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NCT02220309Completed

Stanford RAD-AT Study (Research on Anxiety and Depression - Anhedonia Treatment)

Neural Dimensions of Threat Reactivity and Regulation for Understanding Anxiety

Source: ClinicalTrials.gov · Last updated 5 Jan 2026

Brief summary (registry, in English)

This research study is aimed at understanding behaviors and brain circuits that relate to anxiety and depression. Our goal is to learn which circuits of the brain are involved in anxiety and how these circuits might affect daily functioning. This study has recently added an additional treatment component: participants undergo a 12 week course of either Pramipexole medication or rTMS therapy (explained below). The ultimate goal of the study is to offer participants experiencing anxiety and depression a treatment that is alternative to ones that have failed them in the past, and to apply the knowledge we gain from investigating the brain circuits involved in anxiety and depression to help personalize treatments. We invite anyone who has recently experienced any symptoms of anxiety and/or depression to participate (no diagnosis is required to participate).

Status (registry)
Completed
Study type
Observational
Enrollment
167 (actual)
First submitted
13 Aug 2014
Start date
11 Aug 2013
Primary completion date
18 Dec 2024
Lead sponsor
Stanford University
NCT number
NCT02220309

What you commit to

  • Study type: Observational
  • Participants enrolled: 167
  • From 11 Aug 2013 to the primary completion date, 18 Dec 2024
  • 3 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Specific psychiatric medications (case-by-case basis)
  • A diagnosis of Bipolar 1 Disorder, Schizophrenia, or Obsessive Compulsive Disorder
  • Any of the following medical conditions: Parkinson's disease; liver or kidney disease; history of epilepsy or seizures; history of cardiovascular disorders (specifically orthostatic hypotension)

Who the study is looking for

  • Recent experiences of anxiety and/or depression
  • Ages 18-65

Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (3)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Gronowski Center-5150 El Camino Real
Coordinator of this site? Confirm its status
Los AltosUnited StatesUnknown status
VAPAHCS/Palo Alto MIRECC-3801 Miranda Avenue
Coordinator of this site? Confirm its status
Palo AltoUnited StatesUnknown status
Stanford University Department of Psychiatry
Coordinator of this site? Confirm its status
StanfordUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.