NCT02143414Active, not recruitingPhase 2
Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia
A Phase 2 Study of Blinatumomab and POMP (Prednisone, Vincristine, Methotrexate, 6-Mercaptopurine) for Patients >/= 65 Years of Age With Newly Diagnosed Philadelphia-Chromosome Negative (Ph-) Acute Lymphoblastic Leukemia (ALL) and of Dasatinib, Prednisone and Blinatumomab for Patients >/= 65 Years of Age With Newly Diagnosed Philadelphia-Chromosome Positive (Ph+) ALL, Relapsed/Refractory Ph+ ALL, and Philadelphia-Chromosome-Like Signature (Ph-Like) ALL (Newly Diagnosed or Relapsed/Refractory) With Known or Presumed Activating Dasatinib-Sensitive Mutations or Kinase Fusions (DSMKF)
Source: ClinicalTrials.gov · Last updated 4 Aug 2026
Brief summary (registry, in English)
This phase II trial studies the side effects and how well blinatumomab and combination chemotherapy or dasatinib, prednisone, and blinatumomab work in treating older patients with acute lymphoblastic leukemia. Immunotherapy with monoclonal antibodies, such as blinatumomab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as prednisone, vincristine sulfate, methotrexate, and mercaptopurine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving blinatumomab with combination chemotherapy or dasatinib and prednisone may kill more cancer cells.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 53 (actual)
- First submitted
- 19 May 2014
- Start date
- 30 Jun 2015
- Primary completion date
- 1 Jun 2022
- Lead sponsor
- National Cancer Institute (NCI)
- Diseases
- Acute lymphoblastic leukaemia
- NCT number
- NCT02143414
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 53
- From 30 Jun 2015 to the primary completion date, 1 Jun 2022
- 195 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Registration Step 1 - Induction/Re-Induction:
- Patients must have a new morphologic diagnosis of precursor B cell acute lymphoblastic leukemia (ALL) (non T cell) based on World Health Organization (WHO) criteria; patients with Burkitt's (L3) are excluded; patients with Ph-positive or Ph-like ALL with dasatinib-sensitive mutations or kinase fusions may have relapsed or refractory diagnoses
- NOTE: Relapsed/refractory Ph-positive patients or Ph-like patients with dasatinib-sensitive mutations or kinase fusions who have previous exposure to either dasatinib or another 2nd or 3rd generation tyrosine kinase inhibitor (TKI) will begin protocol therapy with Cohort 2: re-induction cycle 1
- Patients must have a diagnosis of Philadelphia chromosome negative ALL or Ph chromosome positive ALL by cytogenetics, fluorescence in situ hybridization (FISH) or polymerase chain reaction (PCR); patients will be registered to receive treatment in either Cohort 1 (Ph-) or Cohort 2 (Ph+ or Ph-like DSMKF) based on these results; diagnostic specimens must be submitted to the site's local Clinical Laboratory Improvement Amendments (CLIA)-approved cytogenetics laboratory and results of tests (cytogenetics, FISH or PCR) must confirm Ph status prior to registration; if not already known, breakpoint cluster region- abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) status (p190 or p210) must be evaluated in Ph-positive patients by PCR
- For Cohort 2, Ph-like testing is not required specifically for this study; however, to be registered to Cohort 2 under the Ph-like DSMKF criterion, the patient must have a known or presumed activating Ph-like signature and dasatinib-sensitive mutation or kinase fusion, such as: ABL1, ABL2, colony stimulating factor 1 receptor (CSF1R), platelet derived growth factor receptor beta (PDGFRB), platelet derived growth factor receptor alpha (PDGFRA), or fibroblast growth factor receptor (FGFR)s that was otherwise identified as part of normal standard of care; prior to registering any patients with a known or presumed activating Ph-like signature and dasatinib-sensitive mutations or kinase fusions (DSMKF) treating physicians must confirm eligibility with the study chairs via email; the study chairs must respond via email with confirmation of patient eligibility prior to patient registration
- All newly diagnosed patients must have evidence of ALL in their marrow or peripheral blood with at least 20% lymphoblasts present in blood or bone marrow collected within 28 days prior to registration; all relapsed/refractory patients (Cohort 2) must have at least 5% lymphoblasts present in blood or bone marrow collected within 28 days prior to registration; for relapsed/refractory patients, pathology and cytogenetics reports (both from time of original diagnosis) must be submitted at time of registration; if a bone marrow aspirate cannot be obtained despite an attempt (dry tap), appropriate immunohistochemistry (IHC) testing, including cluster of differentiation (CD)19, must be performed on the bone marrow biopsy to determine lineage; for ALL in marrow or peripheral blood, immunophenotyping of the blood or marrow lymphoblasts must be performed to determine lineage (B cell, T cell or mixed B/T cell); appropriate marker studies including CD19 (B cell), must be performed; co-expression of myeloid antigens (CD13 and CD33) will not exclude patients; if possible, the lineage specific markers (myeloid cells) should be determined; the blood/bone marrow sample for these assays must be obtained within 28 days prior to registration; patients with only extramedullary disease in the absence of bone marrow or blood involvement are not eligible
