NCT02664831Recruiting
Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
Immunoinflammatory and Metabolic Responses in Post Cardiac Arrest Syndrome (PCAS)
Source: ClinicalTrials.gov · Last updated 18 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 22 Jan 2016
- Start date
- Jan 2016
- Primary completion date
- Jan 2027
- Lead sponsor
- MaineHealth
- Diseases
- Obesity
- NCT number
- NCT02664831
What you commit to
- Study type: Observational
- Planned participants: 400
- From Jan 2016 to the primary completion date, Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion
Other
- Moribund / actively dying at the time of evaluation
- Informed consent cannot be obtained within 24 hours of resuscitation
Who the study is looking for
- Aged 18 years or older
- Admitted to the intensive care unit after cardiac arrest episode
- Unresponsive after resuscitation
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Maine Medical Center Coordinator of this site? Confirm its status | Portland | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.