffUnited KingdomUnknown status
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ExeterUnited KingdomUnknown status
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GlasgowUnited KingdomUnknown status
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InvernessUnited KingdomUnknown status
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LeicesterUnited KingdomUnknown status
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LincolnUnited KingdomUnknown status
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LiverpoolUnited KingdomUnknown status
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LondonUnited KingdomUnknown status
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ManchesterUnited KingdomUnknown status
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NorfolkUnited KingdomUnknown status
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NorthwoodUnited KingdomUnknown status
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NottinghamUnited KingdomUnknown status
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OxfordUnited KingdomUnknown status
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RomfordUnited KingdomUnknown status
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SouthamptonUnited KingdomUnknown status
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SuttonUnited KingdomUnknown status
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TruroUnited KingdomUnknown status
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Hong KongHong Kong SAR ChinaUnknown status
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Lai Chi KokHong Kong SAR ChinaUnknown status
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TuenmenHong Kong SAR ChinaUnknown status
Del-Pesti Centrumkorhaz Orszagos Hematologiai Es Infektologiai Intezet
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Budapest IXHungaryCompleted
Orszagos Onkologiai Intezet
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Budapest XIIHungaryCompleted
University of Debrecen
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DebrecenHungaryCompleted
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz
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GyőrHungaryCompleted
University of Pecs
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PécsHungaryCompleted
University of Szeged
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SzegedHungaryCompleted
Azienda Ospedaliera Nazionale Ss Antonio E Biagio E C Arrigo Alessandria
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AlexandriaItalyCompleted
Azienda Ospedaliero-Universitaria delle Marche
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AnconaItalyCompleted
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
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BolognaItalyCompleted
ARNAS G. Brotzu
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CagliariItalyCompleted
IRCCS Ospedale Policlinico San Martino
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GenoaItalyCompleted
Fondazione IRCCS - Istituto Nazionale dei Tumori
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MilanItalyCompleted
Azienda Ospedaliero - Universitaria di Modena
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ModenaItalyCompleted
Azienda Ospedaliera Universitaria Federico II Di Napoli
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NaplesItalyCompleted
IRCCS Centro Di Riferimento Oncologico Della Basilicata
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Rionero in VultureItalyCompleted
I.F.O. Istituti Fisioterapici Ospitalieri
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RomeItalyCompleted
Humanitas Research Hospital
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RozzanoItalyCompleted
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Aoba-kuJapanUnknown status
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Chikusa-kuJapanUnknown status
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ChūōkuJapanUnknown status
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HigashikuJapanUnknown status
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Isehara-shiJapanUnknown status
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KōtokuJapanUnknown status
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MinamikuJapanUnknown status
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ShōwamachiJapanUnknown status
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SuitaJapanUnknown status
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BusanSouth KoreaUnknown status
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DaeguSouth KoreaUnknown status
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Goyang-siSouth KoreaUnknown status
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Hwasun-gunSouth KoreaUnknown status
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IncheonSouth KoreaUnknown status
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JeonjuSouth KoreaUnknown status
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Seocho-guSouth KoreaUnknown status
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SeoulSouth KoreaUnknown status
Oslo University Hospital HF
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OsloNorwayCompleted
Pratia S.A.
