NCT02661503CompletedPhase 3
HD21
HD21 for advanced stages - Treatment optimization trial in the first-line treatment of advanced stage Hodgkin lymphoma; comparison of 4-6 cycles of escalated BEACOPP with 4-6 cycles of BrECADD
Source: EU CTIS (euclinicaltrials.eu) · Last updated 19 Nov 2024
Brief summary (registry, in English)
Primary objective of the trial is to demonstrate reduced toxicity of the BrECADD treatment compared to escalated BEACOPP treatment measured by treatment-related morbidity (TRMB). Co-primary objective is to further demonstrate non-inferior efficacy of 6 cycles BrECADD compared to 6 cycles of escalated BEACOPP, each followed by radiotherapy to PET-positive residual lesions, in terms of progression-free survival.
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 1320 (actual)
- First submitted
- 1 Oct 2024
- Start date
- Jul 2016
- Lead sponsor
- University Of Cologne
- Diseases
- Hodgkin lymphoma
- NCT number
- NCT02661503
- EU CT number
- 2024-518022-33-00
- EudraCT number
- 2014-005130-55
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 1320
- 163 sites in 6 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior chemotherapy or radiotherapy (prephase is allowed as outlined in the protocol)
Other illness
- Previous malignancy (exeptions: basalioma, carcinoma in situ of the cervix uteri, completely resected melanoma TNMpT1)
- Current disease which precludes protocol treatment
Lab values
- Composite lymphoma or nodular lymphocyte-predominat Hodgkin lymphoma
Other
- Pregnancy, lactation
- Non-Compliance
Who the study is looking for
- Histologically proven classical Hodgkin lymphoma
- First diagnosis, no previous treatment
- Stage IIB with large mediastinal mass and/or extranodal lesions, stage III or IV
- Randomized main study: 18 to 60 years of age
- Cohort of older patients: 61 to 75 years of age
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (163)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vorarlberger Krankenhaus-Betriebsgesellschaft mbH Coordinator of this site? Confirm its status | Feldkirch | Austria | Completed |
| Medizinische Universitaet Innsbruck Coordinator of this site? Confirm its status | Innsbruck | Austria | Completed |
| Steiermaerkische Krankenanstalten Ges.m.b.H. Coordinator of this site? Confirm its status | Leoben | Austria | Completed |
| Ordensklinikum Linz GmbH Coordinator of this site? Confirm its status | Linz | Austria | Completed |
| Kepler Universitaetsklinikum GmbH Coordinator of this site? Confirm its status | Linz | Austria | Completed |
| SCRI CCCIT Ges.m.b.H. Coordinator of this site? Confirm its status | Salzburg | Austria | Completed |
| Oberoesterreichische Gesundheitsholding GmbH Coordinator of this site? Confirm its status | Steyr | Austria | Completed |
| Hanusch Krankenhaus der Wiener Gebietskrankenkasse Coordinator of this site? Confirm its status | Vienna | Austria | Completed |
| Allgemeines Krankenhaus Der Stadt Wien Universitatskliniken Coordinator of this site? Confirm its status | Vienna | Austria | Completed |
| Gemeinsschaftspraxis Dr. med. Dirk Tummes, Dr. med. Dorothee Guggenberger, Dr. med Andreas Lang Coordinator of this site? Confirm its status | Aachen | Germany | Completed |
| Universitaetsklinikum Aachen AöR Coordinator of this site? Confirm its status | Aachen | Germany | Completed |
| Klinikum Aschaffenburg-Alzenau gGmbH Coordinator of this site? Confirm its status | Aschaffenburg | Germany | Completed |
| Gemeinschaftspraxis - Dr. Slawik/ Dr. Plath Coordinator of this site? Confirm its status | Augsburg | Germany | Completed |
