NCT02595255Recruiting
AMH as a Predictor of Infertility Risk in Children With Cancer (CHANCE)
Antimüllerian Hormone as a Predictor of Future Infertility Risk in Prepubertal/Pubertal Cancer Patients
Source: ClinicalTrials.gov · Last updated 12 Aug 2026
Brief summary (registry, in English)
While most of the children spontaneously recover menstruation or experienced normal puberty after chemotherapy, their ovarian reserve may be impaired by treatment inducing future infertility. Fertility preservation is currently proposed for selected prepubertal patients with a high risk of premature ovarian failure after treatment (mostly conditioning regimen for bone marrow transplantation). For patients with low or moderate risks, counselling is very difficult and no fertility preservation procedure is usually proposed for these patients as no marker of the ovarian reserve has been validated in this young population to assess the individual risk. The primary objective of the study is to prevent long-term treatment-related infertility by detecting the young patients who normally progressed to menarche but have a reduced ovarian reserve. These patients may benefit from particular follow-up and fertility preservation procedure.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 275 (estimated)
- First submitted
- 2 Nov 2015
- Start date
- 1 Apr 2014
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Erasme University Hospital
- Diseases
- Childhood cancers
- NCT number
- NCT02595255
What you commit to
- Study type: Observational
- Planned participants: 275
- From 1 Apr 2014 to the primary completion date, 31 Dec 2026
- 8 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- CNS (central nervous system) irradiation, cerebral tumour
- Current or previous ovarian disease/surgery
- Previous known severe chronic disease potentially affecting normal growth or puberty (diseases inducing malnutrition, anorexia, genetic/congenital disorders as Turner, Kallman, BPES(Blepharophimosis, ptosis, and epicanthus inversus syndrome) syndromes, uncontrolled severe diabetes, Cushing Syndrome, auto-immune diseases, cystic fibrosis, severe renal dysfunction)
Other illness
- Familial history of premature ovarian failure (no iatrogenic or surgical origins)
- Genetic/congenital disorders inducing mental retardation
Who the study is looking for
- Patients from 3 to 14 year old included - Belong to one of these 3 groups (modified from Wallace et al, 2005):
- High risk : Conditioning therapy for bone marrow transplantation or pelvic irradiation
- Moderate/Low risk : Pathologies treated with chemotherapy regimen with moderate or low risk of inducing ovarian function insufficiency: AML, osteosarcoma, Ewing sarcoma, neuroblastoma, non-Hodgkin lymphoma, Hodgkin lymphoma, soft tissue sarcoma, ALL, Wilms tumour, retinoblastoma.
- No risk (control group) : patients with chronic benign diseases or malignancies who don't receive any chemotherapy or other gonadotoxic treatment.
Age in the registry: 3 years to 14 years · Sex: Female · Does not accept healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universitair Ziekenhuis Antwerpen Coordinator of this site? Confirm its status | Antwerp | Belgium | Recruiting |
| Hôpital Universitaire Reine Fabiola (HUDERF) Coordinator of this site? Confirm its status | Brussels | Belgium | Recruiting |
| Universitair Ziekenhuis Brussels Coordinator of this site? Confirm its status | Brussels | Belgium | Recruiting |
| Universitair Ziekenhuis Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Recruiting |
| Centre Hospitalier Régional (CHR)-Citadelle Coordinator of this site? Confirm its status | Liège | Belgium | Recruiting |
| Centre Hospitalier Chrétien (CHC)- Clinique de l'espérance Coordinator of this site? Confirm its status | Montegnée | Belgium | Recruiting |
| Centre Oscar Lambret Coordinator of this site? Confirm its status | Lille | France | Recruiting |
| CHRU Lille - Hôpital Jeanne de Flandre Coordinator of this site? Confirm its status | Lille | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.