NCT02496468Recruiting
Pediatric Arm of DZL All Age Asthma Cohort
The All Age Asthma Cohort (ALLIANCE) of the German Center for Lung Research (DZL), Pediatric Arm
Source: ClinicalTrials.gov · Last updated 28 Aug 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Despite its common occurrence, still little is known about pathomechanisms determining different wheeze and asthma trajectories and phenotypes in children, and those beginning in adulthood. Therefore, deciphering underlying determinants for different childhood and adult asthma phenotypes is urgently needed to develop personalized treatment approaches targeting distinct underlying mechanisms. Thereby, secondary prevention early in the disease process can also be achieved. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma Allergy of the 'German Centre for Lung Research' (DZL).
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1500 (estimated)
- First submitted
- 3 Jul 2015
- Start date
- Jan 2013
- Primary completion date
- Dec 2027
- Lead sponsor
- LMU Klinikum
- Diseases
- Asthma
- NCT number
- NCT02496468
What you commit to
- Study type: Observational
- Planned participants: 1500
- From Jan 2013 to the primary completion date, Dec 2027
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- oxygen therapy after birth with a duration of more than 24 hours
- fever of at least 38.5°C during the last two weeks prior to the planned first visit
Other illness
- known inborn or perinatal pulmonary disease
- heart failure diagnosed after birth affecting pulmonary circulation
- major respiratory diseases such as e.g. interstitial lung disease
Other
- airway malformation
- ventilator support or mechanical ventilation after birth
- diagnoses of cystic fibrosis; primary ciliary dyskinesia
- any current non-atopic comorbidity
Who the study is looking for
- informed consent by parents (and by children if age \> 8 years)
- age 6 months to 18 years
- term delivery (≥ 37 weeks)
- active/passive understanding of German
- age 6 months - \< 6 years: preschool wheeze (more than two episodes of wheeze during 12 months prior to inclusion)
- age at least 6 years: doctor diagnosed asthma (according to current guidelines)
Age in the registry: 6 months to 18 years · Sex: All · Accepts healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Children's Hospital Cologne, Department of Paediatric Allergology and Pneumology Coordinator of this site? Confirm its status | Cologne | Germany | Recruiting |
| Medizinische Hochschule Hannover, Biomedical Research in Endstage and Obstructive Lung Disease Coordinator of this site? Confirm its status | Hanover | Germany | Recruiting |
| Universitaetsklinikum Schleswig-Holstein, Klinik für Kinder- und Jugendmedizin, Airway Research Center North Coordinator of this site? Confirm its status | Lübeck | Germany | Recruiting |
| Klinik für Kinder- und Jugendmedizin, Universitaetsklinikum Giessen und Marburg GmbH, Universities of Giessen and Marburg Lung Center Coordinator of this site? Confirm its status | Marburg | Germany | Recruiting |
| Klinikum der Universitaet Muenchen, Comprehensive Pulmonary Center Munich Coordinator of this site? Confirm its status | Munich | Germany | Recruiting |
Related publications
- Nasal Epithelial Immune Signatures Are Associated With Age-Dependent Asthma Trajectories in Early Life.Allergy · 2026 · PMID 42703035
- Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE.Respir Res · 2026 · PMID 42509549
This page is information, not medical advice. Discuss any trial with your doctor.