NCT02848885Completed
The Effects of tDCS on Illness Awareness in Schizophrenia
The Clinical and Functional Imaging Effects of Transcranial Direct Current Stimulation (tDCS) on Illness Awareness in Schizophrenia
Source: ClinicalTrials.gov · Last updated 6 Jun 2025
Brief summary (registry, in English)
This is a novel study that seeks to explore the clinical and functional imaging effects of transcranial direct current stimulation (tDCS) on illness awareness or anosognosia in schizophrenia, arguably the most treatment-resistant manifestation of the disorder.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 32 (actual)
- First submitted
- 15 Jul 2016
- Start date
- Aug 2016
- Primary completion date
- May 2025
- Lead sponsor
- Centre for Addiction and Mental Health
- Diseases
- Schizophrenia
- NCT number
- NCT02848885
What you commit to
- Study type: Interventional
- Participants enrolled: 32
- From Aug 2016 to the primary completion date, May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Serious unstable medical illness or any concomitant major medical or neurological illness, including a history of seizures or a first degree relative with a history of a seizure disorder
- DSM-IV substance dependence (except caffeine and nicotine) within one month prior to entering the study
- Positive urine drug screen for drugs of abuse
- Currently taking antiepileptics
- Any contraindications to MRI (eg., metal implants that would preclude an MRI, claustrophobia)
Other illness
- Formal thought disorder rating of over 2 on the (Scale for Assessment of Positive Symptoms) SAPS.
- Mild lack of insight to good illness awareness (\<3 on PANSS G12 Insight and Judgment item).
Other
- Acute suicidal and/or homicidal ideation
- Pregnant women
- Score \< 32 on the Wide Range Achievement Test-III (WRAT III)
Who the study is looking for
- Male or female inpatients or outpatients ≥ 18 years of age
- Having a DSM-IV diagnosis of schizophrenia or schizoaffective disorder
- Voluntary and capable of consenting to participation in the research study
- Fluent in English
- Moderate-to-severe lack of illness awareness (≥3 on PANSS G12 Insight and Judgment item)
- On a stable dose of antipsychotic and other concomitant medications, and unlikely to undergo changes in dose during the study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre for Addiction and Mental Health Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.