NCT02532452RecruitingPhase 2
Third Party Viral Specific T-cells (VSTs)
Third Party Viral Specific T-cells (VSTs) for Treatment of Viral Infections in Immunocompromised Patients
Source: ClinicalTrials.gov · Last updated 4 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to demonstrate that viral specific T-cells (a type of white blood cell) can be generated from an unrelated donor and given safely to patients with viral infections.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 1000 (estimated)
- First submitted
- 21 Aug 2015
- Start date
- 2 Sept 2015
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Children's Hospital Medical Center, Cincinnati
- NCT number
- NCT02532452
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 1000
- From 2 Sept 2015 to the primary completion date, 31 Dec 2028
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Uncontrolled relapse of malignancy requiring treatment with chemotherapy
- Biopsy confirmed acute rejection of solid organ transplant OR empiric treatment of suspected but not confirmed acute rejection of solid organ transplant within the last 30 days
Other illness
- Uncontrolled bacterial or fungal infection
Other
- Active acute GVHD grades II-IV
- Infusion of ATG or alemtuzumab within 2 weeks of VST infusion
Who the study is looking for
- Immunocompromised patient with evidence of viral infection or reactivation
- Age \>1 day
- Recipients who have had a stem cell transplant must be at least 21 days after stem cell infusion
- Clinical status must allow tapering of steroids to \< 0.5mg/kg prednisone or other steroid equivalent
- Must be able to receive CTL infusion in Cincinnati
- Informed consent obtained by PI or sub-investigator either in person or by phone
Age in the registry: 2 days to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Akron Children's Hospital Coordinator of this site? Confirm its status | Akron | United States | Recruiting |
| University of Cincinnati Medical Center Coordinator of this site? Confirm its status | Cincinnati | United States | Completed |
| Cincinnati Children's Hospital Medical Center Coordinator of this site? Confirm its status | Cincinnati | United States | Recruiting |
| The Ohio State University Wexner Medical Center - James Cancer Hospital Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.