NCT01808937Recruiting
Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
Immunologic and Genetic Profiles in Subsets of Morphea Patients
Source: ClinicalTrials.gov · Last updated 12 May 2026
Brief summary (registry, in English)
The Morphea in Adults and Children (MAC) cohort is the first registry for both children and adults with morphea (also known as localized scleroderma) in the country. The purpose of the registry is to learn more about morphea, specifically: * How morphea behaves over time * How frequently specific problems occur along with morphea (for example, arthritis) * Whether morphea has an autoimmune background
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 25 Feb 2013
- Start date
- May 2007
- Primary completion date
- Jan 2027
- Lead sponsor
- University of Texas Southwestern Medical Center
- Diseases
- Systemic sclerosis (scleroderma)
- NCT number
- NCT01808937
What you commit to
- Study type: Observational
- Planned participants: 500
- From May 2007 to the primary completion date, Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- \- Patients who have been coded as morphea (701.0), but do not have morphea/localized scleroderma (examples: steroid atrophy, acquired keratoderma, keloids, nephrogenic fibrosing dermopathy, systemic sclerosis, lichen sclerosis)
Who the study is looking for
- Patient must have a clinical diagnosis of morphea confirmed by the primary investigator and by histopathological examination.
- Ages 0-90 years old
- Children must weigh more than 20 lbs. in order to satisfy Children's Medical Center policy for the maximum amount of blood drawn in a 24 hour period.
- Patient or legal guardian must be able to speak and read at a 6th grade reading level.
- Both male and female patients will be eligible
- All races and ethnic backgrounds will be included
- Relationships to proband: All patients with morphea will be included. A patient's family history will be reviewed and if there is a family history of morphea or systemic sclerosis then we will give the study patient the investigator's contact information and ask the family member to call the study team to answer any questions and enroll them in the study if they choose to do so.
- Ability to give informed consent: Patients must be able to give informed consent or they will give assent with parent or guardian consent as a minor to be a part of the morphea registry.
Age in the registry: - to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UT Southwestern Medical Center - Department of Dermatology Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.