Imaging SV2A in Mood Disorders

Prior treatment

• History of prior radiation exposure for research purposes within the past year such that participation in this study would place them over FDA limits for annual radiation exposure.
• Previous or anticipated radiation exposure at work within one year of the proposed research PET scans that precludes study participation.
• Arterial line exclusion: History of a bleeding disorder or currently taking anticoagulants (such as Coumadin, Heparin, Pradaxa, Xarelto).

Other illness

• History of significant medical illness that would contraindicate study participation based on above criteria and PI/MD history review.
• Lifetime history of neurologic abnormality including seizure disorder, cerebrovascular or neoplastic lesion, neurodegenerative disorder, or significant head trauma resulting in post-traumatic amnesia \>24 hours.
• Met DSM-5 criteria for mild substance use disorder (except nicotine and marijuana) within the past 6 months or met DSM-5 criteria for moderate to severe substance use disorder within the past year.
• Contraindications to PET (e.g., past or current diagnosis of cancer, poor venous access for placement of venous lines).

Lab values

• Hematocrit levels below 35 mg/dl, and/or hemoglobin levels below 10 mg/dl.

Other

• Full scale IQ lower than 70.
• Contraindication to MRI scanning including claustrophobia and presence of a ferromagnetic object, including orthodontic braces. All participants will be screened for metal objects by the same methods used for routine clinical MRI scanning.
• Pregnancy or breast-feeding.
• Claustrophobia.
• Current psychosis, active suicidal or homicidal ideation.
• Positive urine toxicology screen (except for marijuana).
• Blood pressure \>130/80 (for Aim 2, ketamine challenge); blood pressure \>140/90 (non-ketamine groups).
• Arterial line exclusion: Blood donation within eight weeks of the start of the study.
• Current diagnosis of MDD or PTSD with psychotic features.
• Weight under 110 lbs for subjects who will participate in portions of this study for which the blood draw is at or above a typical blood donation.

• General inclusion criteria:
  • Subjects will be 18-70 years old,
  • English speaking,
  • No other DSM-5 diagnosis present, besides required as below.
• Meet DSM-5 diagnostic criteria for Major Depressive Disorder, and for a current depressive episode.
• Treatment or non-treatment seeking who understand that this study is for research purposes only.
• 1\. No current, or history of any DSM-5 diagnosis.
• 1\. Current Post Traumatic Stress Disorder.
• 1\. Meet DSM-5 diagnostic criteria for bipolar disorder.
• Meet DSM-5 diagnostic criteria for Major Depressive Disorder, and for a current depressive episode, as assessed by structured interview for DSM-5 diagnosis (SCID).
• Undergoing ketamine treatment.