| Universitaetsklinikum Augsburg Coordinator of this site? Confirm its status | Augsburg | Germany | Completed |
| Haematologie-Onkologie im Zentrum MVZ GmbH Coordinator of this site? Confirm its status | Augsburg | Germany | Completed |
| HELIOS Klinikum Bad Saarow GmbH Coordinator of this site? Confirm its status | Bad Saarow | Germany | Completed |
| Sozialstiftung Bamberg Medizinisches Versorgungszentrum Am Bruderwald gGmbH Coordinator of this site? Confirm its status | Bamberg | Germany | Completed |
| Klinikum Bayreuth GmbH Coordinator of this site? Confirm its status | Bayreuth | Germany | Completed |
| Vivantes Netzwerk fuer Gesundheit GmbH Coordinator of this site? Confirm its status | Berlin | Germany | Completed |
| Charite Universitaetsmedizin Berlin KöR Coordinator of this site? Confirm its status | Berlin | Germany | Completed |
| HELIOS Klinikum Berlin Buch GmbH Coordinator of this site? Confirm its status | Berlin | Germany | Completed |
| Onkologische Schwerpunkpraxis Kurfürstendamm Coordinator of this site? Confirm its status | Berlin | Germany | Completed |
| Vivantes MVZ GmbH Coordinator of this site? Confirm its status | Berlin | Germany | Completed |
| Onkologisches Versorgungszentrum Friedrichshain Hämatologie, Onkologie und Palliativmedizin Coordinator of this site? Confirm its status | Berlin | Germany | Completed |
| Onkologische Schwerpunktpraxis Coordinator of this site? Confirm its status | Bielefeld | Germany | Completed |
| Universitaetsklinikum Knappschaftskrankenhaus Bochum GmbH Coordinator of this site? Confirm its status | Bochum | Germany | Completed |
| Universitaetsklinikum Bonn AöR Coordinator of this site? Confirm its status | Bonn | Germany | Completed |
| Johanniter GmbH Coordinator of this site? Confirm its status | Bonn | Germany | Completed |
| Medizinische Versorgungszentren am Städtischen Klinikum Braunschweig Coordinator of this site? Confirm its status | Braunschweig | Germany | Completed |
| Diako Ev. Diakonie-Krankenhaus gGmbH Coordinator of this site? Confirm its status | Bremen | Germany | Completed |
| Gesundheit Nord gGmbH Klinikverbund Bremen Coordinator of this site? Confirm its status | Bremen | Germany | Completed |
| Hamatologische Onkologische Praxis Im Medicum Coordinator of this site? Confirm its status | Bremen | Germany | Completed |
| Staedtisches Klinikum Braunschweig gGmbH Coordinator of this site? Confirm its status | Brunswick | Germany | Completed |
| Klinikum Chemnitz gGmbH Coordinator of this site? Confirm its status | Chemnitz | Germany | Completed |
| University Hospital Cologne AöR Coordinator of this site? Confirm its status | Cologne | Germany | Completed |
| Klinikum Darmstadt GmbH Coordinator of this site? Confirm its status | Darmstadt | Germany | Completed |
| Staedtisches Klinikum Dessau Coordinator of this site? Confirm its status | Dessau-Rosslau | Germany | Completed |
| Kath. St. Paulus GmbH Coordinator of this site? Confirm its status | Dortmund | Germany | Completed |
| Klinikum Dortmund gGmbH Coordinator of this site? Confirm its status | Dortmund | Germany | Completed |
| Gemeinschaftspraxis Haematologie Onkologie Coordinator of this site? Confirm its status | Dresden | Germany | Completed |
| Onkozentrum Dresden Freiberg Meissen Coordinator of this site? Confirm its status | Dresden | Germany | Completed |
| Gemeinschaftspraxis Dr. med. Johannes Mohm, Dr. med. Gabriele Prange-Krex Coordinator of this site? Confirm its status | Dresden | Germany | Completed |
| Technische Universitaet Dresden Coordinator of this site? Confirm its status | Dresden | Germany | Completed |
