NCT02726711Active, not recruitingPhase 1
Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic
Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic Aim 1 of Rare Diseases Clinical Research Network (RDCRN) Project 2
Source: ClinicalTrials.gov · Last updated 13 Mar 2026
Brief summary (registry, in English)
The purpose of this study is to learn more about the regulation of the veins of the abdomen by the autonomic (involuntary) nervous system, and how this may affect high blood pressure. Normally, the autonomic nervous system controls how much blood flows in the veins. In people with high blood pressure, however, the autonomic nervous system is changed. This change may affect the way blood flows in the veins of the abdomen which may play a role in their high blood pressure. About 32 participants will be screened for the study. The investigators estimate 16 will be eligible to participate in all of the study days.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 2 (actual)
- First submitted
- 28 Jan 2016
- Start date
- Apr 2016
- Primary completion date
- Dec 2026
- Lead sponsor
- Vanderbilt University
- Diseases
- High blood pressure
- NCT number
- NCT02726711
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 2
- From Apr 2016 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Systemic illnesses known to produce autonomic neuropathy, including but not limited to diabetes mellitus, amyloidosis, monoclonal gammopathies, and autoimmune neuropathies
- History of known aortic aneurysms, thoracic, abdominal or pelvic surgery in the past 6 months
Lab values
- Clinically unstable coronary artery disease or major cardiovascular or neurological event in the past 6 months, and other factors which in the investigator's opinion would prevent the subject from completing the protocol including clinically significant abnormalities in clinical, mental or laboratory testing.
Other
- Pregnancy.
- Symptomatic abdominal or inguinal hernias
- Severe gastroesophageal reflux
- Recent fractures or fissures of ribs, thoracic or lumbar spine
- Medical devices implanted on the abdominal wall or abdomen that would interfere with the abdominal compression
- Intolerance to any increase in intra-abdominal pressure
Who the study is looking for
- Male and female subjects, age 40-80 years, with possible or probable Multiple System Atrophy, as defined by Consensus Criteria.
- Neurogenic orthostatic hypotension defined as a ≥30-mmHg decrease in systolic blood pressure within 3 minutes of standing associated with impaired autonomic reflexes determined by autonomic testing in the absence of other identifiable causes.
- Supine hypertension, defined as systolic blood pressure ≥150 mmHg measured on two separate occasions.
- Subjects able and willing to provide informed consent.
Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.