Preoperative vs Postoperative IMRT for Extremity/Truncal STS

Prior treatment

• Prior radiotherapy to the target site
• Planned chemotherapy for (neo)adjuvant treatment
• Conservative surgery to the target site

Other illness

• Prior malignancy within the previous five years or concurrent malignancy with the exception of adequately treated basal cell carcinoma of the skin or carcinoma in-situ of the cervix.
• Presence of regional nodal disease or unequivocal distant metastases.
• Other major medical illness deemed to preclude safe administration of protocol treatment or required follow-up.

Other

• Benign histology.

• Histologically proven soft tissue sarcoma of the extremity or trunk following review by local reference pathologist.
• Deemed appropriate for preoperative or postoperative radiotherapy and conservative surgery following patient assessment by a radiation oncologist and surgical oncologist.
• Lesion is primary or locally recurrent. Patient may have undergone excisional biopsy with positive margins at a referring hospital and are eligible following discussion among the surgical oncologists and radiation oncologists that IMRT is an acceptable treatment for that case.
• Eastern Cooperative Oncology Group (ECOG) score 0-3
• Patient is aged 18years or older.
• Patient is able to provide informed consent
• Patient is available for treatment and follow-up.