NCT02504697Active, not recruiting
DECAMP-2: Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer
Detection of Early Lung Cancer Among Military Personnel Study 2 (DECAMP-2): Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer
Source: ClinicalTrials.gov · Last updated 1 Apr 2026
Brief summary (registry, in English)
The goal of this project is to improve lung cancer screening in high-risk individuals by identifying biomarkers of preclinical disease and disease risk that are measured in minimally invasive and non-invasive biospecimens. Existing biomarkers for lung cancer diagnosis as well as new biomarkers discovered specifically in this clinical setting will be examined. Biomarkers that identify individuals at highest risk for being diagnosed with lung cancer prior to the appearance of concerning symptoms could increase the utility of lung cancer surveillance and the efficiency of lung cancer chemoprevention clinical trials. Achieving these goals would improve the detection and treatment of early stage and incipient lung cancer, while restricting the risk of these procedures to those individuals who currently exhibit the early molecular warning signs of impending disease.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 665 (actual)
- First submitted
- 27 May 2014
- Start date
- 1 Sept 2011
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Boston University
- Diseases
- Lung cancer
- NCT number
- NCT02504697
What you commit to
- Study type: Observational
- Participants enrolled: 665
- From 1 Sept 2011 to the primary completion date, 31 Dec 2027
- 15 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Diagnosis of lung cancer prior to the current assessment (that is, patients are eligible if first lung cancer diagnosis has been recently confirmed by bronchoscopic biopsy and is leading to resection surgery, but not if this is not a first diagnosis);
Other illness
- Contraindications to nasal brushing or fiberoptic bronchoscopy, including: ulcerative nasal disease, hemodynamic instability, severe obstructive airway disease (i.e., disease severity does not allow for bronchoscopic procedures), unstable cardiac or pulmonary disease, as well as other comorbidities leading to inability to protect airway, or altered level of consciousness;
- Allergies to any local anesthetic that may be used to obtain biosamples in the study;
Other
- Weight greater than that allowable by the CT scanner.
Who the study is looking for
- Ages 50 to 79 years;
- Smoking status: Current or former smoker (≥10 cigarettes/day for current smokers, or ≥20 pack years for former smoker who quit 20 years ago or less)
- History of Chronic Obstructive Pulmonary Disease (COPD), emphysema, or at least one first-degree relative with a diagnosis of lung cancer;
- Willing to undergo fiberoptic bronchoscopy;
- Able to tolerate all biospecimen collection as required by protocol;
- Able to comply with standard-of-care follow-up visits, including clinical exams, diagnostic work-ups, and imaging for a maximum of four years or until diagnosis of lung cancer;
- Able to fill out Patient Lung History questionnaire;
- Willing and able to provide a written informed consent.
Age in the registry: 50 years to 79 years · Sex: All · Accepts healthy volunteers
Sites (15)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Walter Reed National Military Medical Center Coordinator of this site? Confirm its status | Bethesda | United States | Unknown status |
| Boston University Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Boston VA Research Institute, Inc Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Health Research Inc. Roswell Park Division Coordinator of this site? Confirm its status | Buffalo | United States | Unknown status |
| Dallas VA Research Corporation Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Denver Research Institute Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Regents of the University of California LA (Los Angeles VA Healthcare System) Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| University of California Los Angeles Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Middle Tennessee Research Institute (Vanderbilt University) Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Trustees of University of Pennsylvania (Philadelphia VA Medical Center) Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Veterans Research Foundation of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Naval Medical Center - Portsmouth Coordinator of this site? Confirm its status | Portsmouth | United States | Unknown status |
| San Antonio Military Medical Center Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Naval Medical Center -San Diego Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.