NCT01796457Active, not recruiting
HBRN: Immune Regulation and Costimulation in Natural History and Therapeutic Outcome of Chronic Hepatitis B
Source: ClinicalTrials.gov · Last updated 22 Jan 2026
Brief summary (registry, in English)
This is an ancillary to the NIDDK-sponsored treatment trials titled: Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B (NCT01369212) and Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults With Chronic Hepatitis B (NCT01369199). This study will examine the balance between immune regulatory and effector responses in hepatitis B-infected participants enrolled in the HBRN's clinical trials (NCT01369212 and NCT01369199) to define natural history and treatment outcome.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 40 (actual)
- First submitted
- 19 Feb 2013
- Start date
- Mar 2013
- Primary completion date
- Dec 2026
- Lead sponsor
- University of Pennsylvania
- Diseases
- Hepatitis B
- NCT number
- NCT01796457
What you commit to
- Study type: Observational
- Participants enrolled: 40
- From Mar 2013 to the primary completion date, Dec 2026
- 8 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Participants with active medical conditions such as congestive heart failure or chronic lung disease requiring oxygen, active coronary artery disease with unstable angina, sepsis and renal failure
- Participants with significant medical conditions, autoimmune disease or immunosuppression
Age
- Children under 18 years of age
Other
- Pregnant women
- Participants with anemia (Hgb\<10 or Hct\<30)
Who the study is looking for
- Ability to provide informed consent for participation in the ancillary study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Toronto Western Hospital Liver Centre Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Beth Israel Deaconess Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| University of Minnesota Coordinator of this site? Confirm its status | Plymouth | United States | Unknown status |
| Virginia Commonwealth University Medical Center Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| University of California San Francisco Medical Center Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
| California Pacific Medical Center Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
| Harborview Medical Center Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Virginia Mason Medical Center Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.