NCT02421497Not yet recruiting
MRI Technical Development and Applications in Kidney Disease
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
Magnetic resonance imaging (MRI), as a non-invasive and non-contrast enhanced technique, has the potential to improve patient health care and management. The overall objective of proposed project is to: 1. develop, customize, and optimize anatomic and functional MRI methods, 2. explore the use of MRI methods to study CKD and evaluate post-transplant kidneys, and 3. investigate the potential of MRI in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction. In addition to direct studies of the kidney, brain MRI studies will also be performed to identify the cerebrovascular and cognitive effects of chronic renal function deficiency and medical treatment (e.g. hemodialysis and immunosuppression). The brain and kidneys have similar vascular bed, and both are susceptible to vascular injury, which provides the pathological basis for the widely recognized association of reduced renal function with prevalent cerebrovascular diseases (CVDs) and cognitive impairment (CI). The MRI methods in the brain will be applied to explore the origins for widely observed CVDs and prevalent cognitive impairment (CI) in kidney disease patients.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 180 (estimated)
- First submitted
- 15 Apr 2015
- Start date
- 30 Jun 2028
- Primary completion date
- 30 Jun 2029
- Lead sponsor
- University of Minnesota
- Diseases
- Chronic kidney disease
- NCT number
- NCT02421497
What you commit to
- Study type: Observational
- Planned participants: 180
- From 30 Jun 2028 to the primary completion date, 30 Jun 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Ferromagnetic implants
- Active chemical dependence, such as alcohol, narcotics or other drugs
- Dialysis dependent or renal transplant recipient at time of screening or baseline
- Severe CI unable to complete the Modified Mini-Mental State Examination \[3MSE\]
- Studies for Renal Transplantation
- Inclusion
Other illness
- History of shrapnel or shot gun injury
- Cardiac pacemakers
- Acute psychiatric illness that would impede cognitive testing
- Chronic obstructive pulmonary disease
- Not on dialysis due to allograft failure
- Chronic obstructive pulmonary disease
Lab values
- GFR \< 90 ml/min/1.73m2
- Exclusion
Age
- Age 45 years and older
- Age 45 years and older
- Exclusion
Other
- Any foreign metal objects in the body
- Defibrillator
- Neuronal stimulator
- Magnetic aneurysm clip
- Large tattoos on the abdomen or the brain and neck
- Hip replacement
- Too large to fit in the magnet (body mass index \>= 40, approx.)
- Severe claustrophobia
- Women with pregnancy
- For Specific Aim 2: Pilot Studies with Patients
- Studies for CKD
- Inclusion
- English- speaking as primary language.
- Able to complete an approximately 90 minute cognitive testing battery.
- Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so.
- Legally blind or unable to complete cognitive tests due to visual loss or deafness
- Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so.
Who the study is looking for
- 1\. Healthy Volunteer
Criteria the registry did not label
- For Specific Aim 1: MRI Technical Development Studies
Age in the registry: 18 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Center for Magnetic Resonance Research Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.