NCT02627183Completed
Circulating BDNF in Patients With Atrial Fibrillation Undergoing Catheter Ablation or Exercise Training
Circulating Brain-derived Neurotrophic Factor (BDNF) in Patients With Atrial Fibrillation Undergoing Catheter Ablation or Exercise Training: A Pilot Study (NEURO-AF)
Source: ClinicalTrials.gov · Last updated 1 May 2026
Brief summary (registry, in English)
The main purpose of this project is to determine the impact of atrial fibrillation interventions (catheter ablation and exercise training) on circulating BDNF concentrations in patients with atrial fibrillation. It also seeks to determine if there is a relation between circulating BDNF concentrations and mental health (depression severity, quality of life and symptoms) among those undergoing interventions for atrial fibrillation catheter ablation or exercise training.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 8 Dec 2015
- Start date
- 16 Feb 2016
- Primary completion date
- 13 Jun 2024
- Lead sponsor
- Ottawa Heart Institute Research Corporation
- Diseases
- Atrial fibrillation
- NCT number
- NCT02627183
What you commit to
- Study type: Observational
- Planned participants: 200
- From 16 Feb 2016 to the primary completion date, 13 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Subject is not either currently enrolled in the OPPORTUNITY trial (NCT02602457) or scheduled to undergo catheter ablation (for the first time) through the electrophysiology clinic at the University of Ottawa Heart Institute for paroxysmal atrial fibrillation.
- Subjects with congestive heart failure with heart failure admission in the past 3 months.
- Subjects with severe dementia.
- Subjects with a history of severe psychiatric illness (e.g., schizoaffective disorder, bipolar disorder, or schizophrenia).
- Subjects with an active infection or inflammatory condition.
Other
- Subjects with a cerebrovascular accident in the past 3 months
- Subjects who are pregnant, lactating or planning to become pregnant during the study period.
- Subject is unable to read or understand English or French.
- Subject is unable to provide informed consent.
Who the study is looking for
- Subjects must be either currently enrolled in the OPPORTUNITY trial (NCT02602457) or have paroxysmal atrial fibrillation and be scheduled to undergo catheter ablation (for the first time) through the electrophysiology clinic at the University of Ottawa Heart Institute.
- Subjects must be willing and able to provide a blood sample.
- Subjects must be willing and able to provide informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Ottawa Heart Institute Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.