- Patient must not have a history or presence of clinically relevant central nervous system (CNS) pathology such as epilepsy, seizure, paresis, aphasia, stroke, severe brain injuries, dementia, Parkinson's disease, cerebellar disease, organic brain syndrome, psychosis, active ALL in the CNS confirmed by cerebrospinal fluid (CSF) analysis, or other significant CNS abnormalities
- Patients must have a lumbar puncture to determine CNS involvement of ALL within 14 days prior to registration; patients with CNS3 are excluded from the trial; patients with CNS1 or CNS2 will be eligible, but will be monitored for CNS involvement; note that intrathecal methotrexate administered during the pre-study lumbar puncture may count as the first dose of intrathecal therapy required as part of the study
- Cohort I, Ph-negative Patients Only: Patients must not have received any prior chemotherapy, radiation therapy, or other therapy for the treatment of ALL (other than those noted below) and must not be receiving any immunosuppressive therapy; patients may not have received any prior investigational therapy within 28 days prior to registration; patients must not have received any monoclonal antibody therapy within 42 days of registration; patients may have received the following within any time prior to registration: low dose chemotherapy-including: cyclophosphamide 1 g/m\^2, oral 6-mercaptopurine, or oral methotrexate (other low dose chemotherapy may be allowable, however any other options not listed here should be confirmed with the study chairs), TKI therapy, steroids, hydroxyurea, leukapheresis, intrathecal chemotherapy or vincristine
- Cohort I, Ph-negative Patients Only: In the event that the patient's bone marrow blast count is \>= 50% blasts, patients may be registered but should receive steroids for 3-5 days in order to reduce tumor burden prior to blinatumomab administration, as follows
- Prephase treatment with dexamethasone (10-20 mg/m\^2) for 3-5 days is required for patients with bone marrow blasts \>= 50%, peripheral blood blasts 15,000/uL or higher, or elevated lactate dehydrogenase (LDH) suggesting rapidly progressive disease per investigator opinion
- Pre-treatment should conclude at least 24 hours prior to the first dose of blinatumomab (although additional dexamethasone is automatically given as a pre-med prior to the first dose); at the time of first infusion of blinatumomab, the absolute peripheral blast count should be \< 25,000/uL
- Note: For the purposes of the study, day 1 of the cycle will be the first day of blinatumomab administration
- Cohort I, Ph-negative Patients Only: It is preferred, but not required, that corticosteroids and hydroxyurea should start only after all diagnostic samples have been obtained; however, if the patient was previously on corticosteroids and/or hydroxyurea, this is allowable provided that the patient still has measurable disease at time of the bone marrow aspirate
- Corticosteroids and/or hydroxyurea, as well as any of the other therapies mentioned (with the exception of IV cyclophosphamide), may continue to be administered, at physician discretion, until 1 day prior to blinatumomab administration
- IV cyclophosphamide must be discontinued at least 7 days prior to blinatumomab administration
- Cohort 2, Ph-positive and Ph-like DSMKF Patients Only: Patients must NOT have received a prior autologous or allogeneic hematopoietic stem cell transplant at any time. Patients must NOT have received any chemotherapy, investigational agents, or undergone major surgery within 14 days prior to registration, with the following exceptions:
- Monoclonal antibodies must not have been received for 1 week prior to registration
- Chimeric antigen receptor (CAR) T-cells must not have been received for 28 days prior to registration
- Steroids, hydroxyurea, vincristine, 6-mercaptopurine, methotrexate, thioguanine and intrathecal chemotherapy are permitted within any timeframe prior to registration; Food and Drug Administration (FDA)-approved TKIs may also be administered until 1 day prior to start of study therapy (C1, D1); IV cyclophosphamide may be administered at doses of 1 g/m\^2 or less until up to 7 days prior to registration
- Patients must be \>= 65 years of age; for patients 65-69 years of age, patient must be deemed not suitable for standard intensive induction chemotherapy at the discretion of the local investigator, or must have refused standard intensive chemotherapy
