NCT02610413Recruiting
Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer
Exploratory Next Generation Sequencing to Identify Causative Variants for Bevacizumab-Induced Hypertension From Breast Cancer Study E5103 Germline DNA Samples
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with hypertension receiving bevacizumab for breast cancer. Studying samples of germline DNA in the laboratory from patients with hypertension receiving bevacizumab for breast cancer may help doctors learn about changes that occur in DNA and identify biomarkers related to hypertension.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 354 (estimated)
- First submitted
- 19 Nov 2015
- Start date
- 25 Mar 2014
- Primary completion date
- 1 Jan 2100
- Lead sponsor
- National Cancer Institute (NCI)
- Diseases
- High blood pressure, Childhood cancers
- NCT number
- NCT02610413
What you commit to
- Study type: Observational
- Planned participants: 354
- From 25 Mar 2014 to the primary completion date, 1 Jan 2100
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- European American patients with deoxyribonucleic acid (DNA) available and designated case or control
- Patients who developed grade 3-4 bevacizumab-induced hypertension during their treatment with bevacizumab
- Patients who did not develop hypertension following a full course of treatment with bevacizumab
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Eastern Cooperative Oncology Group Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.