NCT02710370Active, not recruiting
Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans
Source: ClinicalTrials.gov · Last updated 11 Jun 2026
Brief summary (registry, in English)
The purpose of this research study is to determine how gastric bypass surgery effects metabolism in obesity and Type 2 Diabetes. One mechanism that has been investigated in animal models is change to the biology of the small intestine (Roux limb) and how glucose and other fuels are metabolized (or how the body digests and uses sugar and other fuels). This study will evaluate the role of the intestine in the beneficial metabolic effects of gastric bypass surgery. It specifically will examine whether the intestine increases its metabolism and its activity, and whether this results in an increase in fuel utilization. Thirty two (32) subjects will be recruited (18 with and 14 without Type 2 Diabetes). At the time of gastric bypass surgery, a small piece of intestine that is usually discarded will be collected. At three time points over the first year after surgery, intestinal samples will be obtained by endoscopy or insertion of a lighted flexible tube through the mouth. Blood samples will be taken at all time points, as well. All samples will undergo comprehensive metabolic analyses. Comparisons will be made between the two groups to understand the metabolic changes over time and if there are differences between the two groups.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 46 (actual)
- First submitted
- 5 Feb 2016
- Start date
- 1 Feb 2016
- Primary completion date
- 31 Aug 2028
- Lead sponsor
- University of Pittsburgh
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT02710370
What you commit to
- Study type: Observational
- Participants enrolled: 46
- From 1 Feb 2016 to the primary completion date, 31 Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior bariatric or foregut surgery
- Drug and/or alcohol addiction
Other illness
- Documented history of Type 1 Diabetes
- Portal hypertension and/or cirrhosis
Other
- Poor overall general health
- Impaired mental status
- Currently smoking
- Pregnant or plans to become pregnant
Who the study is looking for
- Patients who elect to undergo gastric bypass surgery
- Standard bariatric surgery criteria (A BMI 35 to 40 kg/m2, with an obesity comorbid condition, OR BMI 40 kg/m2 or \>).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Magee-Womens Hospital of UPMC Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.