NCT02863172Recruiting
Molecular Basis for Variations in Hereditary Colorectal Cancer Syndromes
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
Objectives: 1. To examine the variations in clinical features, survival outcomes, family history, and health behavior among proband patients who are known or suspected to have a hereditary colorectal cancer syndrome 2. To compare the clinical features, survival outcomes, and health behavior of the proband vs. his/her family members who may or may not be affected by the hereditary colorectal cancer syndrome 3. To explore for correlations between germline genetic variations in both the probands and family members with observed variations in the overall disease phenotype across probands and kindreds, within a given syndrome. Disease phenotype is defined to include: (1) clinicopathologic features including patient demographics and oncologic outcomes; (2) clinical manifestations of disease including the timing, spectrum and severity of CRC and extracolonic cancers. Genetic variations may include the specific codon mutated, the type of mutation and sequence alteration (e.g. nonsense, missense etc), chromosomal/gene copy number changes, and gene polymorphisms. 4. To explore for correlations between germline genetic variations in both the probands and family members with observed variations in somatic CRC tumor biology, including tumor pathology and other tumor molecular markers
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 2000 (estimated)
- First submitted
- 8 Aug 2016
- Start date
- 22 May 2012
- Primary completion date
- 30 May 2027
- Lead sponsor
- M.D. Anderson Cancer Center
- Diseases
- Colorectal cancer
- NCT number
- NCT02863172
What you commit to
- Study type: Observational
- Planned participants: 2000
- From 22 May 2012 to the primary completion date, 30 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- N/A
Who the study is looking for
- Probands who meet the following criteria will be eligible:
- Patient must have or is suspected to have a hereditary CRC syndrome
- Patient must be at least 18 years of age at the time of study registration.
- Patient must have sufficient command of the English language and mental capacity to provide consent
- Family members who meet the following criteria will be eligible:
- First- or second-degree relative of a registered MDACC patient who has met eligibility criteria for a Proband as defined above.
- Family member must be at least 18 years of age at the time of study registration.
- Family member must have sufficient command of the English language and mental capacity to provide consent
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Texas - MD Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.