NCT01949129RecruitingPhase 2/3
Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia
Source: ClinicalTrials.gov · Last updated 4 Sept 2026
Brief summary (registry, in English)
The ALL SCTped 2012 FORUM is a multinational, multi-centre, controlled, prospective phase III study for the therapy and therapy optimisation for children and adolescents with ALL in complete morphological remission (CR, less than 5% bone marrow blasts, no blasts in cerebrospinal fluid, no other extramedullary leukemia), who have an indication for HSCT with a myeloablative conditioning regimen. The stratification of patients in first and following remissions according to the individual transplantation modalities rests upon an indication for allogeneic HSCT and the availability of a suitable donor within the individual transplantation groups.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 1800 (estimated)
- First submitted
- 9 Sept 2013
- Start date
- 1 Apr 2013
- Primary completion date
- 1 Jun 2030
- Lead sponsor
- St. Anna Kinderkrebsforschung
- NCT number
- NCT01949129
- EU CT number
- 2024-512657-24-00
- EudraCT number
- 2012-003032-22
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 1800
- From 1 Apr 2013 to the primary completion date, 1 Jun 2030
- 110 sites in 31 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- severe concomitant disease that does not allow treatment according to the protocol at the investigator's discretion (e.g. malformation syndromes, cardiac malformations, metabolic disorders)
Other
- patients who do not fulfil the inclusion criteria
- Non Hodgkin-Lymphoma
- the whole protocol or essential parts are declined either by patient himself/herself or the respective legal guardian
- no consent is given for saving and propagation of anonymous medical data for study reasons
- Karnofsky / Lansky score \< 50%
- subjects unwilling or unable to comply with the study procedures
Who the study is looking for
- Patients with ALL (except for patients with B-ALL) who fulfil the following criteria:
- age at diagnosis ≤ 18 years. Age at HSCT ≤ 21 years
- indication for allogeneic HSCT
- complete remission (CR) before HSCT
- written consent of the parents (legal guardian) and, if necessary, the minor patient via "Informed Consent Form"
- no pregnancy
- no secondary malignancy
- no previous HSCT
- HSCT is performed in a study participating centre
Age in the registry: 1 month to 18 years · Sex: All · Does not accept healthy volunteers
Sites (110)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital de Pediatria "Juan P. Garrahan" Combate de Los Pozos N°1800 CABA Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Recruiting |
| Hospital Sor Maria Ludovica, Department Hematology Stem Cell Transplant Unit Coordinator of this site? Confirm its status | La Plata | Argentina | Recruiting |
| Medical University of Graz Coordinator of this site? Confirm its status | Graz | Austria | Recruiting |
| Medizinische Universitaet Innsbruck Coordinator of this site? Confirm its status | Innsbruck | Austria | Recruiting |
| St. Anna Kinderspital GmbH Coordinator of this site? Confirm its status | Vienna | Austria | Recruiting |
| Children's Cancer Centre The Royal Children's Hospital Coordinator of this site? Confirm its status | Melbourne | Australia | Active, not recruiting |
| Princess Margaret Hospital for Children Coordinator of this site? Confirm its status | Perth | Australia | Active, not recruiting |
| Sydney Children's Hospital Coordinator of this site? Confirm its status | Randwick | Australia | Active, not recruiting |
| Lady Cilento Children's Hospital Coordinator of this site? Confirm its status | South Brisbane | Australia | Active, not recruiting |
| The Children's Hospital at Westmead Oncology Unit Coordinator of this site? Confirm its status | Sydney | Australia | Active, not recruiting |
| Association Hospitaliere De Bruxelles Hopital Universitaire Des Enfants Reine Fabiola Coordinator of this site? Confirm its status | Brussels | Belgium | Recruiting |
| Universitair Ziekenhuis Gent Coordinator of this site? Confirm its status | Gent | Belgium | Recruiting |
| UZ Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Recruiting |
| Centre Hospitalier Universitaire de Liège Coordinator of this site? Confirm its status | Liège | Belgium | Recruiting |
| Cliniques Universitaires Saint-Luc Coordinator of this site? Confirm its status | Sint-Lambrechts-Woluwe | Belgium | Recruiting |