| Universitaetsklinikum Duesseldorf AöR Coordinator of this site? Confirm its status | Duesseldorf | Germany | Completed |
| Universitaetsklinikum Erlangen AöR Coordinator of this site? Confirm its status | Erlangen | Germany | Completed |
| St.-Antonius-Hospital gGmbH Coordinator of this site? Confirm its status | Eschweiler | Germany | Completed |
| Universitaetsklinikum Essen (AoR) Coordinator of this site? Confirm its status | Essen | Germany | Completed |
| KLINIKEN ESSEN SUED Evangelisches Krankenhaus Essen-Werden gGmbH Coordinator of this site? Confirm its status | Essen | Germany | Completed |
| Klinikum Esslingen GmbH Coordinator of this site? Confirm its status | Esslingen am Neckar | Germany | Completed |
| Malteser Norddeutschland gGmbH Coordinator of this site? Confirm its status | Flensburg | Germany | Completed |
| Krankenhaus Nordwest GmbH Coordinator of this site? Confirm its status | Frankfurt am Main | Germany | Completed |
| Goethe University Frankfurt Coordinator of this site? Confirm its status | Frankfurt Am Main | Germany | Completed |
| Medical Center- University of Freiburg Coordinator of this site? Confirm its status | Freiburg im Breisgau | Germany | Completed |
| Praxis Fuer Interdisziplinaere Onkologie And Haematologie GbR Coordinator of this site? Confirm its status | Freiburg Im Breisgau | Germany | Completed |
| Klinikum Fulda gAG Coordinator of this site? Confirm its status | Fulda | Germany | Completed |
| Justus-Liebig-Universitaet Giessen Coordinator of this site? Confirm its status | Giessen | Germany | Completed |
| Gemeinschaftspraxis Hämatologie-Onkologie Gießen Coordinator of this site? Confirm its status | Gießen | Germany | Completed |
| Wilhelm-Anton-Hospital Goch Coordinator of this site? Confirm its status | Goch | Germany | Completed |
| Universitaetsmedizin Goettingen Coordinator of this site? Confirm its status | Goettingen | Germany | Completed |
| MVZ Onkologische Kooperation Harz GbR Coordinator of this site? Confirm its status | Goslar | Germany | Completed |
| Universitaetsmedizin Greifswald KöR Coordinator of this site? Confirm its status | Greifswald | Germany | Completed |
| Gemeinschaftspraxis Dr Med Regina Moeller Dr Med Tabea Appel Anett Krziwanie Coordinator of this site? Confirm its status | Halle | Germany | Completed |
| MVZ III Onkologie der Evidia MVZ Halle (Saale) Coordinator of this site? Confirm its status | Halle | Germany | Completed |
| University Medical Center Hamburg-Eppendorf Coordinator of this site? Confirm its status | Hamburg | Germany | Completed |
| Asklepios Kliniken Hamburg GmbH Coordinator of this site? Confirm its status | Hamburg | Germany | Completed |
| OncoResearch Lerchenfeld GmbH Coordinator of this site? Confirm its status | Hamburg | Germany | Completed |
| Asklepios Klinik St George Coordinator of this site? Confirm its status | Hamburg | Germany | Completed |
| Gemeinschaftspraxis - Dres. Verpoort, Wierecky und Brandl Coordinator of this site? Confirm its status | Hamburg | Germany | Completed |
| HOPA MVZ GmbH Coordinator of this site? Confirm its status | Hamburg | Germany | Completed |
| Albertinen-Krankenhaus/Albertinen-Haus gGmbH Coordinator of this site? Confirm its status | Hamburg | Germany | Completed |
| Evangelisches Krankenhaus Hamm gGmbH Coordinator of this site? Confirm its status | Hamm | Germany | Completed |
| Klinikum Hanau GmbH Coordinator of this site? Confirm its status | Hanau | Germany | Completed |
| Medizinische Hochschule Hannover Coordinator of this site? Confirm its status | Hanover | Germany | Completed |
| Klinikum Region Hannover GmbH Coordinator of this site? Confirm its status | Hanover | Germany | Completed |
