NCT02467231Active, not recruiting
Ovarian Reserve After Cancer: Longitudinal Effects
Ovarian Reserve After Cancer: Longitudinal Effects A Multicenter Prospective Cohort Study by the Oncofertility Consortium
Source: ClinicalTrials.gov · Last updated 28 Oct 2025
Brief summary (registry, in English)
Women of reproductive age who will receive treatment for cancer that includes chemotherapy may participate in a study measuring ovarian function over time. Eligible women are asked to complete a questionnaire, a menstrual diary, a brief physical examination, an ultrasound, and a blood test before, during and after cancer treatment.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 196 (actual)
- First submitted
- 22 Jul 2013
- Start date
- 1 Feb 2009
- Primary completion date
- 30 Apr 2028
- Lead sponsor
- University of Pennsylvania
- Diseases
- Ovarian cancer, Childhood cancers
- NCT number
- NCT02467231
What you commit to
- Study type: Observational
- Participants enrolled: 196
- From 1 Feb 2009 to the primary completion date, 30 Apr 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- lactation within the previous 1 month,
- previous treatment with chemotherapy or radiation therapy with the exception of radioactive iodine for thyroid cancer.
- previous diagnosis of an illness associated with premature ovarian failure (Turner's syndrome, Fragile X permutation carrier)
Other illness
- endocrine disorder associated with irregular menstrual cycles (Cushing's disease, Thyroid disease, hyper-prolactinemia, congenital adrenal hyperplasia).
- Additional exclusions for the unexposed population:
- a history of infertility, defined as at least 12 months of unprotected intercourse without conception
- polycystic ovary syndrome (PCOS)
Other
- positive pregnancy test at enrollment
Who the study is looking for
- Postmenarchal females to be treated with chemotherapy
- between the ages of 11-35 years,
- with a uterus and at least one ovary
- healthy postmenarchal females
- no prior or planned exposure to chemotherapy
- between the ages of 11-35,
- with a uterus and at least one ovary
- regular menstrual cycles (21-35 days)
Age in the registry: 11 years to 35 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pennsylvania, Reproductive Research Unit Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.