| Belarusian Research Center for Pediatric Oncology, Hematology and Immunology Coordinator of this site? Confirm its status | Minsk | Belarus | Active, not recruiting |
| Alberta Children's Hospital Division of Pediatric Oncology Coordinator of this site? Confirm its status | Calgary | Canada | Active, not recruiting |
| Montreal Children's Hospital Coordinator of this site? Confirm its status | Montral | Canada | Active, not recruiting |
| CHU Sainte-Justine Hematology-Oncology Division Coordinator of this site? Confirm its status | Montreal | Canada | Active, not recruiting |
| Hospital for Sick Children University of Toronto Division of Haematology/Oncology Coordinator of this site? Confirm its status | Toronto | Canada | Completed |
| BC Children ' s Hospital Coordinator of this site? Confirm its status | Vancouver | Canada | Completed |
| CancerCare Manitoba/University of Manitoba Coordinator of this site? Confirm its status | Winnipeg | Canada | Withdrawn |
| Universitäts-Kinderspital beider Basel (UKBB) Coordinator of this site? Confirm its status | Basel | Switzerland | Recruiting |
| HUG Hôpitaux Universitaire de Genève Coordinator of this site? Confirm its status | Geneva | Switzerland | Recruiting |
| Universitäts-Kinderspital Zürich Coordinator of this site? Confirm its status | Zurich | Switzerland | Recruiting |
| Hospital Dr Luis Calvo Mackenna Coordinator of this site? Confirm its status | Santiago | Chile | Recruiting |
| Fakultni nemocnice v Motole Coordinator of this site? Confirm its status | Prague | Czechia | Recruiting |
| Universitaetsklinikum Aachen AöR Coordinator of this site? Confirm its status | Aachen | Germany | Active, not recruiting |
| Charite Universitaetsmedizin Berlin KöR Coordinator of this site? Confirm its status | Berlin | Germany | Active, not recruiting |
| Universitaetsklinikum Bonn AöR Coordinator of this site? Confirm its status | Bonn | Germany | Active, not recruiting |
| Universitaetsklinikum Duesseldorf AöR Coordinator of this site? Confirm its status | Duesseldorf | Germany | Active, not recruiting |
| Universitaetsklinikum Erlangen AöR Coordinator of this site? Confirm its status | Erlangen | Germany | Active, not recruiting |
| Universitaetsklinikum Essen (AoR) Coordinator of this site? Confirm its status | Essen | Germany | Active, not recruiting |
| Goethe University Frankfurt Coordinator of this site? Confirm its status | Frankfurt Am Main | Germany | Active, not recruiting |
| Medical Center- University of Freiburg Coordinator of this site? Confirm its status | Freiburg im Breisgau | Germany | Active, not recruiting |
| Universitaetsklinikum Giessen und Marburg GmbH Coordinator of this site? Confirm its status | Giessen | Germany | Active, not recruiting |
| Universitaetsmedizin Greifswald KöR Coordinator of this site? Confirm its status | Greifswald | Germany | Active, not recruiting |
| Martin-Luther-Universitaet Halle-Wittenberg Coordinator of this site? Confirm its status | Halle (Saale) | Germany | Active, not recruiting |
| University Medical Center Hamburg-Eppendorf Coordinator of this site? Confirm its status | Hamburg | Germany | Active, not recruiting |
| Medizinische Hochschule Hannover Coordinator of this site? Confirm its status | Hanover | Germany | Active, not recruiting |
| Universitaetsklinikum Heidelberg AöR Coordinator of this site? Confirm its status | Heidelberg | Germany | Active, not recruiting |
| Universitaetsklinikum Jena KöR Coordinator of this site? Confirm its status | Jena | Germany | Active, not recruiting |
| Universitaetsklinikum Schleswig-Holstein AöR Coordinator of this site? Confirm its status | Kiel | Germany | Active, not recruiting |
| Universitaet Leipzig Coordinator of this site? Confirm its status | Leipzig | Germany | Active, not recruiting |
| Universitaet Muenster Coordinator of this site? Confirm its status | Muenster | Germany | Active, not recruiting |
| Klinikum der Universitaet Muenchen AöR Coordinator of this site? Confirm its status | Munich | Germany | Active, not recruiting |
| Klinikum rechts der Isar der TU Muenchen AöR Coordinator of this site? Confirm its status | Munich | Germany | Active, not recruiting |
| Universitaetsklinikum Regensburg AöR Coordinator of this site? Confirm its status | Regensburg | Germany | Active, not recruiting |
| Universitaetsklinikum Tuebingen AöR Coordinator of this site? Confirm its status | Tuebingen | Germany | Active, not recruiting |
