NCT02087826Active, not recruiting
Study of Clinical Response to Acute Metformin By Leveraging Evaluations During a Mixed Meal Tolerance Test for Exploring Glycemia and GeneticS
Study of Clinical Response to Acute Metformin By Leveraging Evaluations During a Mixed Meal Tolerance Test for Exploring Glycemia and GeneticS (SCRAMBLED EGGS)
Source: ClinicalTrials.gov · Last updated 15 Jan 2026
Brief summary (registry, in English)
The purpose of this research study is to examine whether specific genes (e.g. SLC16A11) affect how human beings respond to food and a medication that is commonly used to treat type 2 diabetes. The food the investigators will be studying is specially prepared to contain protein, carbohydrate, and fat. The drug the investigators are studying is metformin. The investigators hypothesize that physiological responses to the meal and to the medication will differ between carriers and non-carriers of genes associated with type 2 diabetes.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 1017 (actual)
- First submitted
- 12 Mar 2014
- Start date
- Apr 2014
- Primary completion date
- Dec 2026
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Type 2 diabetes
- NCT number
- NCT02087826
What you commit to
- Study type: Interventional
- Participants enrolled: 1017
- From Apr 2014 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently taking any medications used for the treatment of diabetes
- Currently taking or intending to take during the study duration any medication known to affect glycemic parameters, such as glucocorticoids, growth hormone, or fluoroquinolones
- Planned changes to any prescribed medications, specifically diuretics, during study enrollment
Other illness
- Conditions causing intestinal malabsorption, including celiac disease or a history of intestinal or gastric bypass surgery
Lab values
- History of liver disease and/or aspartate aminotransferase (AST) or alanine aminotransferase (ALT) more than 3 times upper limit of normal (ULN)
- Estimated glomerular filtration rate (eGFR) \< 60 ml/min/1.73 m2 as calculated by the Modification of Diet in Renal Disease equation
Other
- Women who are pregnant, nursing, or at risk of becoming pregnant
- Contraindications to safe use of metformin, including planned radiologic or angiographic study requiring contrast within one week of the study completion
- Participation in any other interventional study during the study duration
- Dietary restrictions that would prevent consumption of a MMTT
- Objection or inability to take metformin
Who the study is looking for
- Adult males or non-pregnant females
- Age 18-79
- Able and willing to give consent relevant to genetic investigation
Age in the registry: 18 years to 79 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.