- Cohort I, Ph-negative Patients Only: Patients must not be candidates for allogeneic hematopoietic stem cell transplant; NOTE: Subjects up to age 70 years who are considered fit for allogeneic hematopoietic stem cell transplant, should be considered for enrollment on E1910, in order to avoid competing with that study; if a patient is considered unfit for intensive chemotherapy at the time of initial diagnosis, but subsequently achieves a complete remission (CR), then it will be left to the treating physician's discretion to consider hematopoietic stem cell transplant (HSCT)
- Cohort I, Ph-negative Patients Only: Patients must have complete history and physical examination within 28 days prior to registration
- Cohort I, Ph-negative Patients Only: Patients must have a Zubrod performance status of 0-2
- Cohort I, Ph-negative Patients Only: Patients must have serum creatinine =\< 1.5 mg/dl within 14 days prior to registration
- Cohort I, Ph-negative Patients Only: Patients must have aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 3.0 x institutional upper limit of normal (IULN) within 14 days prior to registration
- Cohort I, Ph-negative Patients Only: Patients must have total bilirubin =\< 2.0 x IULN within 14 days prior to registration
- Cohort I, Ph-negative Patients Only: Patients must have alkaline phosphatase =\< 2.5 x IULN within 14 days prior to registration
- Cohort I, Ph-negative Patients Only: Patients must not have systemic fungal, bacterial, viral or other infection that is not controlled (defined as exhibiting ongoing signs/symptoms related to the infection and without improvement, despite appropriate antibiotics or other treatment)
- Cohort I, Ph-negative Patients Only: Patients must not have Common Terminology Criteria for Adverse Events (CTCAE) \>= grade 2 neuropathy (cranial, motor or sensory) within 14 days prior to registration
- Cohort I, Ph-negative Patients Only: Patients known to be positive for HIV (the human immunodeficiency virus) may be eligible, providing they meet the following additional criteria within 28 days prior to registration:
- No history of acquired immune deficiency syndrome (AIDS)-defining conditions
- CD4 cells \> 350 cells/mm\^3
- If on antiretroviral agents, must not include zidovudine or stavudine
- Viral load =\< 50 copies HIV messenger ribonucleic acid (mRNA)/mm\^3 if on combination antiretroviral therapy (cART) or =\< 25,000 copies HIV mRNA/mm\^3 if not on cART
- Highly active antiretroviral therapy (HAART) regimens are acceptable providing they have only weak P450A4 interactions
- Cohort I, Ph-negative Patients Only: Patients must not have any known autoimmune disease
- Cohort I, Ph-negative Patients Only: Patients must not have testicular involvement; if clinical or ultrasound findings are equivocal, biopsy must be performed; all tests for establishing testicular involvement must be completed within 14 days prior to registration
- Cohort I, Ph-negative Patients Only: Patients with evidence of extramedullary disease at diagnosis will have computed tomography (CT) scan or magnetic resonance imaging (MRI) of the chest, abdomen and pelvis to obtain baseline values within 28 days prior to registration
- Cohort I, Ph-negative Patients Only: No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years
- Cohort I, Ph-negative Patients Only: Patients must have the following tests within 28 days prior to registration to obtain baseline measurements:
- Prothrombin time (PT)/partial thromboplastin time (PTT)/international normalized ratio (INR)/fibrinogen (all patients)
- Cohort 1, Ph- Patients Only: Neurologic assessment
- Cohort 2, Ph+ and Ph-like DSMKF Patients Only: Patients must not have active pericardial effusion, ascites or pleural effusion of any grade based on chest x-ray and echocardiogram within 28 days prior to registration; exception: if the effusion is suspected to be related to the leukemia, the patient may have pericardial effusion =\< grade 2 or pleural effusion =\< grade 1
- Cohort 2, Ph+ and Ph-like DSMKF Patients Only: Patients must have ejection fraction \>= 45% based on echocardiogram performed within 28 days prior to registration
- Cohort 2, Ph+ and Ph-like DSMKF Patients Only: Patients must have QTcF (by Fridericia calculation) \< 480/msec based on electrocardiogram (EKG) performed within 28 days prior to registration
- Cohort 2, Ph+ and Ph-like DSMKF Patients Only: Patients must not be receiving any proton pump inhibitors at the time of registration
- Pretreatment cytogenetics must be performed on all patients; collection of pretreatment specimens must be completed within 28 days prior to registration to S1318; specimens must be submitted to the site's preferred CLIA-approved cytogenetics laboratory; BCR-ABL status must be verified in Ph-positive patients by FISH, cytogenetics, and/or PCR prior to enrollment; if a patient is Ph-positive, PCR for both p190 and p210 must be sent