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CracowPolandCompleted
Uniwersyteckie Centrum Kliniczne
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GdanskPolandCompleted
Samodzielny Publiczny Szpital Kliniczny Im.Andrzeja Mieleckiego SUM W Katowicach
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KatowicePolandCompleted
Wojewódzki Szpital Specjalistyczny im. M. Kopernika w Łodzi
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ŁódźPolandCompleted
Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji z Warmińsko - Mazurskim Centrum Onkologii w Olsztynie
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OlsztynPolandCompleted
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy
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WarsawPolandCompleted
Instytut Hematologii I Transfuzjologii
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WarsawPolandCompleted
Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu
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WroclawPolandCompleted
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Kazan'RussiaUnknown status
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MoscowRussiaUnknown status
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MoskvaRussiaUnknown status
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Saint PetersburgRussiaUnknown status
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UfaRussiaUnknown status
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ChanghuaTaiwanUnknown status
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Chiayi County 613TaiwanUnknown status
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TainanTaiwanUnknown status
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TaipeiTaiwanUnknown status
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Taoyuan CountyTaiwanUnknown status
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AlbanyUnited StatesUnknown status
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AlbuquerqueUnited StatesUnknown status
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Ann ArborUnited StatesUnknown status
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AustinUnited StatesUnknown status
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BaltimoreUnited StatesUnknown status
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Basking RidgeUnited StatesUnknown status
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BethesdaUnited StatesUnknown status
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BirminghamUnited StatesUnknown status
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BismarckUnited StatesUnknown status
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BostonUnited StatesUnknown status
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BurbankUnited StatesUnknown status
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CharlestonUnited StatesUnknown status
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CharlotteUnited StatesUnknown status
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ChattanoogaUnited StatesUnknown status
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ChicagoUnited StatesUnknown status
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CincinnatiUnited StatesUnknown status
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Colorado SpringsUnited StatesUnknown status
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ColumbusUnited StatesUnknown status
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CommackUnited StatesUnknown status
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DallasUnited StatesUnknown status
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DenverUnited StatesUnknown status
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DetroitUnited StatesUnknown status
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DuarteUnited StatesUnknown status
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EugeneUnited StatesUnknown status
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FairfaxUnited StatesUnknown status
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FairwayUnited StatesUnknown status
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Fort MyersUnited StatesUnknown status
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Fort WayneUnited StatesUnknown status
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FresnoUnited StatesUnknown status
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FullertonUnited StatesUnknown status
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GilbertUnited StatesUnknown status
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GoshenUnited StatesUnknown status
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GreenvilleUnited StatesUnknown status
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HackensackUnited StatesUnknown status
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HersheyUnited StatesUnknown status
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HoustonUnited StatesUnknown status
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IndianapolisUnited StatesUnknown status
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Iowa CityUnited StatesUnknown status
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JacksonvilleUnited StatesUnknown status
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KennewickUnited StatesUnknown status
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KnoxvilleUnited StatesUnknown status
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La JollaUnited StatesUnknown status
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Las VegasUnited StatesUnknown status
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LawrencevilleUnited StatesUnknown status
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LincolnUnited StatesUnknown status
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LonetreeUnited StatesUnknown status
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Long BeachUnited StatesUnknown status
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Los AngelesUnited StatesUnknown status
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MaywoodUnited StatesUnknown status
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MiamiUnited StatesUnknown status
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MilwaukeeUnited StatesUnknown status
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MinneapolisUnited StatesUnknown status
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MorgantownUnited StatesUnknown status
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MorristownUnited StatesUnknown status
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NashvilleUnited StatesUnknown status
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New YorkUnited StatesUnknown status
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NilesUnited StatesUnknown status
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Oklahoma CityUnited StatesUnknown status
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OmahaUnited StatesUnknown status
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OrlandoUnited StatesUnknown status
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PhiladelphiaUnited StatesUnknown status
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RaleighUnited StatesUnknown status
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RichmondUnited StatesUnknown status
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RochesterUnited StatesUnknown status
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Rockville CentreUnited StatesUnknown status
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SacramentoUnited StatesUnknown status
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Salt Lake CityUnited StatesUnknown status
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San AntonioUnited StatesUnknown status
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San Luis ObispoUnited StatesUnknown status
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Santa BarbaraUnited StatesUnknown status
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Santa MonicaUnited StatesUnknown status
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SeattleUnited StatesUnknown status
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SpringfieldUnited StatesUnknown status
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StanfordUnited StatesUnknown status
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St LouisUnited StatesUnknown status
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The BronxUnited StatesUnknown status
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TucsonUnited StatesUnknown status
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TylerUnited StatesUnknown status
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VancouverUnited StatesUnknown status
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Washington D.C.United StatesUnknown status
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YakimaUnited StatesUnknown status
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ZionUnited StatesUnknown status
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BloemfonteinSouth AfricaUnknown status
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Cape TownSouth AfricaUnknown status
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eManzimtotiSouth AfricaUnknown status
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JohannesburgSouth AfricaUnknown status
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PretoriaSouth AfricaUnknown status
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AnkaraTurkey (Türkiye)Unknown status
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IstanbulTurkey (Türkiye)Unknown status
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SamsunTurkey (Türkiye)Unknown status

This page is information, not medical advice. Discuss any trial with your doctor.