NCT02485730Active, not recruiting
Early Identification of Markers in Alzheimer's Families / ALFA
Cohort Study for Early Identification of Markers in Cognitively Healthy Family Members of Patients With Alzheimer's Disease
Source: ClinicalTrials.gov · Last updated 31 May 2025
Brief summary (registry, in English)
The ALFA study is a long term, prospective, observational study of AD patients' adult children aimed at studying and characterizing key physio-pathological features of the preclinical phase of AD.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 419 (actual)
- First submitted
- 10 Jun 2015
- Start date
- 25 Oct 2016
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
- Diseases
- Alzheimer disease
- NCT number
- NCT02485730
What you commit to
- Study type: Observational
- Participants enrolled: 419
- From 25 Oct 2016 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Cognitive impairment: to be included the participant must show no signs of objective cognitive impairment.
- Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the protocol.
- Family history of monogenic AD.
Other
- Illiteracy or functional illiteracy.
- Any contraindication to any test or procedure at the time of study inclusion.
- Not willing to undergo one or more of the tests and procedures described in the protocol at baseline.
Who the study is looking for
- Adult children of AD patient: First-degree descendant of an AD patient (following diagnosis as define in protocol).
- Age: 45 to 64 years old.
- Long-term commitment to the study: baseline and follow-up visits. Potential participants have to agree to undergo to all the procedures described in the protocol.
Age in the registry: 45 years to 64 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Barcelonabeta Brain Research Center Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
Related publications
- Air pollution is associated with sex-specific longitudinal changes in astrocytic and neuroinflammatory processes linked to cognitive decline in Alzheimer's disease at-risk individuals.Alzheimers Dement · 2026 · PMID 42872554
- Sex-specific early cognitive changes are linked to global and pathway-specific genetic risk for Alzheimer's disease in at-risk individuals.Biol Sex Differ · 2026 · PMID 41703636
- Red blood cell ω-3 status and longitudinal cognition in individuals at risk of Alzheimer disease.J Nutr · 2025 · PMID 41022152
This page is information, not medical advice. Discuss any trial with your doctor.