NCT02102113Active, not recruitingEarly phase 1
Probing the Cannabinoid System in Individuals With a Family History of Psychosis
Source: ClinicalTrials.gov · Last updated 10 Jun 2025
Brief summary (registry, in English)
The overall purpose of this study is to determine whether a family history of psychosis is associated with an altered cannabinoid system. This will be tested by studying individuals with and without a family history of psychosis and comparing their responses to delta 9-tetrahydrocannabinol (THC), a probe of the cannabinoid system. We hypothesize, that compared to controls with no family history of psychoses, individuals with a family history of psychoses will have an altered response to THC.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 21 (estimated)
- First submitted
- 26 Mar 2014
- Start date
- 1 Jan 2014
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- Yale University
- Diseases
- Schizophrenia
- NCT number
- NCT02102113
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 21
- From 1 Jan 2014 to the primary completion date, 30 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Current or lifetime major DSM-IV Axis I disorder
- Current or lifetime treatment (at least 6 months) with psychotropic medications for major psychiatric or neurological illness
- Major or unstable medical illness that might impact safety of the subject in the study
- Current or lifetime major DSM-IV Axis I disorder
- Current or lifetime treatment (at least 6 months) with psychotropic medications for major psychiatric or neurological illness
- Major or unstable medical illness that might impact safety of the subject in the study
Other
- Cannabis naive
- IQ less than 85
- Less than a high school diploma or its educational equivalent
- Pregnancy or lactation
- Major current or recent (\<6 weeks) psychosocial stressors.
- Having a family member with psychosis
- Cannabis naive
- IQ less than 85
- Less than a high school diploma or its educational equivalent
- Pregnancy or lactation
- Major current or recent (\<6 weeks) psychosocial stressors.
Who the study is looking for
- Exposure to cannabis at least once in their lifetime
- Medically and psychiatrically healthy based on screening
- Having one relative with a confirmed psychotic disorder
- Exposure to cannabis at least once in their lifetime
- Medically and psychiatrically healthy based on screening
Age in the registry: 18 years to 55 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA Connecticut Healthcare System Coordinator of this site? Confirm its status | West Haven | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.