- Patients must be offered participation in specimen submission for future research; with patient's consent, specimens must be submitted as outlined
- Cohort 1, Ph-negative Patients Only: Patients must have specimens submitted for blinatumomab immunogenicity assessment; collection of pretreatment specimens must be completed within 28 days prior to registration to S1318; specimens must be submitted to LabConnect
- Cohort 2, Ph-positive and Ph-like DSMKF Patients Only: Patients must agree to have specimens submitted for blinatumomab immunogenicity testing if subsequently moved to a blinatumomab containing treatment regimen on protocol
- Patients or their legally authorized representative must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
- As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
- Registration Step 2 - Post-Remission Therapy:
- Cohort 1, Ph-negative Patients Only: Patients must have achieved CR or CRi within 2 cycles of induction/re-induction with blinatumomab
- NOTE: day 1 of post-remission = day 43 of the preceding cycle (+/- 3 days)
- Cohort 2, Ph-positive and Ph-like DSMKF Patients Only: Newly diagnosed Ph+, newly-diagnosed Ph-like DSMKF, and relapsed/refractory Ph+ patients without prior dasatinib or other 2nd or 3rd generation TKI therapy, must have achieved CR or CRi within 1 cycle of induction with dasatinib/prednisone, or within 2 cycles of re-induction with blinatumomab; relapsed/refractory Ph+ or Ph-like DSMKF patients with prior dasatinib or other 2nd or 3rd generation TKI therapy must have achieved CR or CRi within 2 cycles of re-induction therapy with blinatumomab
- NOTE: day 1 of post-remission = day 85 of the preceding induction cycle (+/- 3 days), or day 43 of the preceding re-induction cycle (+/- 3 days) as applicable
- Serum creatinine =\< 1.5 mg/dl within 14 days prior to registration
- AST and ALT =\< 3.0 x institutional upper limit of normal (IULN) within 14 days prior to registration
- Total bilirubin =\< 2.0 x IULN within 14 days prior to registration
- Absolute neutrophil count (ANC) \>= 750/mcL within 28 days prior to registration
- Platelets \>= 50,000/mcL within 28 days prior to registration
- Patients must be registered to Step 2 within 28 days after count recovery; (Note: there is no maximum allotted time period for count recovery, providing patient remains in CR or CRi)
- All non-hematologic treatment related toxicities that are deemed clinically significant by the treating investigator must have resolved to =\< grade 2
- Registration Step 3 - Maintenance: Patients must have documented CR or CRi within 28 days prior to registration; note that bone marrow examination is only required if there are clinical signs/symptoms of progression; if progression is a concern due to the length of the time for count recovery, a bone marrow examination is recommended
- Registration Step 3 - Maintenance: Patients must have serum creatinine =\< 1.5 mg/dl within 14 days prior to registration
- Registration Step 3 - Maintenance: Patients must have AST and ALT =\< 3.0 x institutional upper limit of normal (IULN) within 14 days prior to registration
- Registration Step 3 - Maintenance: Patients must have total bilirubin \< 2.0 x institutional upper limit of normal (IULN) within 14 days prior to registration
- Registration Step 3 - Maintenance: Patients must have adequate marrow function as evidenced by ANC \>= 750/mcL within 28 days prior to registration
- Registration Step 3 - Maintenance: Patients must have adequate marrow function as evidenced by platelets \>= 75,000/mcL within 28 days prior to registration
- Registration Step 3 - Maintenance: All non-hematologic treatment related toxicities that are deemed clinically significant by the treating investigator must have resolved to =\< grade 2
Age in the registry: 65 years to - · Sex: All · Does not accept healthy volunteers
Sites (195)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hickman Cancer Center Coordinator of this site? Confirm its status | Adrian | United States | Unknown status |
| University of New Mexico Cancer Center Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| McFarland Clinic - Ames Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| University of Michigan Rogel Cancer Center Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Northside Hospital Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Augusta University Medical Center Coordinator of this site? Confirm its status | Augusta | United States | Unknown status |
| Rush-Copley Medical Center Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| University of Maryland/Greenebaum Cancer Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Bronson Battle Creek Coordinator of this site? Confirm its status | Battle Creek | United States | Unknown status |
| Nebraska Medicine-Bellevue Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| Sanford Joe Lueken Cancer Center Coordinator of this site? Confirm its status | Bemidji | United States | Unknown status |
