NCT02411773RecruitingPhase 1
Sympatholysis in Chronic Kidney Disease
Functional Sympatholysis and Exercise Intolerance in Chronic Kidney Disease
Source: ClinicalTrials.gov · Last updated 18 May 2026
Brief summary (registry, in English)
The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 110 (estimated)
- First submitted
- 3 Apr 2015
- Start date
- 11 Jun 2015
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Emory University
- Diseases
- Chronic kidney disease
- NCT number
- NCT02411773
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 110
- From 11 Jun 2015 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Ongoing drug or alcohol abuse
- Symptomatic heart disease determined by prior electrocardiogram, stress test, and/or history
- Treatment with central alpha agonists (clonidine)
- Current treatment with monoamine oxidase inhibitors (MAOIs)
Other illness
- Any serious systemic disease that might influence survival
- Uncontrolled hypertension with blood pressure (BP) greater than 170/100 mmHg
Lab values
- Severe CKD (estimated glomerular filtration rate (eGFR) \< 15 cc/minute)
- Metabolic alkalosis (serum bicarbonate \> 28 meq/L)
- Severe anemia with hemoglobin (Hbg) level \< 10 g/dL
- Clinical evidence of congestive heart failure or ejection fraction below 35%
Other
- Diabetic neuropathy
- Low blood pressure with BP less than 100/50 mmHg
- Pregnancy or plans to become pregnant
- Inability to exercise on a stationary bicycle
Who the study is looking for
- Veterans with Stages III and IV Chronic Kidney Disease (CKD)
- Kidney transplant recipients with varying degrees of kidney function
- Veterans 18-75 years old, without kidney disease, as study controls
- Exercise less than 20 minutes twice per week
- Willing and able to cooperate with the protocol
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Atlanta VA Medical Center Coordinator of this site? Confirm its status | Decatur | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.