NCT02105844Active, not recruiting
Swiss Atrial Fibrillation Cohort Study
Swiss Atrial Fibrillation Cohort Study - SWISS AF
Source: ClinicalTrials.gov · Last updated 9 Jul 2025
Brief summary (registry, in English)
Swiss-AF is a prospective observational, multicentric cohort study in Switzerland. Overall, 2600 patients with documented atrial fibrillation aged \>65 years will be included and followed on a yearly basis. Yearly clinical examinations include a detailed questionnaire on personal characteristics, a resting electrocardiogram, neurocognitive function tests and questionnaires on disability and quality of life. Blood sampling and brain magnetic resonance imaging are scheduled at baseline and after 2 years of follow-up. The main study aims of this long term prospective study are to increase our knowledge on structural brain damage and its changes over time in patients with atrial fibrillation, to gain additional insights on the incidence and underlying mechanisms of cognitive decline in patients with atrial fibrillation and to evaluate the interrelationships of structural and functional brain damage in this population.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 2415 (actual)
- First submitted
- 28 Mar 2014
- Start date
- Mar 2014
- Primary completion date
- Mar 2030
- Lead sponsor
- University Hospital, Basel, Switzerland
- Diseases
- Stroke, Atrial fibrillation
- NCT number
- NCT02105844
What you commit to
- Study type: Observational
- Participants enrolled: 2415
- From Mar 2014 to the primary completion date, Mar 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- acute illness
Other
- inability to provide informed consent
- Only short episodes of reversible forms of atrial fibrillation
Who the study is looking for
- atrial fibrillation documented within the last 24 months
- age \>=45 years
Age in the registry: 45 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Coordinator of this site? Confirm its status | Basel | Switzerland | Unknown status |
Related publications
- Impact of differences in kidney function estimation by creatinine compared to cystatin C on clinical outcomes in patients with atrial fibrillation.Eur Heart J Open · 2026 · PMID 42846172
- Progression of mitral and tricuspid regurgitation in patients with and without atrial fibrillation.Front Cardiovasc Med · 2026 · PMID 42459191
- Drug-drug interactions of NOACs with comedication: Prevalence and implications for adverse events in patients with atrial fibrillation.Heart Rhythm O2 · 2026 · PMID 42774679
- Brain lesions and cognitive decline in patients with atrial fibrillation: a prospective multicentre cohort study.Swiss Med Wkly · 2026 · PMID 41962126
- Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation.Nutrients · 2024 · PMID 38257071
This page is information, not medical advice. Discuss any trial with your doctor.