A Trial of Aspirin on Recurrence and Survival in Colon Cancer Patients

Prior treatment

• Patients currently taking oral anti-coagulants or use of LMWH
• Patients currently taking acetylsalicylic acid for any reason
• Patients currently taking high dose systemic glucocorticoids.(≥ 30 mg predniso(lo)n)

Other illness

• Patients with rectal cancer (defined as tumour within 15 cm from the anal verge)
• Patients with a history of bleeding disorders or active gastric or duodenal ulcers
• Patients with (suspected) (non-) polyposis syndrome (FAP/AFAP, MAP, Lynch syndrome)
• Patients with \>100 polyps of the colon or a known hereditary syndrome of the colon in a first degree family member
• Allergy or intolerance to salicylates.
• Patients with a history of other malignancies in the last 5 years, except for SCC or CIN.
• Presence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial

• Age ≥45 years
• Patients must have TNM stage that is one of the following: pT3-4; N0-2 and M0, or pT1-2 and N1-2 (UICC stage II and III) (in case of \>1 tumour: largest tumour is stage II or III)
• Patients must have completed surgical resection (R0) (both laparoscopic and open surgery) within 12 weeks of randomisation