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NCT02664831Recruiting

Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

Immunoinflammatory and Metabolic Responses in Post Cardiac Arrest Syndrome (PCAS)

Source: ClinicalTrials.gov · Last updated 18 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open

Brief summary (registry, in English)

This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.

Status (registry)
Recruiting
Study type
Observational
Enrollment
400 (estimated)
First submitted
22 Jan 2016
Start date
Jan 2016
Primary completion date
Jan 2027
Lead sponsor
MaineHealth
Diseases
Obesity
NCT number
NCT02664831

What you commit to

  • Study type: Observational
  • Planned participants: 400
  • From Jan 2016 to the primary completion date, Jan 2027
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Lab values

  • Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion

Other

  • Moribund / actively dying at the time of evaluation
  • Informed consent cannot be obtained within 24 hours of resuscitation

Who the study is looking for

  • Aged 18 years or older
  • Admitted to the intensive care unit after cardiac arrest episode
  • Unresponsive after resuscitation

Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Maine Medical Center
Coordinator of this site? Confirm its status
PortlandUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.