| University of Alabama at Birmingham Cancer Center Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Sanford Bismarck Medical Center Coordinator of this site? Confirm its status | Bismarck | United States | Unknown status |
| Illinois CancerCare-Bloomington Coordinator of this site? Confirm its status | Bloomington | United States | Unknown status |
| OSF Saint Joseph Medical Center Coordinator of this site? Confirm its status | Bloomington | United States | Unknown status |
| Prisma Health Cancer Institute - Spartanburg Coordinator of this site? Confirm its status | Boiling Springs | United States | Unknown status |
| Central Care Cancer Center - Bolivar Coordinator of this site? Confirm its status | Bolivar | United States | Unknown status |
| Parkland Health Center-Bonne Terre Coordinator of this site? Confirm its status | Bonne Terre | United States | Unknown status |
| McFarland Clinic - Boone Coordinator of this site? Confirm its status | Boone | United States | Unknown status |
| Cox Cancer Center Branson Coordinator of this site? Confirm its status | Branson | United States | Unknown status |
| Roswell Park Cancer Institute Coordinator of this site? Confirm its status | Buffalo | United States | Unknown status |
| Illinois CancerCare-Canton Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Saint Francis Medical Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Mercy Cancer Center - Cape Girardeau Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Memorial Hospital of Carbondale Coordinator of this site? Confirm its status | Carbondale | United States | Unknown status |
| Illinois CancerCare-Carthage Coordinator of this site? Confirm its status | Carthage | United States | Unknown status |
| Miami Valley Hospital South Coordinator of this site? Confirm its status | Centerville | United States | Unknown status |
| Centralia Oncology Clinic Coordinator of this site? Confirm its status | Centralia | United States | Unknown status |
| Cancer Center of Kansas - Chanute Coordinator of this site? Confirm its status | Chanute | United States | Unknown status |
| University of Illinois Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of Chicago Comprehensive Cancer Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Oncology Hematology Care Inc-Eden Park Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Oncology Hematology Care Inc-Mercy West Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Oncology Hematology Care Inc-Blue Ash Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Oncology Hematology Care Inc-Anderson Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Oncology Hematology Care Inc-Kenwood Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Cleveland Clinic Foundation Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Case Western Reserve University Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Ohio State University Comprehensive Cancer Center Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Oncology Hematology Care Inc-Crestview Coordinator of this site? Confirm its status | Crestview Hills | United States | Unknown status |
| Baylor University Medical Center Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Carle at The Riverfront Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| Good Samaritan Hospital - Dayton Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Miami Valley Hospital Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Miami Valley Hospital North Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Cancer Care Specialists of Illinois - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Decatur Memorial Hospital Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Wayne State University/Karmanos Cancer Institute Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| Cancer Center of Kansas - Dodge City Coordinator of this site? Confirm its status | Dodge City | United States | Unknown status |
| City of Hope Comprehensive Cancer Center Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
| Duke University Medical Center Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| Prisma Health Cancer Institute - Easley Coordinator of this site? Confirm its status | Easley | United States | Unknown status |
| Crossroads Cancer Center Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Carle Physician Group-Effingham Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Cancer Center of Kansas - El Dorado Coordinator of this site? Confirm its status | El Dorado | United States | Unknown status |
| Illinois CancerCare-Eureka Coordinator of this site? Confirm its status | Eureka | United States | Unknown status |
| Oncology Hematology Care Inc-Healthplex Coordinator of this site? Confirm its status | Fairfield | United States | Unknown status |
| Sanford Broadway Medical Center Coordinator of this site? Confirm its status | Fargo | United States | Unknown status |
| Sanford Roger Maris Cancer Center Coordinator of this site? Confirm its status | Fargo | United States | Unknown status |
