NCT02301663Recruiting
Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease
Source: ClinicalTrials.gov · Last updated 1 Sept 2023 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women. There are an estimated 2-3 million women in the US with MCD and about 100,000 new cases annually. Recent data from our research group suggests that coronary microvascular disease impairs the way the heart relaxes. This pilot study will attempt to exacerbate this phenotype in an effort to better understand the pathophysiology of the disease. The investigators will recruit 30 volunteers total (10 healthy calibration subjects, 10 women with microvascular disease, and 10 age-match women for the group with microvascular disease). Subjects will undergo a series of "stress" maneuvers in conjunction with advanced cardiac magnetic resonance imaging.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 22 Nov 2014
- Start date
- Nov 2014
- Primary completion date
- Dec 2030
- Lead sponsor
- Cedars-Sinai Medical Center
- Diseases
- Coronary artery disease
- NCT number
- NCT02301663
What you commit to
- Study type: Interventional
- Planned participants: 30
- From Nov 2014 to the primary completion date, Dec 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contra-indication to CMRI testing, including claustrophobia and metallic implants
Other illness
- History of cardiovascular, pulmonary, or neurological disease
- Hypertension (sitting blood pressure \>140/90 mmHg, with measurements recorded on at least 2 occasions)
- Diabetes
- Allergy to animal dander.
Other
- Unable to give informed consent;
- Adherence or retention issues;
- Women who are pregnant.
Who the study is looking for
- Fully understanding and willing to undergo study procedures
- Male or Female greater than or equal to 18 years of age
- Understanding and willing to sign consent form.
Age in the registry: 18 years to 60 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cedars-Sinai Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.