Perioperative Chemotherapy With Bevacizumab for Colorectal Carcinomatosis

Other illness

• evidence of extra-abdominal disease or extensive liver metastasis
• peritoneal cancer index \> 25
• active bacterial, viral or fungal infection
• active gastro-duodenal ulcer
• parenchymal liver disease (any stage cirrhosis)
• uncontrolled diabetes mellitus
• severe obstructive or restrictive respiratory insufficiency
• psychiatric pathology capable of affecting comprehension and judgment faculty
• Known allergy to oxaliplatin

Other

• No written informed consent
• tumour in the presence of obstruction

• biopsy proven adenocarcinoma of the colon or rectum and synchronous or metachronous peritoneal carcinomatosis.
• absence of systemic disease, with the exception of small, superficial liver metastases, requiring only minor surgery.
• resectable disease at staging, during laparoscopic evaluation and during exploration for cytoreductive surgery and intraperitoneal chemotherapy.
• complete macroscopic cytoreduction at the time of surgery (CC-0/1)
• good general health status (Karnofsky index \> 70%)
• expected life expectancy more than 6 months
• no other malignancy than disease under study
• serum creatinine \< 1.5 mg/dl or a calculated GFR ≥ 60 mL/min/1.73 m
• serum total bilirubin \< 1.5 mg/dl
• platelet count \> 100,000/ml
• hemoglobin \> 9g/dl
• neutrophil granulocytes \> 1,500/ml
• International Normalized Ration (INR) 2 or \< 2
• Absence of alcohol and/or drug abuse
• No inclusion in other clinical trials interfering with the study protocol
• No concurrent chronic systemic immune therapy, chemotherapy, or hormone therapy not indicated in the study protocol
• Absence of heart failure (NYHA 2 or \> 2) or significant coronary artery disease
• No pregnancy or breast feeding
• Adequate contraception in fertile patients