| Weisberg Cancer Treatment Center Coordinator of this site? Confirm its status | Farmington Hills | United States | Unknown status |
| Corewell Health Farmington Hills Hospital Coordinator of this site? Confirm its status | Farmington Hills | United States | Unknown status |
| Blanchard Valley Hospital Coordinator of this site? Confirm its status | Findlay | United States | Unknown status |
| McFarland Clinic - Trinity Cancer Center Coordinator of this site? Confirm its status | Fort Dodge | United States | Unknown status |
| Cancer Center of Kansas - Fort Scott Coordinator of this site? Confirm its status | Fort Scott | United States | Unknown status |
| Atrium Medical Center-Middletown Regional Hospital Coordinator of this site? Confirm its status | Franklin | United States | Unknown status |
| Western Illinois Cancer Treatment Center Coordinator of this site? Confirm its status | Galesburg | United States | Unknown status |
| Illinois CancerCare-Galesburg Coordinator of this site? Confirm its status | Galesburg | United States | Unknown status |
| Trinity Health Grand Rapids Hospital Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Saint Vincent Hospital Cancer Center at Saint Mary's Coordinator of this site? Confirm its status | Green Bay | United States | Unknown status |
| Saint Vincent Hospital Cancer Center Green Bay Coordinator of this site? Confirm its status | Green Bay | United States | Unknown status |
| Wayne Hospital Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Prisma Health Cancer Institute - Eastside Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Greenville Health System Cancer Institute-Andrews Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Prisma Health Greenville Memorial Hospital Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Prisma Health Cancer Institute - Faris Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Prisma Health Cancer Institute - Butternut Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Prisma Health Cancer Institute - Greer Coordinator of this site? Confirm its status | Greer | United States | Unknown status |
| William Beaumont Hospital-Grosse Pointe Coordinator of this site? Confirm its status | Grosse Pointe | United States | Unknown status |
| Cancer Center of Kansas-Independence Coordinator of this site? Confirm its status | Independence | United States | Unknown status |
| Franciscan Health Indianapolis Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| University of Mississippi Medical Center Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| McFarland Clinic - Jefferson Coordinator of this site? Confirm its status | Jefferson | United States | Unknown status |
| MU Health Care Goldschmidt Cancer Center Coordinator of this site? Confirm its status | Jefferson City | United States | Unknown status |
| Mercy Hospital Joplin Coordinator of this site? Confirm its status | Joplin | United States | Unknown status |
| Freeman Health System Coordinator of this site? Confirm its status | Joplin | United States | Unknown status |
| West Michigan Cancer Center Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| Beacon Kalamazoo Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| Bronson Methodist Hospital Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| University of Kansas Cancer Center Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| ECU Health Oncology Kenansville Coordinator of this site? Confirm its status | Kenansville | United States | Unknown status |
| Kettering Medical Center Coordinator of this site? Confirm its status | Kettering | United States | Unknown status |
| Illinois CancerCare-Kewanee Clinic Coordinator of this site? Confirm its status | Kewanee | United States | Unknown status |
| Cancer Center of Kansas-Kingman Coordinator of this site? Confirm its status | Kingman | United States | Unknown status |
| ECU Health Oncology Kinston Coordinator of this site? Confirm its status | Kinston | United States | Unknown status |
| UC San Diego Moores Cancer Center Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| Northwell Health/Center for Advanced Medicine Coordinator of this site? Confirm its status | Lake Success | United States | Unknown status |
| Lawrence Memorial Hospital Coordinator of this site? Confirm its status | Lawrence | United States | Unknown status |
| Cancer Center of Kansas-Liberal Coordinator of this site? Confirm its status | Liberal | United States | Unknown status |
| John L McClellan Memorial Veterans Hospital Coordinator of this site? Confirm its status | Little Rock | United States | Unknown status |
| Loma Linda University Medical Center Coordinator of this site? Confirm its status | Loma Linda | United States | Unknown status |
| USC / Norris Comprehensive Cancer Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Los Angeles General Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Illinois CancerCare-Macomb Coordinator of this site? Confirm its status | Macomb | United States | Unknown status |
