NCT02119702Completed
Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)
Source: ClinicalTrials.gov · Last updated 27 Jun 2025
Brief summary (registry, in English)
This is a prospective cohort study designed to define the impact of HIV infection and antiretroviral therapy (ART) on young adults with perinatal HIV infection (YAPHIV) as they transition into adulthood. A group of of perinatally exposed but uninfected young adults from a similar sociodemographic background and age distribution will be enrolled for comparison.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 818 (actual)
- First submitted
- 10 Apr 2014
- Start date
- 1 Apr 2014
- Primary completion date
- 31 May 2025
- Lead sponsor
- Harvard School of Public Health (HSPH)
- Diseases
- HIV
- NCT number
- NCT02119702
What you commit to
- Study type: Observational
- Participants enrolled: 818
- From 1 Apr 2014 to the primary completion date, 31 May 2025
- 14 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- HIV acquired by other than maternal-child transmission (e.g., blood products, sexual contact, and IV drug use) as documented in the medical record
- Uninfected Cohort
- Have confirmed perinatal HIV infection as documented in the medical record
Who the study is looking for
- Perinatal HIV infection as documented in the medical record
- At or beyond their 18th birthday at the time of informed consent with no upper age limit
- Willing to provide access to existing medical records
- Available medical record documentation since early childhood of:
- ART exposure history
- Opportunistic infection prophylaxis exposure history
- Viral load and CD4+ cell count history
- Major medical events history
- Willingness to participate and provide legal written consent
- Absence of perinatal HIV infection as indicated in the medical record; the Perinatally HIV-Exposed Uninfected (PHEU) participant may have horizontally-acquired HIV infection
- At or beyond their 18th birthday at the time of informed consent with no upper age limit
- Willingness to participate and provide legal written consent
Criteria the registry did not label
- Perinatally HIV-Infected Cohort
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (14)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| San Juan Research Hospital Coordinator of this site? Confirm its status | San Juan | Puerto Rico | Unknown status |
| University of Colorado Denver Health Sciences Center Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Children's Hospital, Boston Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Ann and Robert H. Lurie Children's Hospital Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Children's Diagnostic and Treatment Center Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| Baylor College of Medicine Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| University of California San Diego Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| St. Jude Children's Research Hospital Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| University of Miami Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Rutgers New Jersey Medical School Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Tulane University Health Sciences Center Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| St. Christopher's Hospital for Children Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Bronx-Lebanon Hospital Center Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
| Jacobi Medical Center Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.