NCT02553525Enrolling by invitation
Effects of Stimulation Patterns of Deep Brain Stimulation
Source: ClinicalTrials.gov · Last updated 9 Apr 2026
Brief summary (registry, in English)
The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia or multiple sclerosis (MS). These data will guide the design of novel stimulation patterns that may lead to more effective and reliable treatment with DBS. These data will also enable evaluation of current hypotheses on the mechanisms of action of DBS. Improving our understanding of the mechanisms of action of DBS may lead to full development of DBS as a treatment for Parkinson's disease and may lead to future applications of DBS.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 180 (estimated)
- First submitted
- 15 Sept 2015
- Start date
- 2 Jun 2016
- Primary completion date
- Mar 2027
- Lead sponsor
- Duke University
- Diseases
- Parkinson disease, Multiple sclerosis
- NCT number
- NCT02553525
What you commit to
- Study type: Interventional
- Planned participants: 180
- From 2 Jun 2016 to the primary completion date, Mar 2027
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications
Other
- Inability to execute the motor tasks during the study
- Clinically ineffective DBS
Who the study is looking for
- Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) dystonia or Multiple Sclerosis (MS)
- Scheduled to undergo Deep Brain Stimulation (DBS) electrode implant, IPG implant or implanted pulse generator (IPG) replacement surgery
- Neurologically stable
- Able to understand the study and consent form
Age in the registry: 21 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Emory University Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Duke University Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| University of Florida Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.