| North Shore University Hospital Coordinator of this site? Confirm its status | Manhasset | United States | Unknown status |
| McFarland Clinic - Marshalltown Coordinator of this site? Confirm its status | Marshalltown | United States | Unknown status |
| Carle Physician Group-Mattoon/Charleston Coordinator of this site? Confirm its status | Mattoon | United States | Unknown status |
| Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Coordinator of this site? Confirm its status | Maumee | United States | Unknown status |
| Toledo Clinic Cancer Centers-Maumee Coordinator of this site? Confirm its status | Maumee | United States | Unknown status |
| Cancer Center of Kansas - McPherson Coordinator of this site? Confirm its status | McPherson | United States | Unknown status |
| Franciscan Saint Anthony Health-Michigan City Coordinator of this site? Confirm its status | Michigan City | United States | Unknown status |
| Woodland Cancer Care Center Coordinator of this site? Confirm its status | Michigan City | United States | Unknown status |
| Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Toledo Clinic Cancer Centers-Monroe Coordinator of this site? Confirm its status | Monroe | United States | Unknown status |
| SSM Health Good Samaritan Coordinator of this site? Confirm its status | Mount Vernon | United States | Unknown status |
| Trinity Health Muskegon Hospital Coordinator of this site? Confirm its status | Muskegon | United States | Unknown status |
| Smilow Cancer Center/Yale-New Haven Hospital Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Yale University Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Long Island Jewish Medical Center Coordinator of this site? Confirm its status | New Hyde Park | United States | Unknown status |
| UC Comprehensive Cancer Center at Silver Cross Coordinator of this site? Confirm its status | New Lenox | United States | Unknown status |
| USC Norris Oncology/Hematology-Newport Beach Coordinator of this site? Confirm its status | Newport Beach | United States | Unknown status |
| Cancer Center of Kansas - Newton Coordinator of this site? Confirm its status | Newton | United States | Unknown status |
| Corewell Health Lakeland Hospitals - Niles Hospital Coordinator of this site? Confirm its status | Niles | United States | Unknown status |
| Cancer Care Center of O'Fallon Coordinator of this site? Confirm its status | O'Fallon | United States | Unknown status |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Nebraska Medicine-Village Pointe Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| University of Nebraska Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| UC Irvine Health- Chao Family Comprehensive Cancer Center Coordinator of this site? Confirm its status | Orange | United States | Unknown status |
| Saint Charles Hospital Coordinator of this site? Confirm its status | Oregon | United States | Unknown status |
| Orlando Health Cancer Institute Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Illinois CancerCare-Ottawa Clinic Coordinator of this site? Confirm its status | Ottawa | United States | Unknown status |
| Radiation Oncology of Northern Illinois Coordinator of this site? Confirm its status | Ottawa | United States | Unknown status |
| Cancer Center of Kansas - Parsons Coordinator of this site? Confirm its status | Parsons | United States | Unknown status |
| Keck Medical Center of USC Pasadena Coordinator of this site? Confirm its status | Pasadena | United States | Unknown status |
| OSF Saint Francis Radiation Oncology at Pekin Coordinator of this site? Confirm its status | Pekin | United States | Unknown status |
| Illinois CancerCare-Pekin Coordinator of this site? Confirm its status | Pekin | United States | Unknown status |
| OSF Saint Francis Medical Center Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| OSF Saint Francis Radiation Oncology at Peoria Cancer Center Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Methodist Medical Center of Illinois Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Illinois CancerCare-Peoria Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Illinois CancerCare-Peru Coordinator of this site? Confirm its status | Peru | United States | Unknown status |
| Valley Radiation Oncology Coordinator of this site? Confirm its status | Peru | United States | Unknown status |
| Thomas Jefferson University Hospital Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| University of Pennsylvania/Abramson Cancer Center Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Providence Portland Medical Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Providence Saint Vincent Medical Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Cancer Center of Kansas - Pratt Coordinator of this site? Confirm its status | Pratt | United States | Unknown status |