| DIAKOVERE Krankenhaus gGmbH Coordinator of this site? Confirm its status | Hanover | Germany | Completed |
| Universitaetsklinikum Heidelberg AöR Coordinator of this site? Confirm its status | Heidelberg | Germany | Completed |
| Onkologische Schwerpunktpraxis Heidelberg Coordinator of this site? Confirm its status | Heidelberg | Germany | Completed |
| SLK-Kliniken Heilbronn GmbH Coordinator of this site? Confirm its status | Heilbronn | Germany | Completed |
| St. Bernward Krankenhaus GmbH Coordinator of this site? Confirm its status | Hildesheim | Germany | Completed |
| Universitaet Des Saarlandes Coordinator of this site? Confirm its status | Homburg | Germany | Completed |
| Klinikum Idar-Oberstein GmbH Coordinator of this site? Confirm its status | Idar-Oberstein | Germany | Completed |
| Universitaetsklinikum Jena KöR Coordinator of this site? Confirm its status | Jena | Germany | Completed |
| Westpfalz-Klinikum GmbH Coordinator of this site? Confirm its status | Kaiserslautern | Germany | Completed |
| Vincentius-Diakonissen-Kliniken gAG Coordinator of this site? Confirm its status | Karlsruhe | Germany | Completed |
| Staedtisches Klinikum Karlsruhe gGmbH Coordinator of this site? Confirm its status | Karlsruhe | Germany | Completed |
| Klinikverbund Allgaeu gGmbH Coordinator of this site? Confirm its status | Kempten (Allgau) | Germany | Completed |
| Universitaetsklinikum Schleswig-Holstein AöR Coordinator of this site? Confirm its status | Kiel | Germany | Completed |
| Institut fuer Versorgungsforschung in der Onkologie GbR Coordinator of this site? Confirm its status | Koblenz | Germany | Completed |
| Gemeinschaftsklinikum Mittelrhein gGmbH Coordinator of this site? Confirm its status | Koblenz | Germany | Completed |
| HELIOS Klinikum Krefeld GmbH Coordinator of this site? Confirm its status | Krefeld | Germany | Completed |
| Dr. Vehling-Kaiser MVZ GmbH Coordinator of this site? Confirm its status | Landshut | Germany | Completed |
| Gemeinschaftspraxis für Hämatologie und Onkologie Lebach Coordinator of this site? Confirm its status | Lebach | Germany | Completed |
| Universitaet Leipzig Coordinator of this site? Confirm its status | Leipzig | Germany | Completed |
| Onkopraxis Probstheida Coordinator of this site? Confirm its status | Leipzig | Germany | Completed |
| Klinikum Lippe GmbH Coordinator of this site? Confirm its status | Lemgo | Germany | Completed |
| Krankenhausgesellschaft St. Vincenz mbH Coordinator of this site? Confirm its status | Limburg | Germany | Completed |
| Klinikum der Stadt Ludwigshafen am Rhein gGmbH Coordinator of this site? Confirm its status | Ludwigshafen Am Rhein | Germany | Completed |
| Universitaetsklinikum Schleswig-Holstein AöR Coordinator of this site? Confirm its status | Luebeck | Germany | Completed |
| Schwerpunktpraxis für Hämatologie und Onkologie Coordinator of this site? Confirm its status | Magdeburg | Germany | Completed |
| Universitaetsklinikum Magdeburg AöR Coordinator of this site? Confirm its status | Magdeburg | Germany | Completed |
| Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR Coordinator of this site? Confirm its status | Mainz | Germany | Completed |
| Mannheimer Onkologiepraxis - Dr. Plöger/ Dr. Schuster/ Dr. Brust Coordinator of this site? Confirm its status | Mannheim | Germany | Completed |
| Philipps-Universitaet Marburg Coordinator of this site? Confirm its status | Marburg | Germany | Completed |
| Internistisches Facharztzentrum - Praxis für Hämatologie und Onkologie Coordinator of this site? Confirm its status | Memmingen | Germany | Completed |