| Universitaetsklinikum Ulm AoR Coordinator of this site? Confirm its status | Ulm | Germany | Active, not recruiting |
| Universitaetsklinikum Wuerzburg AöR Coordinator of this site? Confirm its status | Wuerzburg | Germany | Active, not recruiting |
| Rigshospitalet Coordinator of this site? Confirm its status | Copenhagen Oe | Denmark | Recruiting |
| Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital de la Santa Creu i Sant Pau Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| University Clinical Hospital Virgen De La Arrixaca Coordinator of this site? Confirm its status | Murcia | Spain | Recruiting |
| Hospital Universitario Central De Asturias Coordinator of this site? Confirm its status | Oviedo | Spain | Recruiting |
| Division of Hematology-Oncology and Stem Cell Transplantation, Hospital for Children and Adolescents, Univ. of Helsinki Coordinator of this site? Confirm its status | Helsinki | Finland | Completed |
| Centre hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Active, not recruiting |
| University Hospital Of Clermont-Ferrand Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Active, not recruiting |
| Centre Hospitalier Universitaire Grenoble Alpes Coordinator of this site? Confirm its status | La Tronche | France | Active, not recruiting |
| Centre Hospitalier Universitaire De Lille Coordinator of this site? Confirm its status | Lille Cedex | France | Active, not recruiting |
| Hospices Civils de Lyon Coordinator of this site? Confirm its status | Lyon | France | Active, not recruiting |
| Centre Hospitalier Regional De Marseille Coordinator of this site? Confirm its status | Marseille | France | Active, not recruiting |
| Centre Hospitalier Universitaire De Montpellier Coordinator of this site? Confirm its status | Montpellier Cedex 5 | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Nantes Coordinator of this site? Confirm its status | Nantes | France | Active, not recruiting |
| Robert Debre University Hospital Coordinator of this site? Confirm its status | Paris | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Rennes Coordinator of this site? Confirm its status | Rennes | France | Active, not recruiting |
| Centre Hospitalier Universitaire Rouen Coordinator of this site? Confirm its status | Rouen Cedex | France | Active, not recruiting |
| Les Hopitaux Universitaires De Strasbourg Coordinator of this site? Confirm its status | Strasbourg Cedex 2 | France | Active, not recruiting |
| CHRU De Nancy Coordinator of this site? Confirm its status | Vandoeuvre Les Nancy Cedex | France | Active, not recruiting |
| Saint Sophia Children's Hospital BMT Unit Coordinator of this site? Confirm its status | Athens | Greece | Recruiting |
| Department of Pediatrics, UHC Zagreb Coordinator of this site? Confirm its status | Zagreb | Croatia | Recruiting |
| National Institute of Haematology and Infectious Disease, Hospital of Southern Pest, Paediatric Bone Marrow Transplantation Unit Coordinator of this site? Confirm its status | Budapest | Hungary | Recruiting |
| Rambam Medical Center Coordinator of this site? Confirm its status | Haifa | Israel | Active, not recruiting |
| Schneider Children's Medical Center of Israel Coordinator of this site? Confirm its status | Petah Tikva | Israel | Active, not recruiting |
| Dana Children's Hospital Coordinator of this site? Confirm its status | Tel Aviv | Israel | Active, not recruiting |
| Fondazione IRCCS San Gerardo dei Tintori Coordinator of this site? Confirm its status | Monza | Italy | Recruiting |
| Fondazione IRCCS Policlinico San Matteo Coordinator of this site? Confirm its status | Pavia | Italy | Recruiting |
| Ospedale Pediatrico Bambino Gesù Coordinator of this site? Confirm its status | Rome | Italy | Recruiting |
| Instituto Nacional de Peditria Coordinator of this site? Confirm its status | Mexico City | Mexico | Recruiting |
| University of Malaya, Department of Paediatrics Coordinator of this site? Confirm its status | Kuala Lumpur | Malaysia | Recruiting |
| Prinses Maxima Centrum voor Kinderoncologie B.V. Coordinator of this site? Confirm its status | Utrecht | Netherlands | Recruiting |
| Oslo University Hospital HF Coordinator of this site? Confirm its status | Oslo | Norway | Recruiting |
| Starship Children's Hospital Coordinator of this site? Confirm its status | Auckland | New Zealand | Active, not recruiting |
