NCT02081768RecruitingPhase 3
90Yttrium Colloid for the Treatment of Cystic Sellar/Parasellar Tumors
Assessment of the Efficacy of Stereotactic Intracavitary Instillation of 90yttrium Colloid for Treatment of Cystic Lesions of the Pituitary and Surrounding Areas (Sellar/Parasellar Region)
Source: ClinicalTrials.gov · Last updated 20 Feb 2026
Brief summary (registry, in English)
There is no consensus in the literature on the best way to treat cystic lesions of the pituitary area. Patients who are symptomatic from these tumours are rare. The cystic form of tumours present special challenges since traditional treatment modalities (surgery and/or external radiation) are often not able to completely remove or treat the cyst wall without major morbidity or even mortality. There is no 'best practice' for the treatment of cystic tumours per se. Treatments available to patients with cystic sellar/parasellar tumours include conservative management using a 'wait and scan' approach, cyst drainage, and cyst removal via transsphenoidal and/or craniotomy approach (i.e. open surgery). Over the last 10 years we have treated approximately 8 patients with intracystic radiotherapy. All of these patients continue to be monitored clinically and radiologically and all have done well with stable regression of the cysts and no new neurological deficits. Over the past 2 years, 90yttrium colloid has been provided to CDHA through Health Canada's Special Access Program (SAP). It has only been of recent that Health Canada has requested a clinical trial to assess the benefit of intracystic radiotherapy over other available treatment options. The experimental treatment being proposed is the stereotactic intracavitary instillation of 90yttrium colloid for treatment of cystic lesions of the pituitary (sellar) and surrounding areas (parasellar).
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 5 Mar 2014
- Start date
- Jun 2014
- Primary completion date
- 30 Jun 2031
- Lead sponsor
- David Clarke
- Diseases
- Childhood cancers
- NCT number
- NCT02081768
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 40
- From Jun 2014 to the primary completion date, 30 Jun 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Neurosurgeon's assessment that surgical procedures hold unacceptable operative risk.
- Pregnant or breast feeding at time of surgical consent and/or surgery.
Other illness
- Hypersensitivity, allergies or contraindication to the used radiopharmaceutical agent (90yttrium colloid).
Other
- Patients who meet any of these criteria are not eligible for enrollment as study participants:
- Having a solid tumour.
Who the study is looking for
- Patients who meet all of the following criteria are eligible for enrollment as study participants:
- Patients 17 years of age or older.
- Cystic sellar, suprasellar, parasellar or intrasellar masses diagnosed by histology, cytology or neuroimaging.
- Tumour measurements and/or tumour volume can be calculated.
- Patients who require surgical intervention as determined by the treating neurosurgeon.
- Being a patient managed in the Halifax Neuropituitary Program surgical clinic.
- Willingness to undergo surgery and give informed surgical consent.
- Willingness to provide informed consent for study participation.
Criteria the registry did not label
- Criteria
- Ages Eligible for Study: 17 years of age or older Genders Eligible for Study: Both Accepts Healthy Volunteers: No
Age in the registry: 17 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Halifax Infirmary Coordinator of this site? Confirm its status | Halifax | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.