| Johannes Wesling Klinikum Minden Coordinator of this site? Confirm its status | Minden | Germany | Completed |
| Kliniken Maria Hilf GmbH Moenchengladbach Coordinator of this site? Confirm its status | Moenchengladbach | Germany | Completed |
| Universitaetsklinikum Muenster AöR Coordinator of this site? Confirm its status | Muenster | Germany | Completed |
| MVZ für Hämatologie und Onkologie der MVZ-Medizinisches Versorgungszentrum Mülheim GmbH Coordinator of this site? Confirm its status | Mülheim an der Ruhr | Germany | Completed |
| Klinikum der Universitaet Muenchen AöR Coordinator of this site? Confirm its status | Munich | Germany | Completed |
| Hospital Munich Schwabing Coordinator of this site? Confirm its status | Munich | Germany | Completed |
| Haematologie und Onkologie Muenchen-Pasing MVZ GmbH Coordinator of this site? Confirm its status | Munich | Germany | Completed |
| Klinikum rechts der Isar der TU Muenchen AöR Coordinator of this site? Confirm its status | Munich | Germany | Completed |
| Gemeinschaftspraxis für Hämatologie und Onkologie Coordinator of this site? Confirm its status | Münster | Germany | Completed |
| Kliniken Ostalb gemeinnuetzige kommunale Anstalt des oeffentlichen Rechts Coordinator of this site? Confirm its status | Mutlangen | Germany | Completed |
| FEK Friedrich-Ebert-Krankenhaus Neumuenster GmbH Coordinator of this site? Confirm its status | Neumuenster | Germany | Completed |
| Rheinland Klinikum Neuss GmbH Coordinator of this site? Confirm its status | Neuss | Germany | Completed |
| Klinikum Nuernberg Coordinator of this site? Confirm its status | Nuremberg | Germany | Completed |
| Internistische Gemeinschaftspraxis - Dr. Zimber/ Dr. Brendel/ Dr. Hoesl/ Dr. Maintz Coordinator of this site? Confirm its status | Nürnberg | Germany | Completed |
| Ortenau Klinikum Coordinator of this site? Confirm its status | Offenburg | Germany | Completed |
| Pius Hospital Oldenburg Coordinator of this site? Confirm its status | Oldenburg | Germany | Completed |
| Klinikum Oldenburg Aor Coordinator of this site? Confirm its status | Oldenburg | Germany | Completed |
| Medizinisches Versorgungszentrum des Bruederkrankenhauses St. Josef Paderborn gGmbH Coordinator of this site? Confirm its status | Paderborn | Germany | Completed |
| Klinikum Ernst von Bergmann gGmbH Coordinator of this site? Confirm its status | Potsdam | Germany | Completed |
| Studienzentrum Onkologie Ravensburg GmbH Coordinator of this site? Confirm its status | Ravensburg | Germany | Completed |
| Universitaetsklinikum Regensburg AöR Coordinator of this site? Confirm its status | Regensburg | Germany | Completed |
| Rostock University Medical Center Coordinator of this site? Confirm its status | Rostock | Germany | Completed |
| Praxis für Hämatologie und Onkologie Coordinator of this site? Confirm its status | Saarbrücken | Germany | Completed |
| Diakonie-Klinikum Schwaebisch Hall gGmbH Coordinator of this site? Confirm its status | Schwaebisch Hall | Germany | Completed |
| Marien Gesellschaft Siegen gGmbH Coordinator of this site? Confirm its status | Siegen | Germany | Completed |
| Klinikum Sindelfingen-Böblingen gGmbH Coordinator of this site? Confirm its status | Sindelfingen | Germany | Completed |
| Klinik Dr. Hancken GmbH Coordinator of this site? Confirm its status | Stade | Germany | Completed |
| Klinikum Der Landeshauptstadt Stuttgart gKAöR Coordinator of this site? Confirm its status | Stuttgart | Germany | Completed |
| Robert Bosch Krankenhaus GmbH Coordinator of this site? Confirm its status | Stuttgart | Germany | Completed |
