NCT02638142Recruiting
Loop Diuretic Therapy in Acutely Decompensated Heart Failure
Continuous Versus Bolus Intermittent Loop Diuretic Infusion in Acutely Decompensated Heart Failure: Evaluation of Renal Function, Congestion Signs, BNP and Outcome
Source: ClinicalTrials.gov · Last updated 8 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF. Previous pilot study design was planned to anticipate a larger multicenter trial able to definitively evaluate the optimal loop diuretic use strategy in patients with ADHF.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 370 (estimated)
- First submitted
- 9 Dec 2015
- Start date
- 1 Dec 2015
- Primary completion date
- 31 Jan 2028
- Lead sponsor
- University of Siena
- Diseases
- Heart failure
- NCT number
- NCT02638142
What you commit to
- Study type: Observational
- Planned participants: 370
- From 1 Dec 2015 to the primary completion date, 31 Jan 2028
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- End-Stage renal disease or renal replacement therapy;
- Recent myocardial infarction (within thirty days of screening);
- Patients affected by sepsis, liver diseases, inflammatory diseases or neoplastic diseases.
Lab values
- Creatinine levels \> 4 mg/dL;
Other
- Patients who receive more than 40 mg of IV furosemide;
- Systolic blood pressure \< 80 mmHg;
Who the study is looking for
- Patients over 18 years;
- Patients with diagnosis of ADHF(dyspnea, orthopnea, peripheral edema or major fatigue and at least two clinical signs including rales, hepatomegaly, pulmonary congestion on chest radiography, jugular vein dilatation, or a third heart sound);
- Blood BNP \> 100 pg/mL;
- ADHF: Acute Decompensated Heart Failure; BNP: B-type Natriuretic Peptide; IV: IntraVenous; LVEF: Left Ventricular Ejection Fraction.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ospedale Madonna della Navicella Coordinator of this site? Confirm its status | Chioggia | Italy | Recruiting |
| Azienda Ospedaliera di Padova Coordinator of this site? Confirm its status | Padova | Italy | Recruiting |
| University of Rome La Sapienza Coordinator of this site? Confirm its status | Roma | Italy | Recruiting |
| Department of Internal Medicine, Cardiovascular Diseases Unit Coordinator of this site? Confirm its status | Siena | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.