NCT02125786Active, not recruitingPhase 2
A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma
A Phase II Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma
Source: ClinicalTrials.gov · Last updated 24 Feb 2026
Brief summary (registry, in English)
The primary purpose of this study is to investigate whether surgery and re-irradiation will help treat ependymoma that has come back after initial treatment. The combined doses of the first and second courses of radiation are higher than what is usual standard of care. The investigators will study the effects and side effects of surgery and re-irradiation. They will also evaluate and study tumor tissue and blood to learn more about the tumor and how it does or does not respond to treatments and will use magnetic resonance imaging (MRI) and positron emission tomography (PET) scans to see if they can predict tumor response and tumor recurrence. Participants will be followed for up to 5 years following enrollment. Evaluations during radiation therapy will be done weekly while receiving therapy for up to 7 weeks. Other evaluations will be done at enrollment, every 4 months from enrollment through 3 years, and every 6 months during the 4th and 5th year.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 68 (actual)
- First submitted
- 25 Apr 2014
- Start date
- 7 May 2014
- Primary completion date
- May 2023
- Lead sponsor
- St. Jude Children's Research Hospital
- Diseases
- Childhood cancers
- NCT number
- NCT02125786
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 68
- From 7 May 2014 to the primary completion date, May 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior craniospinal irradiation
- Pregnant women are excluded from enrollment on this study because radiation therapy is an agent with the potential for teratogenic or abortifacient effects
Age
- Any patient with both metastatic ependymoma and age \< 3 years at the time of enrollment
Who the study is looking for
- Progressive intracranial ependymoma after prior focal irradiation
- Patients aged 1-21 years at the time of enrollment
- Adequate performance status (ECOG \< 3) and research participant does not require mechanical ventilation
- Interval from start of initial radiation therapy to enrollment \> 9 months
Age in the registry: 1 year to 21 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Jude Children's Research Hospital Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.