| University Hospital No.1, Collegium Medicum UMK, department of Paediatrics, Oncology, Hematology and Paediatric Transplantology Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Active, not recruiting |
| University Children's Hospital in Krakow, Department of Transplantation Coordinator of this site? Confirm its status | Krakow | Poland | Withdrawn |
| Children's University Hospital, Dept. Pediatric Hematology, Oncology, and Transplantology Coordinator of this site? Confirm its status | Lublin | Poland | Active, not recruiting |
| Poznan University of Medical Sciences, Department of Pediatric Onology, Hematology & HSCT Coordinator of this site? Confirm its status | Poznan | Poland | Active, not recruiting |
| Cape of Hope, Wroclaw Medical University Coordinator of this site? Confirm its status | Wroclaw | Poland | Active, not recruiting |
| IInsitutul Clinic Fundeni, Sectia de Transplant Medular Coordinator of this site? Confirm its status | Bucharest | Romania | Active, not recruiting |
| University of Medicine and Pharmacy V. BABES, Emergency Children's Hospital LOUIS TURCANU, III. Clinic of Pediatrics , Department of Onco-hematology and Bone Marrow Transplantation Coordinator of this site? Confirm its status | Timișoara | Romania | Completed |
| King Abdullah specialists children hospital Coordinator of this site? Confirm its status | Riyadh | Saudi Arabia | Recruiting |
| Queen Silvia Childrens Hospital - Sahlgrenska University Hospital - Vaestra Goetalandsregionen Coordinator of this site? Confirm its status | Gothenburg | Sweden | Recruiting |
| Karolinska University Hospital Coordinator of this site? Confirm its status | Huddinge | Sweden | Recruiting |
| Region Skane Skanes Universitetssjukhus Coordinator of this site? Confirm its status | Lund | Sweden | Recruiting |
| Uppsala University Hospital Coordinator of this site? Confirm its status | Uppsala | Sweden | Recruiting |
| University childrens' hospital, UMCL Coordinator of this site? Confirm its status | Ljubljana | Slovenia | Recruiting |
| Narodny ustav detskych chorob Coordinator of this site? Confirm its status | Bratislava | Slovakia | Recruiting |
| Ankara University School of Medicine Pediatric Stem Cell Transplantation Unit Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Active, not recruiting |
| Gazi University School of Medicine Pediatric Stem Cell Transplantation Unit Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Active, not recruiting |
| Gulhane Training and Research Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Active, not recruiting |
| Akdeniz University School of Medicine Pediatric Stem Cell Transplantation Unit Coordinator of this site? Confirm its status | Antalya | Turkey (Türkiye) | Active, not recruiting |
| Bahcesehir University School of Medicine Pediatric Stem Cell Transplantation Unit Coordinator of this site? Confirm its status | Antalya | Turkey (Türkiye) | Active, not recruiting |
| Bahcelievler Medicalpark Hospital Pediatric Stem Cell Transplantation Unit Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Active, not recruiting |
| Medipol Mega Universite Hastanesi Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Active, not recruiting |
| Bahcesehir University School of Medicine Pediatric Stem Cell Transplantation Unit Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Active, not recruiting |
| Acibadem University Atakent Hospital Pediatric Stem Cell Transplantation Unit Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Active, not recruiting |
| Dokuzeylul University School of Medicine Pediatric Stem Cell Transplantation Unit Coordinator of this site? Confirm its status | Izmir | Turkey (Türkiye) | Active, not recruiting |
| Ege University School of Medicine Pediatric Stem Cell Transplantation Unit Coordinator of this site? Confirm its status | Izmir | Turkey (Türkiye) | Active, not recruiting |
| Erciyes University School of Medicine Pediatric Stem Cell Transplantation Unit Coordinator of this site? Confirm its status | Kayseri | Turkey (Türkiye) | Active, not recruiting |
Related publications
- Refining busulfan exposure enhances pediatric ALL HSCT outcomes: insights from the International FORUM study.Blood Adv · 2026 · PMID 41779961
- Outcomes of BCP-ALL with hypodiploidy or BCR::ABL1 fusion in children undergoing allogeneic HSCT: results from the FORUM study.Blood · 2026 · PMID 41259231
This page is information, not medical advice. Discuss any trial with your doctor.