NCT02154568Completed
Study of Airflow in the Lungs Using Helium MRI
Flow Quantification in the Human Airways Using Hyperpolarized Helium 3 MRI
Source: ClinicalTrials.gov · Last updated 17 Mar 2026
Brief summary (registry, in English)
Computer simulations are being developed to predict air flow abnormalities in the airways of patients with lung disease. The purpose of this study is to obtain actual gas flow measurements in the lungs of healthy patients and patients with lung disease and use these measurements to validate the computer models.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 24 (actual)
- First submitted
- 30 May 2014
- Start date
- 7 Nov 2013
- Primary completion date
- 26 Feb 2026
- Lead sponsor
- University of Virginia
- Diseases
- COPD
- NCT number
- NCT02154568
What you commit to
- Study type: Interventional
- Participants enrolled: 24
- From 7 Nov 2013 to the primary completion date, 26 Feb 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pregnancy, by report of subject. Clinically in the Department of radiology at UVA, self report is used when screening patients for MR scans as well as CT scans and fluoroscopy studies. If the subject reports there is any chance of their being pregnant a urine pregnancy test will be performed prior to any imaging.
Other illness
- Any condition for which a MRI procedure is contraindicated.
Other
- Presence of any non-MRI compatible metallic material in the body, such as pacemakers, metallic clips, etc.
- Likelihood of claustrophobia
- Chest circumference greater than that of the helium MR coil.
Who the study is looking for
- Healthy subjects:
- Normal PFT values: FEV1 \> 90% predicted; and Forced vital capacity (FVC) \> 90% predicted
- Normal chest x-ray (CXR)
- Medical history: No active pulmonary symptoms (cough, shortness of breath, sputum); Negative history of pulmonary disease; Negative smoking history (never smoked)
- Pulmonary Disease Subjects:
- PFT values: FEV1/FVC \< 70% (indicative of obstruction); and 30% \< FEV1 \< 50% predicted
- CXR normal except hyperinflation
- Symptoms - chronic shortness of breath
- All test subjects, healthy and with COPD should have similar physical anthropometric characteristics:
- Similar age with age difference less than 3 years
- Similar height (within 3-4 inches)
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Virginia Health System Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
| Snyder Translation Fontaine Research Center 480 Ray C. Hunt Drive Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.