| Illinois CancerCare-Princeton Coordinator of this site? Confirm its status | Princeton | United States | Unknown status |
| Corewell Health Reed City Hospital Coordinator of this site? Confirm its status | Reed City | United States | Unknown status |
| ECU Health Oncology Richlands Coordinator of this site? Confirm its status | Richlands | United States | Unknown status |
| Reid Health Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| University of Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Mercy Clinic-Rolla-Cancer and Hematology Coordinator of this site? Confirm its status | Rolla | United States | Unknown status |
| Phelps Health Delbert Day Cancer Institute Coordinator of this site? Confirm its status | Rolla | United States | Unknown status |
| Corewell Health William Beaumont University Hospital Coordinator of this site? Confirm its status | Royal Oak | United States | Unknown status |
| Sainte Genevieve County Memorial Hospital Coordinator of this site? Confirm its status | Sainte Genevieve | United States | Unknown status |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Coordinator of this site? Confirm its status | Saint Joseph | United States | Unknown status |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital Coordinator of this site? Confirm its status | Saint Joseph | United States | Unknown status |
| Cancer Center of Kansas - Salina Coordinator of this site? Confirm its status | Salina | United States | Unknown status |
| Prisma Health Cancer Institute - Seneca Coordinator of this site? Confirm its status | Seneca | United States | Unknown status |
| LSU Health Sciences Center at Shreveport Coordinator of this site? Confirm its status | Shreveport | United States | Unknown status |
| Siouxland Regional Cancer Center Coordinator of this site? Confirm its status | Sioux City | United States | Unknown status |
| Springfield Clinic Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Mercy Hospital Springfield Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Memorial Hospital Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Regional Cancer Center Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Regional Medical Center Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Southern Illinois University School of Medicine Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| CoxHealth South Hospital Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Central Illinois Hematology Oncology Center Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Mercy Hospital Saint Louis Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Missouri Baptist Medical Center Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Mercy Infusion Center - Chippewa Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Missouri Baptist Sullivan Hospital Coordinator of this site? Confirm its status | Sullivan | United States | Unknown status |
| Toledo Clinic Cancer Centers-Toledo Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| Mercy Health - Saint Anne Hospital Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| Munson Medical Center Coordinator of this site? Confirm its status | Traverse City | United States | Unknown status |
| Corewell Health Beaumont Troy Hospital Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| Upper Valley Medical Center Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| Banner University Medical Center - Tucson Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| University of Arizona Cancer Center-North Campus Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| Carle Cancer Center Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| The Carle Foundation Hospital Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| Cancer Center of Kansas - Wellington Coordinator of this site? Confirm its status | Wellington | United States | Unknown status |
| University of Kansas Hospital-Westwood Cancer Center Coordinator of this site? Confirm its status | Westwood | United States | Unknown status |
| Wesley Medical Center Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Ascension Via Christi Hospitals Wichita Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Associates In Womens Health Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Cancer Center of Kansas-Wichita Medical Arts Tower Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Cancer Center of Kansas - Wichita Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Cancer Center of Kansas - Winfield Coordinator of this site? Confirm its status | Winfield | United States | Unknown status |
| Wake Forest University Health Sciences Coordinator of this site? Confirm its status | Winston-Salem | United States | Unknown status |
| Wright-Patterson Medical Center Coordinator of this site? Confirm its status | Wright-Patterson Air Force Base | United States | Unknown status |
| Rush-Copley Healthcare Center Coordinator of this site? Confirm its status | Yorkville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.