| Vinzenz Von Paul Kliniken gGmbH Coordinator of this site? Confirm its status | Stuttgart | Germany | Completed |
| Diakonie-Klinikum Stuttgart Diakonissenkrankenhaus Und Paulinenhilfe gGmbH Coordinator of this site? Confirm its status | Stuttgart | Germany | Completed |
| Kliniken Suedostbayern AG Coordinator of this site? Confirm its status | Traunstein | Germany | Completed |
| Barmherzige Brueder Trier gGmbH Coordinator of this site? Confirm its status | Trier | Germany | Completed |
| Klinikum Mutterhaus der Borromaeerinnen gGmbH Coordinator of this site? Confirm its status | Trier | Germany | Completed |
| Hämatologisch-Onkologische Schwerpunktpraxis - Dr. Forstbauer Coordinator of this site? Confirm its status | Troisdorf | Germany | Completed |
| Universitaetsklinikum Tuebingen AöR Coordinator of this site? Confirm its status | Tuebingen | Germany | Completed |
| Universitaetsklinikum Ulm AoR Coordinator of this site? Confirm its status | Ulm | Germany | Completed |
| Schwarzwald-Baar Klinikum Villingen-Schwenningen GmbH Coordinator of this site? Confirm its status | Villingen-Schwenningen | Germany | Completed |
| Lahn-Dill-Kliniken GmbH Coordinator of this site? Confirm its status | Wetzlar | Germany | Completed |
| Helios Dr. Horst Schmidt Kliniken Wiesbaden GmbH Coordinator of this site? Confirm its status | Wiesbaden | Germany | Completed |
| Onkologisches Zentrum Wolfsburg-Helmstedt MVZ GmbH Coordinator of this site? Confirm its status | Wolfsburg | Germany | Completed |
| Internistische Gemeinschaftspraxis - Dr. Burkhard / Dr. Reimann / Dr. Lorentz Coordinator of this site? Confirm its status | Worms | Germany | Completed |
| Universitaetsklinikum Wuerzburg AöR Coordinator of this site? Confirm its status | Wuerzburg | Germany | Completed |
| Helios Universitaetsklinikum Wuppertal Coordinator of this site? Confirm its status | Wuppertal | Germany | Completed |
| Region Midtjylland Coordinator of this site? Confirm its status | Aarhus N | Denmark | Completed |
| Odense University Hospital Coordinator of this site? Confirm its status | Odense C | Denmark | Completed |
| Meander Medisch Centrum Coordinator of this site? Confirm its status | Amersfoort | Netherlands | Completed |
| Stichting OLVG Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Completed |
| Amsterdam UMC Stichting Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Completed |
| Admiraal De Ruyter Ziekenhuis B.V. Coordinator of this site? Confirm its status | Goes | Netherlands | Completed |
| Leids Universitair Medisch Centrum (LUMC) Coordinator of this site? Confirm its status | Leiden | Netherlands | Completed |
| Jeroen Bosch Ziekenhuis Stichting Coordinator of this site? Confirm its status | 'S-Hertogenbosch | Netherlands | Completed |
| Helse Bergen HF Coordinator of this site? Confirm its status | Bergen | Norway | Completed |
| Oslo University Hospital HF Coordinator of this site? Confirm its status | Oslo | Norway | Completed |
| St. Olavs hospital HF Coordinator of this site? Confirm its status | Trondheim | Norway | Completed |
| Sahlgrenska University Hospital-Vaestra Goetalandsregionen Coordinator of this site? Confirm its status | Goteborg | Sweden | Completed |
| Region Oestergoetland Coordinator of this site? Confirm its status | Linkoping | Sweden | Completed |
| Region Vaesterbotten Coordinator of this site? Confirm its status | Umea | Sweden | Completed |
| Uppsala University Hospital Coordinator of this site? Confirm its status | Uppsala | Sweden | Completed |
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This page is information, not medical advice. Discuss any trial with your doctor.