NCT02220309Completed
Stanford RAD-AT Study (Research on Anxiety and Depression - Anhedonia Treatment)
Neural Dimensions of Threat Reactivity and Regulation for Understanding Anxiety
Source: ClinicalTrials.gov · Last updated 5 Jan 2026
Brief summary (registry, in English)
This research study is aimed at understanding behaviors and brain circuits that relate to anxiety and depression. Our goal is to learn which circuits of the brain are involved in anxiety and how these circuits might affect daily functioning. This study has recently added an additional treatment component: participants undergo a 12 week course of either Pramipexole medication or rTMS therapy (explained below). The ultimate goal of the study is to offer participants experiencing anxiety and depression a treatment that is alternative to ones that have failed them in the past, and to apply the knowledge we gain from investigating the brain circuits involved in anxiety and depression to help personalize treatments. We invite anyone who has recently experienced any symptoms of anxiety and/or depression to participate (no diagnosis is required to participate).
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 167 (actual)
- First submitted
- 13 Aug 2014
- Start date
- 11 Aug 2013
- Primary completion date
- 18 Dec 2024
- Lead sponsor
- Stanford University
- Diseases
- Bipolar disorder
- NCT number
- NCT02220309
What you commit to
- Study type: Observational
- Participants enrolled: 167
- From 11 Aug 2013 to the primary completion date, 18 Dec 2024
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Specific psychiatric medications (case-by-case basis)
- A diagnosis of Bipolar 1 Disorder, Schizophrenia, or Obsessive Compulsive Disorder
- Any of the following medical conditions: Parkinson's disease; liver or kidney disease; history of epilepsy or seizures; history of cardiovascular disorders (specifically orthostatic hypotension)
Who the study is looking for
- Recent experiences of anxiety and/or depression
- Ages 18-65
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Gronowski Center-5150 El Camino Real Coordinator of this site? Confirm its status | Los Altos | United States | Unknown status |
| VAPAHCS/Palo Alto MIRECC-3801 Miranda Avenue Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| Stanford University Department of Psychiatry Coordinator of this site? Confirm its status | Stanford | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.