NCT02116335Active, not recruiting
Endothelin Receptor Function and Acute Stress
Endothelin Receptor Function and Acute Stress (End-Stress)
Source: ClinicalTrials.gov · Last updated 28 Jan 2025
Brief summary (registry, in English)
Our bodies respond differently to stress. Animal studies by the investigators have found that endothelin-1 plays a role in regulating blood pressure in response to stress. This study is an extension of the investigators previous animal work to evaluate the role of endothelin-1 during stress in humans.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 320 (estimated)
- First submitted
- 14 Apr 2014
- Start date
- 1 Jun 2015
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- Augusta University
- Diseases
- High blood pressure
- NCT number
- NCT02116335
What you commit to
- Study type: Interventional
- Planned participants: 320
- From 1 Jun 2015 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Using medications that affect vascular tone (i.e., nitrates, etc.)
- Using medications that are contraindicated with bosentan (i.e. glyburide, cyclosporine)
Other illness
- Having evidence of cardiovascular, pulmonary, renal, hepatic, cerebral, or metabolic disease
- Uncontrolled hypertension
- Having a history of chronic pain
- Having a history of rheumatoid arthritis
Other
- Having a BMI less than 16 kg/m2 (severely and very severely underweight) or that is greater than 40 kg/m2 (Class III obesity)
- Having evidence of pregnancy
- Postmenopausal women
- Individuals who are on a restricted salt diet
- Liver dysfunction (which may be identified with the blood sample we take)
Who the study is looking for
- Men and premenopausal women (Ages 18-50 years old)
- Self-reported Black and White adults
- Lean adults (BMl \<25 kg/m\^)
- Obese adults (BMl \> 30 kg/m\^)
Age in the registry: 18 years to 50 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Georgia Regents University Coordinator of this site? Confirm its status | Augusta | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.