NCT02347995Completed
Resistive Training Combined With Nutritional Therapy After Stroke
Source: ClinicalTrials.gov · Last updated 17 Sept 2026
Brief summary (registry, in English)
Stroke survivors experience severe muscle wasting during the chronic phase of recovery, with implications for strength, function and general health. Although resistive exercise training effectively combats this problem, it is unknown whether sub-optimal protein intake limits the observed gains in skeletal muscle growth. Skeletal muscle adaptations may occur when resistive training (RT) is combined with nutritional therapy in the form of post- exercise protein consumption. This study would be the first to directly compare RT+protein supplementation to RT+placebo (same calories as protein supplement) in those with chronic hemiparesis caused by stroke, providing evidence-based rationale for combination therapy in the clinical care of this population.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 93 (actual)
- First submitted
- 8 Jan 2015
- Start date
- 24 Aug 2015
- Primary completion date
- 31 Aug 2026
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Stroke
- NCT number
- NCT02347995
What you commit to
- Study type: Interventional
- Participants enrolled: 93
- From 24 Aug 2015 to the primary completion date, 31 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Cardiac history of: a) unstable angina, b) recent (less than 3 months prior to study entry) myocardial infarction, congestive heart failure (NYHA category II-IV); c) hemodynamically significant valvular dysfunction
Other illness
- Neurological history of: a) dementia by clinical evaluation, b) severe receptive or global aphasia, which confounds testing and training, operationally defined as unable to follow 2 point commands, c) untreated major depression by clinical interview
- Any medical condition that, in the opinion of the Investigator, might interfere with the subject's participation in the study, poses any added risk for the subject, or confounds the assessment of the subject
Lab values
- Medical History: a) recent hospitalization (less than 3 months prior to study entry) for severe medical disease, b) orthopedic or chronic pain condition restricting exercise, c) pulmonary or renal failure, d) active cancer, e) untreated poorly controlled hypertension measured on at least 2 occasions (greater than 190/100) f) untreated and / or poorly controlled diabetes with fasting blood glucose of greater than 170 and hemoglobin A1C (HbA1C) greater than 10.0, grams (g) medications: oral steroids, h) currently pregnant
Other
- Regular structured resistive exercise (\>2x/week)
- Alcohol consumption \>3 ounces (oz.) liquor, 3 x 4oz. glasses of wine, or 3 x 12oz beers/day, by self report
Who the study is looking for
- Stroke \> 3 months prior
- Completion of all regular post-stroke physical therapy
- Adequate language and neurocognitive function to participate in testing and training and to provide informed consent
- Able to walk 10 meters without human assistance
Age in the registry: 30 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.